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01.12.2012 | Original investigation | Ausgabe 1/2012 Open Access

Cardiovascular Diabetology 1/2012

Low serum magnesium concentrations are associated with a high prevalence of premature ventricular complexes in obese adults with type 2 diabetes

Zeitschrift:
Cardiovascular Diabetology > Ausgabe 1/2012
Autoren:
Liana C Del Gobbo, Yiqing Song, Paul Poirier, Eric Dewailly, Ronald J Elin, Grace M Egeland
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1475-2840-11-23) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

ED and GE conceived and designed the Cree health study and contributed to critical review of analysis and interpretation of data; YS, PP and RE critically reviewed the statistical design, analysis and interpretation of data; LD conducted the statistical analysis, drafted the manuscript and was responsible for its content. All authors read and approved the final manuscript.

Abstract

Background

Premature ventricular complexes (PVC) predict cardiovascular mortality among several adult populations. Increased arrhythmia prevalence has been reported during controlled magnesium (Mg) depletion studies in adults. We thus hypothesized that serum magnesium (sMg) concentrations are inversely associated with the prevalence of PVC in adults at high cardiovascular risk.

Methods

Anthropometric, demographic and lifestyle characteristics were assessed in 750 Cree adults, aged > 18 yrs, who participated in an age-stratified, cross-sectional health survey in Quebec, Canada. Holter electrocardiograms recorded heart rate variability and cardiac arrhythmias for two consecutive hours. Multivariate logistic regression was used to evaluate the associations between sMg and PVC.

Results

PVC prevalence in adults with hypomagnesemia (sMg ≤ 0.70 mmol/L) was more than twice that of adults without hypomagnesemia (50% vs. 21%, p = 0.015); results were similar when adults with cardiovascular disease history were excluded. All hypomagnesemic adults with PVC had type 2 diabetes (T2DM). Prevalence of PVC declined across the sMg concentration gradient in adults with T2DM only (p < 0.001 for linear trend). In multivariate logistic regressions adjusted for age, sex, community, body mass index, smoking, physical activity, alcohol consumption, kidney disease, antihypertensive and cholesterol lowering drug use, and blood docosahexaenoic acid concentrations, the odds ratio of PVC among T2DM subjects with sMg > 0.70 mmol/L was 0.24 (95% CI: 0.06-0.98) p = 0.046 compared to those with sMg ≤ 0.70 mmol/L.

Conclusions

sMg concentrations were inversely associated with the prevalence of PVC in patients with T2DM in a dose response manner, indicating that suboptimal sMg may be a contributor to arrhythmias among patients with T2DM.
Zusatzmaterial
Additional file 1: Adjusted odds ratios and 95% confidence intervals for presence of > 6 PVC/hr on Holter monitors across the sMg concentration range (n = 750). (DOC 36 KB)
12933_2012_449_MOESM1_ESM.DOC
Additional file 2: Odds ratios for the fully adjusted model (Model 5) for presence of > 6 PVC/hr on Holters are minimized using < 0.75 mmol/L sMg as the reference (n = 750). (DOC 30 KB)
12933_2012_449_MOESM2_ESM.DOC
Authors’ original file for figure 1
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Authors’ original file for figure 2
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Literatur
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