nach oben

01.09.2009 | Original Article | Ausgabe 9/2009

Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer

Zeitschrift:: International Journal of Colorectal Disease > Ausgabe 9/2009

Autoren:: M. Ishii, M. Ota, S. Saito, Y. Kinugasa, S. Akamoto, I. Ito

Abstract

Objective

When selecting patients who are at high risk for lymph node metastasis, the detection of lymphatic vessel invasion (LVI) is important. We investigated LVI detected by D2-40 staining as a predictor of lymph node metastasis in T1 colorectal cancer.

Materials and methods

Clinicopathological factors including LVI were investigated in 136 patients who underwent colectomy with lymph node dissection for T1 colorectal cancer. We used immunostaining with monoclonal antibody D2-40 to detect LVI.

Results

Lymph node metastases were found in 18 patients (13.2%), and LVI were detected in 45 (33%); lymph node metastasis was more frequently observed in LVI-positive groups (13/45 vs 5/91, p < 0.001). Both univariate and multivariate analyses revealed that LVI detected by D2-40 and a poorly differentiated histology at the invasion front were independent risk factors of lymph node metastasis.

Conclusion

LVI detected by D2-40 is important for the prediction of lymph node metastasis.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Jetzt einloggen Kostenlos registrieren

★ PREMIUM-INHALT

e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt gratis testen * Jetzt kaufen

Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

e.Med Innere Medizin

Kombi-Abonnement

Mit e.Med Innere Medizin erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes Innere Medizin, den Premium-Inhalten der internistischen Fachzeitschriften, inklusive einer gedruckten internistischen Zeitschrift Ihrer Wahl.

Jetzt testen ¹

e.Med Chirurgie

Kombi-Abonnement

Mit e.Med Chirurgie erhalten Sie Zugang zu CME-Fortbildungen des Fachgebietes Chirurgie, den Premium-Inhalten der chirurgischen Fachzeitschriften, inklusive einer gedruckten chirurgischen Zeitschrift Ihrer Wahl.

Jetzt testen ²

Hurlstone DP, Cross SS, Drew K, Adam I, Shorthouse AJ, Brown S, Sanders DS, Lobo AJ (2004) An evaluation of colorectal endoscopic mucosal resection using high-magnification chromoscopic colonoscopy: a prospective study of 1,000 colonoscopies. Endoscopy 36:491–498 PubMedCrossRef

Hurlstone DP, Atkinson R, Sanders DS, Thomson M, Cross SS, Brown S (2007) Achieving R0 resection in the colorectum using endoscopic submucosal dissection. Br J Surg 94:1536–1542 PubMedCrossRef

Bories E, Pesenti C, Monges G, Lelong B, Moutardier V, Delpero JR, Giovannini M (2006) Endoscopic mucosal resection for advanced sessile adenoma and early-stage colorectal carcinoma. Endoscopy 2006(38):231–235 CrossRef

Wilcox GM, Anderson PB, Colacchio TA (1986) Early invasive carcinoma in colonic polyps: a review of the literature with emphasis on the assessment of the risk of metastasis. Cancer 57:160–171 PubMedCrossRef

Tanaka S, Haruma K, Teixeira CR, Tatsuta S, Ohtsu N, Hiraga Y, Yoshihara M, Sumii K, Kajiyama G, Shimamoto F (1995) Endoscopic treatment of submucosal invasive colorectal carcinoma with special reference to risk factors for lymph node metastasis. J Gastroenterol 91:419–427

Okabe S, Shia J, Nash G, Wong WD, Guillem JG, Weiser MR, Temple L, Sugihara K, Paty PB (2004) Lymph node metastasis in T1 adenocarcinoma of the colon and rectum. J Gastrointest Surg 8:1032–1039 PubMedCrossRef

Nivatvongs S, Roianasakul A, Reiman HM, Dozois RR, Wolff BG, Pemberton JH, Beartt RW, Jacques LF (1991) The risk of lymph node metastasis in colorectal polyps with invasive adenocarcinoma. Dis Colon Rectum 34:323–328 PubMedCrossRef

Wang HS, Liang WY, Lin TC, Chen WS, Jiang JK, Yang SH, Chang SC, Lin JK (2005) Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Dis Colon Rectum 48:1182–1192 PubMedCrossRef

Ishikawa Y, Akishima-Fukasawa Y, Ito K, Akasaka Y, Yokoo T, Ishii T (2008) Histopathologic determinants of regional lymph node metastasis in early colorectal cancer. Cancer 112:924–933 PubMedCrossRef

10.

Sakuragi M, Togashi K, Konishi F, Koinuma K, Kawamura Y, Okada M, Nagai H (2003) Predictive factors for lymph node metastasis in T1 stage colorectal carcinomas. Dis Colon Rectum 46:1626–1632 PubMedCrossRef

11.

