Background
Methods
Data sources
NSW population data
Patterns of Care (POC) data
Statistical analysis
Ethical approval
Results
NSW population data
NSW population data, diagnosed 2001–2007 | Patterns of Care (POC) data, diagnosed 2001–2010 | ||||||
---|---|---|---|---|---|---|---|
Non-Aboriginal | Aboriginal | Aboriginal | |||||
n | % | n | % |
p-valuea
| n | % | |
All people | 19,813 | 341 | 219 | ||||
Sex | |||||||
Male | 12,540 | 63 | 191 | 56 | 0.006 | 122 | 56 |
Female | 7273 | 37 | 150 | 44 | 97 | 44 | |
Age at diagnosis (years) | <0.001 | ||||||
18–49 | 930 | 5 | 39 | 11 | 31 | 14 | |
50–59 | 2609 | 13 | 79 | 23 | 65 | 30 | |
60–69 | 5292 | 27 | 110 | 32 | 71 | 32 | |
70–79 | 7117 | 36 | 87 | 26 | 45 | 21 | |
80+ | 3865 | 20 | 26 | 8 | 7 | 3 | |
Spread of disease (from CCR)b
| 0.586 | ||||||
Localised | 4602 | 23 | 79 | 23 | 40 | 22 | |
Regional | 3352 | 17 | 67 | 20 | 42 | 23 | |
Distant | 7281 | 37 | 118 | 35 | 67 | 37 | |
Unknown | 4578 | 23 | 77 | 23 | 30 | 17 | |
Place of residence at diagnosisb
| <0.001 | ||||||
Major cities | 13,687 | 69 | 125 | 37 | 77 | 43 | |
Inner regional | 4637 | 23 | 122 | 36 | 60 | 34 | |
Ruralc
| 1489 | 8 | 94 | 28 | 42 | 23 | |
Comorbiditiesd
| |||||||
Diabetes | 2735 | 15 | 67 | 20 | 0.004 | 46 | 27 |
Cardiovascular disease | 3999 | 21 | 85 | 26 | 0.055 | 35 | 21 |
Chronic pulmonary disease | 5381 | 29 | 132 | 40 | <0.001 | 35 | 38 |
Renal disease | 899 | 5 | 23 | 7 | 0.070 | 10 | 6 |
Any other comorbidities | 2380 | 13 | 39 | 12 | 0.624 | 27 | 16 |
Socioeconomic disadvantage quintileb
| <0.001 | ||||||
Least disadvantaged | 3031 | 15 | 22 | 6 | 12 | 7 | |
Second least disadvantaged | 4041 | 20 | 31 | 9 | 15 | 8 | |
Third least advantaged | 3375 | 17 | 44 | 13 | 36 | 20 | |
Second most disadvantaged | 4476 | 23 | 74 | 22 | 33 | 18 | |
Most disadvantaged | 4890 | 25 | 170 | 50 | 83 | 46 | |
Smoking status | <0.001 | ||||||
Current smoker | 5582 | 28 | 143 | 42 | 101 | 46 | |
Ever smokere
| 5934 | 30 | 99 | 29 | 61 | 28 | |
Former smoker | 4237 | 21 | 56 | 16 | 23 | 11 | |
Never smoker | 3623 | 18 | 35 | 10 | 22 | 10 | |
Unknown | 437 | 2 | 8 | 2 | 12 | 5 | |
Histological type (from CCR)b
| 0.059 | ||||||
Non-small cell | 16,369 | 83 | 273 | 80 | 142 | 79 | |
Small cell | 2533 | 13 | 57 | 17 | 34 | 19 | |
Other and unspecified | 911 | 5 | 11 | 3 | 3 | 2 | |
Method of diagnosis (from CCR)b
| 0.58 | ||||||
Histopathology | 14,205 | 72 | 251 | 74 | 139 | 78 | |
Cytology | 2832 | 14 | 42 | 12 | 17 | 10 | |
Clinical/Imaging/Biochemical | 2776 | 14 | 48 | 14 | 23 | 13 |
Surgical treatment for non-metastatic NSCLC
Odds ratioc (95 % CI) |
p-value | |
---|---|---|
Aboriginal | 0.70 (0.46–1.05) | 0.084 |
Sex | 0.042 | |
Male | 1.00 | |
Female | 1.12 (1.00–1.24) | |
Age at diagnosis (years) | <0.001 | |
18–49 | 1.00 | |
50–59 | 0.89 (0.68–1.15) | |
60–69 | 0.90 (0.70–1.14) | |
70–79 | 0.58 (0.46–0.74) | |
80+ | 0.20 (0.15–0.27) | |
Spread of disease | <0.001 | |
Localised | 1.00 | |
Regional | 0.81 (0.73–0.90) | |
Year of diagnosis | 1.04 (1.02–1.07) | 0.001 |
Place of residence at diagnosis | <0.001 | |
Major cities | 1.00 | |
Inner regional | 0.69 (0.60–0.80) | |
Rurald
| 0.66 (0.51–0.83) | |
Comorbiditiese
| ||
Chronic pulmonary disease | 1.04 (0.93–1.16) | 0.526 |
Diabetes | 1.08 (0.93–1.25) | 0.300 |
Cardiovascular disease | 0.71 (0.62–0.82) | <0.001 |
Renal disease | 0.74 (0.56–0.97) | 0.029 |
