Skip to main content
Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 8/2018

14.11.2017 | Knee

Low re-rupture rate with BPTB autograft and semitendinosus gracilis autograft with preserved insertions in ACL reconstruction surgery in sports persons

verfasst von: Ravi Gupta, Munish Sood, Anubhav Malhotra, Gladson David Masih, Anil Kapoor, Mukta Raghav, Mehar Dhillon

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 8/2018

Einloggen, um Zugang zu erhalten

Abstract

Purpose

To compare the results of bone-patellar tendon-bone graft (BPTB), semitendinosus–gracilis graft with preserved insertions (STGPI) and semitendinosus–gracilis-free graft (STGF) in terms of graft failure, objective mechanical stability, functional outcome, and return to sports in elite and recreational sports persons. It was hypothesized that the STGPI graft provided superior outcome as compared to the other two grafts.

Methods

Two hundred and forty-nine elite and recreational players who underwent ACL reconstruction surgery, with BPTB graft (N = 80), STGPI graft (N = 85), and STGF graft (N = 84) with a minimum follow-up of 2 years, were assessed using clinical tests, knee arthrometer (KT 1000™), single-leg hop test, Lysholm knee score, Tegner’s activity scale, and return to sports. Groups were matched in terms of age, gender, mode of injury, side involved, the level of sports, associated injuries, and mean follow-up.

Results

The median age of the patients was 24 years (range 16–46 years), with 227 males and 22 females, with a mean follow-up of 61.8 ± 25.9 months. At the final follow-up, the mean side-to-side difference by KT 1000™ was significantly superior in BPTB group (1.4 ± 2.1 mm) as compared to STGPI (1.9 ± 2.0 mm) and STGF group (2.5 ± 2.0 mm) (p = 0.002). The mean Lysholm knee score, Limb symmetry index (LSI) using single-leg hop test and the mean difference in pre-injury and post-surgery level of Tegner’s activity scale were not significantly different. The rate of graft failure was significantly higher in STGF group (7.1%) as compared to BPTB (1.2%) and STGPI (1.2%) groups (p = 0.043).

Conclusion

BPTB graft is a better graft in terms of mechanical stability than STGPI and STGF grafts. STGPI graft and BPTB graft are superior to STGF graft in terms of graft failure rate. However, there is no statistically significant difference amongst the three grafts in terms of return to sports and clinical tests of instability. STGPI graft is another option in the clinical setting with low graft failure rate like that of BPTB graft and with the added advantage of not having significant donor site morbidity.

