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05.09.2020 | Original Article

Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome

verfasst von: Eun Mi Yang, Kee Hwan Yoo, Yo Han Ahn, Seong Heon Kim, Jung Won Lee, Woo Yeong Chung, Min Hyun Cho, Kee Hyuck Kim, Heeyeon Cho, Mee Jeong Lee, Jin-Soon Suh, Hye Sun Hyun, Jiwon M. Lee, Myung Hyun Cho, Ji Hyun Kim, Il-Soo Ha, Hae Il Cheong, Hee Gyung Kang

Erschienen in: Pediatric Nephrology | Ausgabe 3/2021

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Abstract

Background

Children with nephrotic syndrome (NS) are at an increased risk of acute kidney injury (AKI) and the incidence of AKI in this population is reportedly increasing. This study aimed to investigate the incidence, clinical profiles, and risk factors of AKI in hospitalized children with NS through a nationwide study.

Methods

This retrospective multicenter study included 14 pediatric nephrology centers in Korea. From 2013 to 2017, a total of 814 patients with idiopathic NS were cared for at participating centers. Among them, 363 patients were hospitalized for NS and investigated in this study.

Results

A total of 363 children with NS were hospitalized 574 times. AKI occurred in 93 admissions (16.2%) of 89 patients: 30 (32.3%) stage 1; 24 (25.8%) stage 2; and 39 (41.9%) stage 3. Multivariate logistic regression analysis showed that longer disease duration, lower albumin level, and methylprednisolone pulse treatment were significantly associated with AKI development in hospitalized children with NS. AKI was associated with a longer hospital stay than non-AKI (median 10 vs. 7 days, P = 0.001). Among 93 admissions, 85 (91.4%) episodes recovered from AKI without complication, whereas 6 (6.5%) progressed to advanced chronic kidney disease (CKD).

Conclusions

AKI is not uncommon in hospitalized children with NS, and its incidence in this nationwide study was 16.2%. Risk factors for AKI in hospitalized children with NS include longer disease duration, lower albumin level, and methylprednisolone pulse therapy. Pediatric NS patients with these characteristics should be under more strict scrutiny for the occurrence of AKI.

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Titel: Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome
verfasst von: Eun Mi Yang
Kee Hwan Yoo
Yo Han Ahn
Seong Heon Kim
Jung Won Lee
Woo Yeong Chung
Min Hyun Cho
Kee Hyuck Kim
Heeyeon Cho
Mee Jeong Lee
Jin-Soon Suh
Hye Sun Hyun
Jiwon M. Lee
Myung Hyun Cho
Ji Hyun Kim
Il-Soo Ha
Hae Il Cheong
Hee Gyung Kang
Publikationsdatum: 05.09.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Nephrology / Ausgabe 3/2021
Print ISSN: 0931-041X
Elektronische ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-020-04740-y

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Lower albumin level and longer disease duration are risk factors of acute kidney injury in hospitalized children with nephrotic syndrome

Abstract

Background

Methods

Results

Conclusions

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Background

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