Other comorbidities | 0.60 (0.49–0.72) | <0.001 |
Socioeconomic disadvantage quintile | <0.001 | |
Least disadvantaged | 1.00 | |
Second least disadvantaged | 0.86 (0.73–1.02) | |
Third least disadvantaged | 0.73 (0.61–0.87) | |
Second most disadvantaged | 0.85 (0.72–1.01) | |
Most disadvantaged | 0.63 (0.51–0.76) |
Aboriginal | Non-Aboriginal | ||
---|---|---|---|
Had surgery n/N (%) | Had surgery n/N (%) |
p-valueb
| |
All people | 37/120 (30) | 2666/6757 (39) | - |
Sex | 0.972 | ||
Male | 21/72 (29) | 1637/4335 (38) | |
Female | 16/48 (33) | 1029/2422 (42) | |
Age at diagnosis (years) | 0.367 | ||
18–59 | 13/40 (33) | 613/1210 (51) | |
60+ | 24/80 (30) | 2053/5547 (37) | |
Spread of disease | 0.831 | ||
Localised | 20/64 (31) | 1584/3928 (40) | |
Regional | 17/56 (30) | 1082/2829 (38) | |
Place of residence | 0.641 | ||
Major cities | 13/39 (33) | 2044/4760 (43) | |
Inner regional | 13/44 (30) | 480/1498 (32) | |
Ruralc
| 11/37 (30) | 142/499 (28) | |
Comorbiditiesd
| 0.018 | ||
No comorbidities | 9/41 (22) | 1390/3196 (43) | |
At least one comorbidity | 28/79 (35) | 1276/3561 (36) | |
Socioeconomic disadvantage | 0.245 | ||
Least and second least disadvantaged | 5/15 (33) | 1095/2477 (44) | |
Third least disadvantaged | 3/16 (19) | 464/1168 (40) | |
Second most and most disadvantaged | 29/89 (33) | 1107/3112 (36) |
Risk of death from NSCLC
Variable name | Subhazard ratiob (95 % CI) | p-value |
---|---|---|
Aboriginal | 1.32 (1.14–1.52) | <0.001 |
Sex | 0.001 | |
Male | 1.00 | |
Female | 1.07 (1.03–1.11) | |
Age at diagnosis | <0.001 | |
18–50 | 1.00 | |
50–59 | 1.22 (1.11–1.35) | |
60–69 | 1.32 (1.20–1.45) | |
70–79 | 1.51 (1.37–1.66) | |
> =80 | 1.89 (1.71–2.09) | |
Spread of disease | <0.001 | |
Localised | 1.00 | |
Regional | 1.46 (1.37–1.55) | |
Distant | 2.58 (2.44–2.73) | |
Unknown | 1.13 (1.06–1.20) | |
Year of diagnosis | 0.97 (0.96–0.98) | <0.001 |
Surgical treatmentc
| <0.001 | |
Did not have surgical treatment | 1.00 | |
Had surgical treatment | 0.27 (0.25–0.28) | |
Place of residence at diagnosis | 0.889 | |
Major cities | 1.00 | |
Inner regional | 0.99 (0.94–1.05) | |
Rurald
| 1.01 (0.93–1.10) | |
Comorbiditiese
| ||
Diabetes | 1.00 (0.94–1.06) | 0.976 |
Cardiovascular disease | 0.98 (0.93–1.04) | 0.575 |
Chronic pulmonary disease | 1.18 (1.12–1.23) | <0.001 |
Renal disease | 0.94 (0.84–1.05) | 0.280 |
Other comorbidities | 1.14 (1.07–1.22) | <0.001 |
Socioeconomic disadvantage quintile | <0.001 | |
Least disadvantaged | 1.00 | |
Second least disadvantaged | 1.04 (0.98–1.11) | |
Third least disadvantaged | 1.17 (1.09–1.25) | |
Second most disadvantaged | 1.11 (1.04–1.19) | |
Most disadvantaged | 1.12 (1.04–1.20) | |
Smoking status | 0.149 | |
Never smoker | 1.00 | |
Current smoker | 1.03 (0.98–1.08) | |
Ever smoker | 1.06 (1.00–1.12) | |
Ex smoker | 0.99 (0.93–1.05) | |
Unknown | 1.01 (0.87–1.17) |
Patterns of care data
Treatment received for NSCLC
Surgerya +/− radiotherapy/chemotherapy | Potentially curative radiotherapy/chemotherapy | Palliative radiotherapy/chemotherapy | No treatment | ||
---|---|---|---|---|---|
Spread of disease | N | Number (%) | Number (%) | Number (%) | Number (%) |
Non-metastatic | 94 | 34 (36) | 13 (14) | 26 (28) | 21 (22) |
Metastatic | 71 | 1 (1) | 1 (1) | 51 (72) | 18 (25) |
Unknown spread | 5 | - | - | - | 5 (100) |
Total | 170 | 35 (21) | 14 (8) | 77 (45) | 44 (26) |