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International Journal of Clinical Oncology
Erschienen in:

08.08.2017 | Original Article

Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma

verfasst von: Ho Won Kang, Sung Pil Seo, Won Tae Kim, Seok Joong Yun, Sang-Cheol Lee, Wun-Jae Kim, Eu Chang Hwang, Seok Ho Kang, Sung-Hoo Hong, Jinsoo Chung, Tae Gyun Kwon, Hyeon Hoe Kim, Cheol Kwak, Seok-Soo Byun, Yong-June Kim, The KORCC (KOrean Renal Cell Carcinoma) group

Erschienen in: International Journal of Clinical Oncology | Ausgabe 1/2018

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Abstract

Background

The prognostic implications of preoperative serum total cholesterol (TC) level in patients with renal cell carcinoma (RCC) remain poorly understood. We investigated the prognostic role of preoperative serum TC in patients with surgically treated RCC from a large, multi-institutional Korean collaboration.

Patients and methods

A database of 3064 patients with RCC who underwent radical or partial nephrectomy between 1999 and 2011 at eight academic centers was analyzed. Preoperative serum TC levels were measured in fasting blood samples.

Results

Low preoperative serum TC level was associated with aggressive tumor characteristics, including large tumor size, advanced stage, high nuclear grade, lymph node involvement, and sarcomatous differentiation (all P < 0.001). Low TC level was associated with poor recurrence-free or cancer-specific survival (CSS) in the entire cohort, whereas the significance of the association changed after stratification by disease stage and histologic subtype. Multivariate Cox regression analysis showed that preoperative TC, as a continuous or categorical variable, was an independent predictor of CSS.