Level of evidence

III.
Literatur
1.
Zurück zum Zitat Aglietti P, Giron F, Buzzi R, Biddau F, Sasso F (2004) Anterior cruciate ligament reconstruction: bone-patellar tendon-bone compared with double semitendinosus and gracilis tendon grafts. J Bone Jt Surg Am 86:2143–2155CrossRef Aglietti P, Giron F, Buzzi R, Biddau F, Sasso F (2004) Anterior cruciate ligament reconstruction: bone-patellar tendon-bone compared with double semitendinosus and gracilis tendon grafts. J Bone Jt Surg Am 86:2143–2155CrossRef
2.
Zurück zum Zitat Beaufils P, Gaudot F, Drain O, Boisrenoult P, Pujol N (2011) Mini-invasive technique for bone patellar tendon bone harvesting: its superiority in reducing anterior knee pain following ACL reconstruction. Curr Rev Musculoskelet Med 4:45–51CrossRefPubMedPubMedCentral Beaufils P, Gaudot F, Drain O, Boisrenoult P, Pujol N (2011) Mini-invasive technique for bone patellar tendon bone harvesting: its superiority in reducing anterior knee pain following ACL reconstruction. Curr Rev Musculoskelet Med 4:45–51CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Beynnon BD, Johnson RJ, Fleming BC, Kannus P, Kaplan M, Samani J, Renström P (2002) Anterior cruciate ligament replacement: comparison of bone-patellar tendon-bone grafts with two-strand hamstring grafts. J Bone Jt Surg Am 84:1503–1513CrossRef Beynnon BD, Johnson RJ, Fleming BC, Kannus P, Kaplan M, Samani J, Renström P (2002) Anterior cruciate ligament replacement: comparison of bone-patellar tendon-bone grafts with two-strand hamstring grafts. J Bone Jt Surg Am 84:1503–1513CrossRef
4.
Zurück zum Zitat Bourke HE, Salmon LJ, Waller A, Patterson V, Pinczewski LA (2012) Survival of the anterior cruciate ligament graft and the contralateral ACL at a minimum of 15 years. Am J Sports Med 40:1985–1992CrossRefPubMed Bourke HE, Salmon LJ, Waller A, Patterson V, Pinczewski LA (2012) Survival of the anterior cruciate ligament graft and the contralateral ACL at a minimum of 15 years. Am J Sports Med 40:1985–1992CrossRefPubMed
5.
Zurück zum Zitat Brand J, Weiler A, Caborn D, Johnson D, Brown C (2000) Graft fixation in cruciate ligament surgery: current concepts. Am J Sports Med 28:761–774CrossRefPubMed Brand J, Weiler A, Caborn D, Johnson D, Brown C (2000) Graft fixation in cruciate ligament surgery: current concepts. Am J Sports Med 28:761–774CrossRefPubMed
6.
Zurück zum Zitat Buck B, Resnick L, Shah S, Malinin T (1990) Human immunodeficiency virus cultured from bone: implications for transplantation. ClinOrthopRelat Res 251:249–253 Buck B, Resnick L, Shah S, Malinin T (1990) Human immunodeficiency virus cultured from bone: implications for transplantation. ClinOrthopRelat Res 251:249–253
7.
Zurück zum Zitat Della Villa F, Ricci M, Persida F, Filardo G, Gamberini J, Caminati D, Della Villa S (2015) Anterior cruciate ligament reconstruction and rehabilitation: predictors of functional outcome. Joints 3(4):179–185CrossRef Della Villa F, Ricci M, Persida F, Filardo G, Gamberini J, Caminati D, Della Villa S (2015) Anterior cruciate ligament reconstruction and rehabilitation: predictors of functional outcome. Joints 3(4):179–185CrossRef
8.
Zurück zum Zitat de Valk EJ, Moen MH, Winters M, Bakker EW, Tamminga R, van der Hoeven H (2013) Preoperative patient and injury factors of successful rehabilitation after anterior cruciate ligament reconstruction with single-bundle techniques. Arthroscopy 29:1879–1895CrossRefPubMed de Valk EJ, Moen MH, Winters M, Bakker EW, Tamminga R, van der Hoeven H (2013) Preoperative patient and injury factors of successful rehabilitation after anterior cruciate ligament reconstruction with single-bundle techniques. Arthroscopy 29:1879–1895CrossRefPubMed
9.
