Background
Methods
Study design and setting
Population and data sources
Statistical analysis
Results
Study population
General characteristics
Severity of the infection within 6 h of ED admission | |||
---|---|---|---|
All patients | Infection group | Sepsis group | |
Demographics | |||
N (%) | 886 (100) | 454 (51.2) | 432 (48.8) |
Male (%) | 462 (52.1) | 232 (51.1) | 230 (53.2) |
Mean age (min-max) | 80 (22–102) | 80 (22–100) | 79 (25–102) |
Immunosuppressiona (%) | 131 (14.8) | 53 (11.7) | 78 (18.1) |
Outcomes | |||
ICU admissions (%) | 80 (9.0) | 7 (1.5) | 73 (16.9) |
ICU stay of ≥3 days (%) | 59 (73.8) | 4 (57.1) | 55 (75.3) |
Mortality at 48 h (%) | 25 (2.8) | 2 (0.4) | 23 (5.3) |
Focus of infection | |||
Respiratory (%) | 486 (54.9) | 209 (46.0) | 277 (64.1) |
Genitourinatory (%) | 178 (20.1) | 111 (24.5) | 67 (15.5) |
Gastrointestinal (%) | 115 (13.0) | 74 (16.3) | 41 (9.5) |
Skin/joint (%) | 66 (7.5) | 48 (10.6) | 18 (4.2) |
Central nervous system (%) | 8 (0.9) | 1 (0.2) | 7 (1.6) |
Endocarditis (%) | 4 (0.5) | 2 (0.4) | 2 (0.5) |
Other (%) | 17 (1.9) | 5 (1.1) | 12 (2.8) |
Unknownb (%) | 12 (1.4) | 5 (1.1) | 7 (1.6) |
All patients | ICU admission | ICU stay ≥ 3 days | Mortality at 48 h | |
---|---|---|---|---|
N (%) | 886 (100) | 80 (9) | 59 (73.8) | 25 (2.8) |
Prehospital setting | ||||
qSOFA score ≥ 2 (%) | 165 (18.6) | 29 (36.3) | 8 (13.6) | 17 (68.0) |
SIRS criteria (%) | 437 (49.3) | 55 (68.8) | 44 (74.6) | 16 (64.0) |
Sepsis definition (%) | 234 (26.4) | 40 (50.0) | 32 (54.2) | 13 (52.0) |
ED’s triage | ||||
qSOFA score ≥ 2 (%) | 149 (16.8) | 25 (31.3) | 18 (30.5) | 15 (60.0) |
SIRS criteria (%) | 374 (42.2) | 47 (58.8) | 34 (57.6) | 20 (80.0) |
Sepsis definition (%) | 221 (24.9) | 34 (42.5) | 25 (42.4) | 15 (60.0) |
Sensitivity of the clinical tools in the prehospital setting
ICU admission | ICU stay ≥ 3 days | Mortality at 48 h | |
---|---|---|---|
Prehospital setting (%;IQR) | |||
qSOFA score ≥ 2 | 36.3 (26.6–47.2) | 17.4 (9.1–30.7) | 68.0 (48.4–82.8) |
SIRS criteria | 68.8 (57.9–77.9) | 74.6 (62.2–84) | 64.0 (44.5–79.8) |
Sepsis definition | 50 (39.3–60.7) | 54.2 (41.7–66.3) | 52.0 (33.5–70) |
ED’s triage (%;IQR) | |||
qSOFA score ≥ 2 | 31.2 (22.2–42.1) | 30.5 (20.3–43.2) | 60.0 (40.7–76.6) |
SIRS criteria | 58.8 (47.8–68.9) | 57.6 (44.9–69.4) | 80.0 (60.9–91.1) |
Sepsis definition | 42.5 (32.3–53.4) | 42.4 (30.6–55.1%) | 60.0 (40.7–76.6) |