Conclusions

Preoperative low serum TC level was associated with aggressive tumor characteristics and poor CSS in patients with surgically treated RCC. Preoperative TC may provide additional guidance regarding the choice of therapeutic strategies to improve prognosis.
Literatur
1.
Verhoest G, Veillard D, Guillé F et al (2007) Relationship between age at diagnosis and clinicopathologic features of renal cell carcinoma. Eur Urol 51(5):1298–1305CrossRefPubMed
2.
Chen L, Li H, Gu L et al (2015) The impact of diabetes mellitus on renal cell carcinoma prognosis: a meta-analysis of cohort studies. Medicine 94(26):e1055CrossRefPubMedPubMedCentral
3.
Ljungberg B, Bensalah K, Canfield S et al (2015) EAU guidelines on renal cell carcinoma: 2014 update. Eur Urol 67(5):913–924CrossRefPubMed
4.
Lee HW, Jeon HG, Jeong BC et al (2015) Diagnostic and prognostic significance of radiologic node-positive renal cell carcinoma in the absence of distant metastases: a retrospective analysis of patients undergoing nephrectomy and lymph node dissection. J Korean Med Sci 30(9):1321–1327CrossRefPubMedPubMedCentral
5.
Fujioka T, Obara W (2012) Evidence-based clinical practice guideline for renal cell carcinoma: the Japanese Urological Association 2011 update. Int J Urol 19(6):496–503CrossRefPubMed
6.
Donat SM, Diaz M, Bishoff JT et al (2013) Follow-up for clinically localized renal neoplasms: AUA guideline. J Urol 190(2):407–416CrossRefPubMed
7.
Ha Y-S, Kim WT, Yun S-J et al (2013) Multi-institutional analysis of localized renal cell carcinoma that demonstrates the impact of diabetic status on prognosis after nephrectomy. Ann Surg Oncol 20(11):3662–3668CrossRefPubMed
8.
Psutka SP, Stewart SB, Boorjian SA et al (2014) Diabetes mellitus is independently associated with an increased risk of mortality in patients with clear cell renal cell carcinoma. J Urol 192(6):1620–1627CrossRefPubMed
9.
Choi Y, Park B, Jeong BC et al (2013) Body mass index and survival in patients with renal cell carcinoma: a clinical-based cohort and meta-analysis. Int J Cancer 132(3):625–634CrossRefPubMed
10.
Parker AS, Lohse CM, Cheville JC et al (2006) Greater body mass index is associated with better pathologic features and improved outcome among patients treated surgically for clear cell renal cell carcinoma. Urology 68(4):741–746CrossRefPubMed
11.
Bono P, Elfving H, Utriainen T et al (2009) Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma. Ann Oncol 20(2):393–394CrossRefPubMed
12.
Drabkin HA, Gemmill RM (2012) Cholesterol and the development of clear-cell renal carcinoma. Curr Opin Pharmacol 12(6):742–750CrossRefPubMed
13.
14.
Ohno Y, Nakashima J, Nakagami Y et al (2014) Clinical implications of preoperative serum total cholesterol in patients with clear cell renal cell carcinoma. Urology 83(1):154–158CrossRefPubMed
15.
Martino M, Leitner CV, Seemann C et al (2015) Preoperative serum cholesterol is an independent prognostic factor for patients with renal cell carcinoma (RCC). BJU Int 115(3):397–404CrossRefPubMed
16.
17.
Byun S-S, Hong SK, Lee S et al (2016) The establishment of KORCC (KOrean Renal Cell Carcinoma) database. Invest Clin Urol 57(1):50–57CrossRef
18.
Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471–1474CrossRefPubMed
19.
Fuhrman SA, Lasky LC, Limas C (1982) Prognostic significance of morphologic parameters in renal cell carcinoma. Am J Surg Pathol 6(7):655–664CrossRefPubMed
20.
21.
Dandona P, Aljada A, Chaudhuri A et al (2005) Metabolic syndrome. Circulation 111(11):1448–1454CrossRefPubMed
22.
Cheville JC, Lohse CM, Zincke H et al (2003) Comparisons of outcome and prognostic features among histologic subtypes of renal cell carcinoma. Am J Surg Pathol 27(5):612–624CrossRefPubMed
23.
Srigley JR, Delahunt B, Eble JN et al (2013) The International Society of Urological Pathology (ISUP) Vancouver classification of renal neoplasia. Am J Surg Pathol 37(10):1469–1489CrossRefPubMed
24.
Takagi K, Yagi T, Umeda Y et al (2017) Preoperative Controlling Nutritional Status (CONUT) score for assessment of prognosis following hepatectomy for hepatocellular carcinoma. World J Surg 41(9):2353–2360CrossRefPubMed
25.
Ishihara H, Kondo T, Yoshida K et al (2017) Preoperative controlling nutritional status (CONUT) score as a novel predictive biomarker of survival in patients with localized urothelial carcinoma of the upper urinary tract treated with radical nephroureterectomy. Urol Oncol. doi:10.​1016/​j.​urolonc.​2017.​04.​012
26.
Ko K, Park YH, Lee JW et al (2013) Influence of nutritional deficiency on prognosis of renal cell carcinoma (RCC). BJU Int 112(6):775–780CrossRefPubMed
27.
Toyokawa T, Kubo N, Tamura T et al (2016) The pretreatment Controlling Nutritional Status (CONUT) score is an independent prognostic factor in patients with resectable thoracic esophageal squamous cell carcinoma: results from a retrospective study. BMC cancer 16(1):722CrossRefPubMedPubMedCentral
28.
Haddad AQ, Jiang L, Cadeddu JA et al (2015) Statin use and serum lipid levels are associated with survival outcomes after surgery for renal cell carcinoma. Urology 86(6):1146–1152CrossRefPubMed
29.
McKay RR, Lin X, Albiges L et al (2016) Statins and survival outcomes in patients with metastatic renal cell carcinoma. Eur J Cancer 52:155–162CrossRefPubMed
30.
Chae YK, Yousaf M, Malecek M-K et al (2015) Statins as anti-cancer therapy; can we translate preclinical and epidemiologic data into clinical benefit? Discov Med 20(112):413–427PubMed
Metadaten
Titel
Low preoperative serum cholesterol level is associated with aggressive pathologic features and poor cancer-specific survival in patients with surgically treated renal cell carcinoma
verfasst von
Ho Won Kang
Sung Pil Seo
Won Tae Kim
Seok Joong Yun
Sang-Cheol Lee
Wun-Jae Kim
Eu Chang Hwang
Seok Ho Kang
Sung-Hoo Hong
Jinsoo Chung
Tae Gyun Kwon
Hyeon Hoe Kim
Cheol Kwak
Seok-Soo Byun
Yong-June Kim
The KORCC (KOrean Renal Cell Carcinoma) group
Publikationsdatum
08.08.2017
Verlag
Springer Japan
Erschienen in
International Journal of Clinical Oncology / Ausgabe 1/2018
Print ISSN: 1341-9625
Elektronische ISSN: 1437-7772
DOI
https://doi.org/10.1007/s10147-017-1172-4

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