Zurück zum Zitat Eajazi A, Madadi F, Madadi F, Boreiri M (2013) Comparison of different methods of femoral fixation anterior cruciate ligament reconstruction. Acta Med Iran 51(7):444–448PubMed Eajazi A, Madadi F, Madadi F, Boreiri M (2013) Comparison of different methods of femoral fixation anterior cruciate ligament reconstruction. Acta Med Iran 51(7):444–448PubMed
10.
Zurück zum Zitat Ejerhed L, Kartus J, Sernert N, Köhler K, Karlsson J (2003) Patellar tendon or semitendinosus tendon autografts for anterior cruciate ligament reconstruction? A prospective randomized study with a two-year follow-up. Am J Sports Med 31:19–25CrossRefPubMed Ejerhed L, Kartus J, Sernert N, Köhler K, Karlsson J (2003) Patellar tendon or semitendinosus tendon autografts for anterior cruciate ligament reconstruction? A prospective randomized study with a two-year follow-up. Am J Sports Med 31:19–25CrossRefPubMed
11.
Zurück zum Zitat Eriksson K, Anderberg P, Hamberg P, Löfgren A, Bredenberg M, Westman I, Wredmark T (2001) A comparison of quadruple semitendinosus and patellar tendon grafts in reconstruction of the anterior cruciate ligament. Bone Jt J 83:348–354CrossRef Eriksson K, Anderberg P, Hamberg P, Löfgren A, Bredenberg M, Westman I, Wredmark T (2001) A comparison of quadruple semitendinosus and patellar tendon grafts in reconstruction of the anterior cruciate ligament. Bone Jt J 83:348–354CrossRef
12.
Zurück zum Zitat Evans S, Shaginaw J, Bartolozzi A (2014) ACL reconstruction—it’s all about timing. Int J Sports PhysTher9(2):268–273 Evans S, Shaginaw J, Bartolozzi A (2014) ACL reconstruction—it’s all about timing. Int J Sports PhysTher9(2):268–273
13.
Zurück zum Zitat Gifstad T, Sole A, Strand T, Uppheim G, Grontvedt T, Drogset JO (2013) Long-term follow-up of patellar tendon grafts or hamstring tendon grafts in endoscopic ACL reconstructions. Knee Surg Sports Traumatol Arthrosc 21:576–583CrossRefPubMed Gifstad T, Sole A, Strand T, Uppheim G, Grontvedt T, Drogset JO (2013) Long-term follow-up of patellar tendon grafts or hamstring tendon grafts in endoscopic ACL reconstructions. Knee Surg Sports Traumatol Arthrosc 21:576–583CrossRefPubMed
14.
Zurück zum Zitat Gupta R, Bahadur R, Malhotra A, Masih GD, Gupta P (2016) Anterior cruciate ligament reconstruction using hamstring tendon autograft with preserved insertions. Arthrosc Tech 5:e269–e274CrossRef Gupta R, Bahadur R, Malhotra A, Masih GD, Gupta P (2016) Anterior cruciate ligament reconstruction using hamstring tendon autograft with preserved insertions. Arthrosc Tech 5:e269–e274CrossRef
15.
Zurück zum Zitat Gupta R, Kapoor D, Kapoor L, Malhotra A, Masih GD, Kapoor A, Joshi S (2016) Immediate post-operative pain in anterior cruciate ligament reconstruction surgery with bone patellar tendon bone graft versus hamstring graft. J Orthop Surg Res 11:1CrossRef Gupta R, Kapoor D, Kapoor L, Malhotra A, Masih GD, Kapoor A, Joshi S (2016) Immediate post-operative pain in anterior cruciate ligament reconstruction surgery with bone patellar tendon bone graft versus hamstring graft. J Orthop Surg Res 11:1CrossRef
16.
Zurück zum Zitat Gupta RK, Aggarwal S, Aggarwal V, Garg SK, Kumar S (2010) Preserved insertions of the semitendinosus and gracilis tendons (STG) in ACL reconstruction: a new surgical technique with preliminary results. Current Orthop Practice 21:409–414CrossRef Gupta RK, Aggarwal S, Aggarwal V, Garg SK, Kumar S (2010) Preserved insertions of the semitendinosus and gracilis tendons (STG) in ACL reconstruction: a new surgical technique with preliminary results. Current Orthop Practice 21:409–414CrossRef
17.
Zurück zum Zitat Hefti E, Müller W, Jakob R, Stäubli H-U (1993) Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc 1:226–234CrossRefPubMed Hefti E, Müller W, Jakob R, Stäubli H-U (1993) Evaluation of knee ligament injuries with the IKDC form. Knee Surg Sports Traumatol Arthrosc 1:226–234CrossRefPubMed
18.
