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22.02.2016 | Note

Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells

verfasst von: Yhiya M. Amen, Qinchang Zhu, Hai-Bang Tran, Mohamed S. Afifi, Ahmed F. Halim, Ahmed Ashour, Amira Mira, Kuniyoshi Shimizu

Erschienen in: Journal of Natural Medicines | Ausgabe 3/2016

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Abstract

A new oxygenated lanostane-type triterpene, named lucidumol C, together with six known compounds, was isolated from the chloroform extract of the fruiting bodies of Ganoderma lingzhi. Structures were established based on extensive spectroscopic and chemical studies. Potential cytotoxic activities of the isolated compounds were evaluated against human colorectal carcinoma (HCT-116, Caco-2), human liver carcinoma (HepG2), and human cervical carcinoma (HeLa) cell lines using WST-1 reagent. Selectivity was evaluated using normal human fibroblast cells (TIG-1 and HF19). Among the compounds, lucidumol C showed potent selective cytotoxicity against HCT-116 cells with an IC₅₀ value of 7.86 ± 4.56 µM and selectivity index (SI) >10 with remarkable cytotoxic activities against Caco-2, HepG2 and HeLa cell lines.

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Titel: Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells
verfasst von: Yhiya M. Amen
Qinchang Zhu
Hai-Bang Tran
Mohamed S. Afifi
Ahmed F. Halim
Ahmed Ashour
Amira Mira
Kuniyoshi Shimizu
Publikationsdatum: 22.02.2016
Verlag: Springer Japan
Erschienen in: Journal of Natural Medicines / Ausgabe 3/2016
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI: https://doi.org/10.1007/s11418-016-0976-2

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Springer Medizin

Lucidumol C, a new cytotoxic lanostanoid triterpene from Ganoderma lingzhi against human cancer cells

Abstract

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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