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The journal of nutrition, health & aging

Erschienen in:

13.10.2018

Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults

verfasst von: S. ter Borg, Y. C. Luiking, A. van Helvoort, Y. Boirie, J. M. G. A. Schols, C. P. G. M. de Groot

Erschienen in: The journal of nutrition, health & aging | Ausgabe 1/2019

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Abstract

Background

Sarcopenia, the age-related decrease in muscle mass and function can result in adverse health outcomes and subsequent loss of independence. Inadequate nutrition is an important contributor to the aetiology of sarcopenia, and dietary strategies are studied to prevent or delay this geriatric syndrome.

Objective

The present study investigated whether there is an association between biochemical nutrient status markers, muscle parameters and sarcopenia in community-dwelling older adults.

Design

Data from the cross-sectional Maastricht Sarcopenia study (MaSS) were used, in which skeletal muscle index (SMI), 4 meter gait speed, 5 times chair stand and handgrip strength were assessed among older adults (n=227). Sarcopenia was defined following the algorithm of the European Working Group on Sarcopenia in Older People. Fasted blood samples were analyses on amino acids levels, RBC phospholipid profile, 25-hydroxyvitamin D (25(OH)D), α-tocopherol, magnesium and homocysteine were determined in fasted blood levels. Generalized linear modelling and logistic regression were used for data analysis.

Results

Lower blood levels of essential amino acids (EAA), total branched-chain amino acids (BCAA) and leucine were associated with lower SMI (P<0.001), strength (P<0.001) and longer time to complete the chair stand (P<0.05), whereas no association was found for total amino acids (TAA). Lower levels of eicosapentaenoic acid (EPA), 25(OH)D and homocysteine were associated with lower muscle parameter values (P<0.05). No significant associations were found for SFA, MUFA, PUFA, n-3 and n-6 fatty acids, docosahexaenoic acid (DHA), α-tocopherol-cholesterol ratio and magnesium. Sarcopenia was more frequent among those with lower levels of leucine, BCAA, EAA, EPA, 25(OH)D and higher levels of homocysteine (P<0.05). Age and BMI were identified as relevant covariates. A robust association was only found for lower gait speed and lower 25(OH)D levels.

Conclusion

Compromised muscle parameters are associated with low blood values of specific amino acids, fatty acids, vitamin D and high homocysteine.

Koopman R, van Loon LJ. Aging, exercise, and muscle protein metabolism. Journal of applied physiology 2009;106: 2040–2048CrossRefPubMed

Short KR, Nair KS. Mechanisms of sarcopenia of aging. Journal of endocrinological investigation 1999;22: 95–105PubMed

Lindle RS, Metter EJ, Lynch NA et al. Age and gender comparisons of muscle strength in 654 women and men aged 20–93 yr. Journal of applied physiology 1997;83: 1581–1587CrossRefPubMed

Landi F, Calvani R, Cesari M et al. Sarcopenia: an overview on current definitions, diagnosis and treatment. Curr Protein Pept Sci, 2017

United Nations. Department of Economic and Social Affairs. Population Division Worlds Population Ageing: 1950–2050. https://doi.org/www.un.org/esa/population/publications/worldageing19502050/, accessed 16–07–2017.

Cruz–Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age and ageing 2010;39: 412–423CrossRefPubMedPubMedCentral

Morley JE, Argiles JM, Evans WJ et al. Nutritional recommendations for the management of sarcopenia. Journal of the American Medical Directors Association 2010;11: 391–396CrossRefPubMedPubMedCentral

Bauer J, Biolo G, Cederholm T et al. Evidence–based recommendations for optimal dietary protein intake in older people: a position paper from the PROT–AGE Study Group. Journal of the American Medical Directors Association 2013;14: 542–559CrossRefPubMed

Verlaan S, Aspray TJ, Bauer JM et al. Nutritional status, body composition, and quality of life in community–dwelling sarcopenic and non–sarcopenic older adults: A case–control study. Clin Nutr 2017;36: 267–274CrossRefPubMed

10.