Zurück zum Zitat Heijne A, Hagstromer M, Werner S (2015) A two- and five-year follow-up of clinical outcome after ACL reconstruction using BPTB or hamstring tendon grafts: a prospective intervention outcome study. Knee Surg Sports Traumatol Arthrosc 23:799–807CrossRefPubMed Heijne A, Hagstromer M, Werner S (2015) A two- and five-year follow-up of clinical outcome after ACL reconstruction using BPTB or hamstring tendon grafts: a prospective intervention outcome study. Knee Surg Sports Traumatol Arthrosc 23:799–807CrossRefPubMed
19.
Zurück zum Zitat Järvelä T, Kannus P, Järvinen M (2000) Anterior knee pain 7 years after an anterior cruciate ligament reconstruction with a bone patellar tendon bone autograft. Scand J Med Sci Sports 10:221–227CrossRefPubMed Järvelä T, Kannus P, Järvinen M (2000) Anterior knee pain 7 years after an anterior cruciate ligament reconstruction with a bone patellar tendon bone autograft. Scand J Med Sci Sports 10:221–227CrossRefPubMed
20.
Zurück zum Zitat Kaeding CC, Aros B, Pedroza A, Pifel E, Amendola A, Andrish JT, Spindler KP (2011) Allograft versus autograft anterior cruciate ligament reconstruction: predictors of failure from a MOON prospective longitudinal cohort. Sports Health 3(1):73–81CrossRefPubMedPubMedCentral Kaeding CC, Aros B, Pedroza A, Pifel E, Amendola A, Andrish JT, Spindler KP (2011) Allograft versus autograft anterior cruciate ligament reconstruction: predictors of failure from a MOON prospective longitudinal cohort. Sports Health 3(1):73–81CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Kautzner J, Kos P, Hanus M, Trc T, Havlas V (2015) A comparison of ACL reconstruction using patellar tendon versus hamstring autograft in female patients: a prospective randomised study. Int Orthop 39:125–130CrossRefPubMed Kautzner J, Kos P, Hanus M, Trc T, Havlas V (2015) A comparison of ACL reconstruction using patellar tendon versus hamstring autograft in female patients: a prospective randomised study. Int Orthop 39:125–130CrossRefPubMed
22.
Zurück zum Zitat Kraeutler MJ, Bravman JT, McCarty EC (2013) Bone–patellar tendon–bone autograft versus allograft in outcomes of anterior cruciate ligament reconstruction a meta-analysis of 5182 patients. Am J Sports Med 41:2439–2448CrossRefPubMed Kraeutler MJ, Bravman JT, McCarty EC (2013) Bone–patellar tendon–bone autograft versus allograft in outcomes of anterior cruciate ligament reconstruction a meta-analysis of 5182 patients. Am J Sports Med 41:2439–2448CrossRefPubMed
23.
Zurück zum Zitat Leys T, Salmon L, Waller A, Linklater J, Pinczewski L (2012) Clinical results and risk factors for reinjury 15 years after anterior cruciate ligament reconstruction a prospective study of hamstring and patellar tendon grafts. Am J Sports Med 40:595–605CrossRefPubMed Leys T, Salmon L, Waller A, Linklater J, Pinczewski L (2012) Clinical results and risk factors for reinjury 15 years after anterior cruciate ligament reconstruction a prospective study of hamstring and patellar tendon grafts. Am J Sports Med 40:595–605CrossRefPubMed
24.
Zurück zum Zitat Lund B, Nielsen T, Faunø P, Christiansen SE, Lind M (2014) Is quadriceps tendon a better graft choice than patellar tendon? A prospective randomized study. Arthroscopy 30:593–598CrossRefPubMed Lund B, Nielsen T, Faunø P, Christiansen SE, Lind M (2014) Is quadriceps tendon a better graft choice than patellar tendon? A prospective randomized study. Arthroscopy 30:593–598CrossRefPubMed
25.
Zurück zum Zitat Marimuthu K, Joshi N, Sharma M, Sharma CS, Bhargava R, Rajawat AS, Rangdal SS (2011) Anterior cruciate ligament reconstruction using the medial third of the patellar tendon. J Orthop Surg 19:221CrossRef Marimuthu K, Joshi N, Sharma M, Sharma CS, Bhargava R, Rajawat AS, Rangdal SS (2011) Anterior cruciate ligament reconstruction using the medial third of the patellar tendon. J Orthop Surg 19:221CrossRef
