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Current Reviews in Musculoskeletal Medicine

Erschienen in:

30.06.2018 | Prosthetic Joint Infection (S Nodzo and N Frisch, section editors)

Low-Virulence Organisms and Periprosthetic Joint Infection—Biofilm Considerations of These Organisms

verfasst von: K. Keely Boyle, Stuart Wood, T. David Tarity

Erschienen in: Current Reviews in Musculoskeletal Medicine | Ausgabe 3/2018

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Abstract

Purpose of Review

The purpose of this manuscript is to provide a critical review of peer-reviewed literature over the last 5 years related to low virulent organisms associated with periprosthetic joint infection (PJI). We evaluated the most common organisms, the diagnostic challenges, and the novel tools available in the perioperative workup of PJI as well as the current understanding of how biofilm potentiates the indolent clinical presentation and explore a possible shift in the surgical management of these patients.

Recent Findings

Biofilm actively prevents macrophage phagocytosis by suppressing proinflammatory activity through the recruitment of myeloid-derived suppressor cells. Given the appropriate host and organism conditions, increased utilization of one-stage exchange arthroplasty in the surgical treatment of these low virulent infections may be on the rise.

Summary

Biomarkers and molecular techniques offer encouraging results to diagnose low virulent organisms and future research focused on the disruption of biofilm may ultimately give rise to improved treatment strategies.

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Titel: Low-Virulence Organisms and Periprosthetic Joint Infection—Biofilm Considerations of These Organisms
verfasst von: K. Keely Boyle
Stuart Wood
T. David Tarity
Publikationsdatum: 30.06.2018
Verlag: Springer US
Erschienen in: Current Reviews in Musculoskeletal Medicine / Ausgabe 3/2018
Elektronische ISSN: 1935-9748
DOI: https://doi.org/10.1007/s12178-018-9503-2

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Springer Medizin

Low-Virulence Organisms and Periprosthetic Joint Infection—Biofilm Considerations of These Organisms

Abstract

Purpose of Review

Recent Findings

Summary

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Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

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