Ten Borg S, de Groot LC, Mijnarends DM et al. Differences in Nutrient Intake and Biochemical Nutrient Status Between Sarcopenic and Nonsarcopenic Older Adults–Results From the Maastricht Sarcopenia Study. Journal of the American Medical Directors Association 2016;17: 393–401

11.

Houston DK, Nicklas BJ, Ding J et al. Dietary protein intake is associated with lean mass change in older, community–dwelling adults: the Health, Aging, and Body Composition (Health ABC) Study. Am J Clin Nutr 2008;87: 150–155CrossRefPubMed

12.

Houston DK, Tooze JA, Garcia K et al. Protein Intake and Mobility Limitation in Community–Dwelling Older Adults: the Health ABC Study. J Am Geriatr Soc 2017;65: 1705–1711CrossRefPubMedPubMedCentral

13.

McDonald CK, Ankarfeldt MZ, Capra S et al. Lean body mass change over 6 years is associated with dietary leucine intake in an older Danish population. The British journal of nutrition 2016;115: 1556–1562CrossRefPubMed

14.

Mithal A, Bonjour JP, Boonen S et al. Impact of nutrition on muscle mass, strength, and performance in older adults. Osteoporosis international: a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 2013;24: 1555–1566CrossRef

15.

Robinson S, Cooper C, Aihie Sayer A. Nutrition and sarcopenia: a review of the evidence and implications for preventive strategies. Journal of aging research 2012;2012: 510801CrossRefPubMedPubMedCentral

16.

Sohl E, van Schoor NM, de Jongh RT et al. Vitamin D status is associated with functional limitations and functional decline in older individuals. The Journal of clinical endocrinology and metabolism 2013;98: E1483–1490CrossRefPubMed

17.

Frison E, Boirie Y, Peuchant E et al. Plasma fatty acid biomarkers are associated with gait speed in community–dwelling older adults: The Three–City–Bordeaux study. Clin Nutr 2017;36: 416–422CrossRefPubMed

18.

Boirie Y. Fighting sarcopenia in older frail subjects: protein fuel for strength, exercise for mass. Journal of the American Medical Directors Association 2013;14: 140–143CrossRefPubMed

19.

Lips P. Vitamin D deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocrine reviews 2001;22: 477–501CrossRefPubMed

20.

Brouwer–Brolsma EM, Vaes AM, van de Zwaluw NL et al. Relative importance of summer sun exposure, vitamin D intake, and genes to vitamin D status in Dutch older adults: The B–PROOF study. The Journal of steroid biochemistry and molecular biology 2016;164: 168–176

21.

Mijnarends DM, Schols JM, Meijers JM et al. Instruments to assess sarcopenia and physical frailty in older people living in a community (care) setting: similarities and discrepancies. Journal of the American Medical Directors Association 2015;16: 301–308CrossRefPubMed

22.

Janssen I, Heymsfield SB, Baumgartner RN et al. Estimation of skeletal muscle mass by bioelectrical impedance analysis. Journal of applied physiology 2000;89: 465–471CrossRefPubMed

23.

Janssen I, Baumgartner RN, Ross R et al. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. American journal of epidemiology 2004;159: 413–421CrossRefPubMed

24.

Lauretani F, Russo CR, Bandinelli S et al. Age–associated changes in skeletal muscles and their effect on mobility: an operational diagnosis of sarcopenia. Journal of applied physiology 2003;95: 1851–1860CrossRefPubMed

25.

Guralnik JM, Simonsick EM, Ferrucci L et al. A short physical performance battery assessing lower extremity function: association with self–reported disability and prediction of mortality and nursing home admission. Journal of gerontology 1994;49: M85–94

26.

Terrlink T, van Leeuwen PA, Houdijk A. Plasma amino acids determined by liquid chromatography within 17 minutes. Clin Chem 1994;40: 245–249PubMed

27.

Olia Araghi S, van Dijk SC, Ham AC et al. BMI and Body Fat Mass Is Inversely Associated with Vitamin D Levels in Older Individuals. The journal of nutrition, health & aging 2015;19: 980–985CrossRef

28.