26.
Zurück zum Zitat Mascarenhas R, Tranovich MJ, Kropf EJ, Fu FH, Harner CD (2012) Bone-patellar tendon-bone autograft versus hamstring autograft anterior cruciate ligament reconstruction in the young athlete: a retrospective matched analysis with 2–10 year follow-up. Knee Surg Sports Traumatol Arthrosc 20:1520–1527CrossRefPubMed Mascarenhas R, Tranovich MJ, Kropf EJ, Fu FH, Harner CD (2012) Bone-patellar tendon-bone autograft versus hamstring autograft anterior cruciate ligament reconstruction in the young athlete: a retrospective matched analysis with 2–10 year follow-up. Knee Surg Sports Traumatol Arthrosc 20:1520–1527CrossRefPubMed
27.
Zurück zum Zitat Persson A, Fjeldsgaard K, Gjertsen J-E, Kjellsen AB, Engebretsen L, Hole RM, Fevang JM (2014) Increased risk of revision with hamstring tendon grafts compared with patellar tendon grafts after anterior cruciate ligament reconstruction a study of 12,643 patients from the norwegian cruciate ligament registry, 2004–2012. Am J Sports Med 42:285–291CrossRefPubMed Persson A, Fjeldsgaard K, Gjertsen J-E, Kjellsen AB, Engebretsen L, Hole RM, Fevang JM (2014) Increased risk of revision with hamstring tendon grafts compared with patellar tendon grafts after anterior cruciate ligament reconstruction a study of 12,643 patients from the norwegian cruciate ligament registry, 2004–2012. Am J Sports Med 42:285–291CrossRefPubMed
28.
Zurück zum Zitat Pinczewski LA, Lyman J, Salmon LJ, Russell VJ, Roe J, Linklater J (2007) A 10-year comparison of anterior cruciate ligament reconstructions with hamstring tendon and patellar tendon autograft a controlled, prospective trial. Am J Sports Med 35:564–574CrossRefPubMed Pinczewski LA, Lyman J, Salmon LJ, Russell VJ, Roe J, Linklater J (2007) A 10-year comparison of anterior cruciate ligament reconstructions with hamstring tendon and patellar tendon autograft a controlled, prospective trial. Am J Sports Med 35:564–574CrossRefPubMed
29.
Zurück zum Zitat Reinhardt KR, Hetsroni I, Marx RG (2010) Graft selection for anterior cruciate ligament reconstruction: a level I systematic review comparing failure rates and functional outcomes. OrthopClin North Am 41:249–262CrossRef Reinhardt KR, Hetsroni I, Marx RG (2010) Graft selection for anterior cruciate ligament reconstruction: a level I systematic review comparing failure rates and functional outcomes. OrthopClin North Am 41:249–262CrossRef
30.
Zurück zum Zitat Rodeo SA, Arnoczky SP, Torzilli PA, Hidaka C, Warren RF (1993) Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog. J Bone Jt Surg Am 75:1795–1803CrossRef Rodeo SA, Arnoczky SP, Torzilli PA, Hidaka C, Warren RF (1993) Tendon-healing in a bone tunnel. A biomechanical and histological study in the dog. J Bone Jt Surg Am 75:1795–1803CrossRef
32.
Zurück zum Zitat Shaerf DA, Pastides PS, Sarraf KM, Willis-Owen CA (2014) Anterior cruciate ligament reconstruction best practice: a review of graft choice. World J Orthop 5(1):23–29CrossRefPubMedPubMedCentral Shaerf DA, Pastides PS, Sarraf KM, Willis-Owen CA (2014) Anterior cruciate ligament reconstruction best practice: a review of graft choice. World J Orthop 5(1):23–29CrossRefPubMedPubMedCentral
33.
Zurück zum Zitat Shino K, Nakata K, Horibe S, Inoue M, Nakagawa S (1993) Quantitative evaluation after arthroscopic anterior cruciate ligament reconstruction allograft versus autograft. Am J Sports Med 21:609–616CrossRefPubMed Shino K, Nakata K, Horibe S, Inoue M, Nakagawa S (1993) Quantitative evaluation after arthroscopic anterior cruciate ligament reconstruction allograft versus autograft. Am J Sports Med 21:609–616CrossRefPubMed
34.