Sohl E, de Jongh RT, Swart KM et al. The association between vitamin D status and parameters for bone density and quality is modified by body mass index. Calcified tissue international 2015;96: 113–122PubMed

29.

Elin RJ. Magnesium metabolism in health and disease. Disease–a–month: DM 1988;34: 161–218CrossRef

30.

Katsanos CS, Kobayashi H, Sheffield–Moore M et al. A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab 2006;291: E381–387CrossRefPubMed

31.

World Health Organization. Food and Agriculture Organization of the United Nations. United Nations University, 2007. Protein and amino acid requirements in human nutrition. Report of a joint FAO/WHO/UNU expert consultation (WHO Technical Report Series 935). World Health Organization.

32.

Paddon–Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 2009;12: 86–90CrossRefPubMedPubMedCentral

33.

Schmidt JA, Rinaldi S, Scalbert A et al. Plasma concentrations and intakes of amino acids in male meat–eaters, fish–eaters, vegetarians and vegans: a cross–sectional analysis in the EPIC–Oxford cohort. European journal of clinical nutrition 2016;70: 306–312CrossRefPubMed

34.

Newgard CB, An J, Bain JR et al. A branched–chain amino acid–related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 2009;9: 311–326CrossRefPubMedPubMedCentral

35.

Shah SH, Svetkey LP, Newgard CB. Branching out for detection of type 2 diabetes. Cell Metab 2011;13: 491–492CrossRefPubMed

36.

Darmann and Cynober. Chapter 3: Approaches to study amino acid metabolism: from quantitative assays to flux assessment using stable isotopes. In: [Luc A Cynober, (ed)]] Metabolic and therapeutic aspects of amino acids in clinical nutrition, 2nd edition ed. CRC Press LLC, Washington DC, 2004

37.

Abbatecola AM, Cherubini A, Guralnik JM et al. Plasma polyunsaturated fatty acids and age–related physical performance decline. Rejuvenation Res 2009;12: 25–32CrossRefPubMedPubMedCentral

38.

Ross AC, Manson JE, Abrams SA et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism 2011;96: 53–58CrossRefPubMed

39.

Wicherts IS, van Schoor NM, Boeke AJ et al. Vitamin D status predicts physical performance and its decline in older persons. The Journal of clinical endocrinology and metabolism 2007;92: 2058–2065PubMed

40.

Tieland M, Brouwer E, Nienaber–Rousseau C et al. Compromised vitamin D status in frail elderly people is associated with reduced muscle mass and physical performance in “Dietary strategies to augment muscle mass in the elderly”. Dissertation, Wageningen University, 2013.

41.

Kado DM, Bucur A, Selhub J et al. Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging. The American journal of medicine 2002;113: 537–542CrossRefPubMed

42.

Swart KM, van Schoor NM, Heymans MW et al. Elevated homocysteine levels are associated with low muscle strength and functional limitations in older persons. The journal of nutrition, health & aging 2013;17: 578–584CrossRef

43.

Weiss N, Keller C, Hoffmann U et al. Endothelial dysfunction and atherothrombosis in mild hyperhomocysteinemia. Vascular medicine 2002;7: 227–239CrossRefPubMed

Titel: Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults
verfasst von: S. ter Borg
Y. C. Luiking
A. van Helvoort
Y. Boirie
J. M. G. A. Schols
C. P. G. M. de Groot
Publikationsdatum: 13.10.2018
Verlag: Springer Paris
Erschienen in: The journal of nutrition, health & aging / Ausgabe 1/2019
Print ISSN: 1279-7707
Elektronische ISSN: 1760-4788
DOI: https://doi.org/10.1007/s12603-018-1108-3

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Low Levels of Branched Chain Amino Acids, Eicosapentaenoic Acid and Micronutrients are Associated with Low Muscle Mass, Strength and Function in Community-Dwelling Older Adults

Abstract

Background

Objective

Design

Results

Conclusion

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Abstract

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