Zurück zum Zitat Tambe A, Godsiff S, Mulay S, Joshi M (2006) Anterior cruciate ligament insufficiency: does delay in index surgery affect outcome in recreational athletes. Int Orthop 30:104–109CrossRefPubMedPubMedCentral Tambe A, Godsiff S, Mulay S, Joshi M (2006) Anterior cruciate ligament insufficiency: does delay in index surgery affect outcome in recreational athletes. Int Orthop 30:104–109CrossRefPubMedPubMedCentral
35.
Zurück zum Zitat Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 198:42–49 Tegner Y, Lysholm J (1985) Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res 198:42–49
36.
Zurück zum Zitat Thomeé R, Neeter C, Gustavsson A, Thomeé P, Augustsson J, Eriksson B, Karlsson J (2012) Variability in leg muscle power and hop performance after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 20:1143–1151CrossRefPubMed Thomeé R, Neeter C, Gustavsson A, Thomeé P, Augustsson J, Eriksson B, Karlsson J (2012) Variability in leg muscle power and hop performance after anterior cruciate ligament reconstruction. Knee Surg Sports Traumatol Arthrosc 20:1143–1151CrossRefPubMed
37.
Zurück zum Zitat Valeriani M, Restuccia D, Lazzaro V, Franceschi F, Fabbriciani C, Tonali P (1999) Clinical and neurophysiological abnormalities before and after reconstruction of the anterior cruciate ligament of the knee. Acta Neurol Scand 99:303–307CrossRefPubMed Valeriani M, Restuccia D, Lazzaro V, Franceschi F, Fabbriciani C, Tonali P (1999) Clinical and neurophysiological abnormalities before and after reconstruction of the anterior cruciate ligament of the knee. Acta Neurol Scand 99:303–307CrossRefPubMed
38.
Zurück zum Zitat Wagner M, Kääb MJ, Schallock J, Haas NP, Weiler A (2005) Hamstring tendon versus patellar tendon anterior cruciate ligament reconstruction using biodegradable interference fit fixation a prospective matched-group analysis. Am J Sports Med 33:1327–1336CrossRefPubMed Wagner M, Kääb MJ, Schallock J, Haas NP, Weiler A (2005) Hamstring tendon versus patellar tendon anterior cruciate ligament reconstruction using biodegradable interference fit fixation a prospective matched-group analysis. Am J Sports Med 33:1327–1336CrossRefPubMed
39.
Zurück zum Zitat Weiler A, Scheffler S, Südkamp N (2000) Current aspects of anchoring hamstring tendon transplants in cruciate ligament surgery. Der Chirurg ZeitschriftfüralleGebiete der operativenMedizen 71:1034CrossRef Weiler A, Scheffler S, Südkamp N (2000) Current aspects of anchoring hamstring tendon transplants in cruciate ligament surgery. Der Chirurg ZeitschriftfüralleGebiete der operativenMedizen 71:1034CrossRef
40.
Zurück zum Zitat Xie X, Xiao Z, Li Q, Zhu B, Chen J, Chen H, Yang F, Chen Y, Lai Q, Liu X (2015) Increased incidence of osteoarthritis of knee joint after ACL reconstruction with bone–patellar tendon–bone autografts than hamstring autografts: a meta-analysis of 1,443 patients at a minimum of 5 years. Eur J Orthop Surg Traumatol 25:149–159CrossRefPubMed Xie X, Xiao Z, Li Q, Zhu B, Chen J, Chen H, Yang F, Chen Y, Lai Q, Liu X (2015) Increased incidence of osteoarthritis of knee joint after ACL reconstruction with bone–patellar tendon–bone autografts than hamstring autografts: a meta-analysis of 1,443 patients at a minimum of 5 years. Eur J Orthop Surg Traumatol 25:149–159CrossRefPubMed
Metadaten
Titel
Low re-rupture rate with BPTB autograft and semitendinosus gracilis autograft with preserved insertions in ACL reconstruction surgery in sports persons
verfasst von
Ravi Gupta
Munish Sood
Anubhav Malhotra
Gladson David Masih
Anil Kapoor
Mukta Raghav
Mehar Dhillon
Publikationsdatum
14.11.2017
Verlag
Springer Berlin Heidelberg
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 8/2018
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-017-4790-5

Weitere Artikel der Ausgabe 8/2018

Knee Surgery, Sports Traumatology, Arthroscopy 8/2018 Zur Ausgabe

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.