Nascimbeni R, Burgart LJ, Nivatvongs S, Larson DR (2002) Risk of lymph node metastasis in T1 carcinoma of the colon and rectum. Dis Colon Rectum 45:200–206 PubMedCrossRef

12.

Kitajima K, Fujimori T, Fujii S, Takeda J, Ohkura Y, Kawamata H, Kumamoto T, Ishiguro S, Kato Y, Shimoda T, Iwashita A, Ajioka Y, Watanabe H, Watanabe T, Muto T, Nagasako K (2004) Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study. J Gastroenterol 39:534–543 PubMedCrossRef

13.

Tominaga K, Nakanishi Y, Nimura S, Yoshimura K, Sakai Y, Shimoda T (2005) Predictive histopathologic factors for lymph node metastasis in patients with nonpedunculated submucosal invasive colorectal carcinoma. Dis Colon Rectum 48:92–100 PubMedCrossRef

14.

Compton C, Fenoglio-Preiser CM, Pettigrew N, Fielding LP (2000) American joint committee on cancer prognostic factors consensus conference: colorectal working group. Cancer 88:1739–1757 PubMedCrossRef

15.

Kahn HJ, Marks A (2002) A new monoclonal antibody, D2–40, for detection of lymphatic invasion in primary tumors. Lab Invest 82:1255–1257 PubMed

16.

Fogt F, Zimmerman RL, Ross HM, Daly T, Gausas RE (2004) Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40. Oncol Rep 11:47–50 PubMed

17.

Haggitt RC, Glotzbach RE, Soffer EE, Wruble LD (1985) Prognostic factors in colorectal carcinomas arising in adenomas: implications for lesions removed by endoscopic polypectomy. Gastroenterology 89:328–336 PubMed

18.

Kudo S (1993) Endoscopic mucosal resection of flat and depressed types of early colorectal cancer. Endoscopy 25:455–461 PubMedCrossRef

19.

Saad RS, Kordunsky L, Liu YL, Denning KL, Kandil HA, Silverman JF (2006) Lymphatic microvessel density as prognostic marker in colorectal cancer. Mod Pathol 19:1317–1323 PubMedCrossRef

20.

Kazama S, Watanabe T, Ajioka Y, Kanazawa T, Nagawa H (2006) Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2. Br J Cancer 94:293–298 PubMedCrossRef

21.

Ueno H, Mochizuki H, Hashiguchi Y, Shimazaki H, Aida S, Hase K, Matsukuma S, Kanai T, Kurihara H, Ozawa K, Yoshimura K, Bekku S (2004) Risk factors for an adverse outcome in early invasive colorectal carcinoma. Gastroenterology 127:385–394 PubMedCrossRef

22.

Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC (2002) Tumour ‘budding’ as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 40:127–132 PubMedCrossRef

23.

Morodomi T, Isomoto H, Shirouzu K, Kakegawa K, Irie K, Morimatsu M (1989) An index for estimating the probability of lymph node metastasis in rectal cancers: lymph node metastasis and the histopathology of actively invasive regions of cancer. Cancer 63:539–543 PubMedCrossRef

24.

Okuyama T, Oya M, Ishikawa H (2002) Budding as a risk factor for lymph node metastasis in pT1 or pT2 well-differentiated colorectal adenocarcinoma. Dis Colon Rectum 45:628–634 PubMedCrossRef

25.

Okuyama T, Oya M, Ishikawa H (2003) Budding as a useful prognostic marker in pT3 well- or moderately-differentiated rectal adenocarcinoma. J Surg Oncol 83:42–47 PubMedCrossRef

26.

Walgenbach-Bruenagel G, Tolba RH, Varnai AD, Bollmann M, Hirner A, Walgenbach KJ (2006) Detection of lymphatic invasion in early stage primary colorectal cancer with the monoclonal antibody D2-40. Eur Surg Res 38:438–444 PubMedCrossRef

27.

Yasuda K, Inomata M, Shirouzu A, Shiraishi N, Higashi H, Kitano S (2007) Risk factors for occult lymph node metastasis of colorectal cancer invading the submucosa and indications for endoscopic mucosal resection. Dis Colon Rectum 50:1370–1376 PubMedCrossRef

28.

Abdulkader M, Abdulla K, Rakha E, Kaye P (2006) Routine elastic staining assists detection of vascular invasion in colorectal cancer. Histopathology 49:487–492 PubMedCrossRef

Titel: Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer
Autoren:: M. Ishii
M. Ota
S. Saito
Y. Kinugasa
S. Akamoto
I. Ito
Publikationsdatum: 01.09.2009
DOI: https://doi.org/10.1007/s00384-009-0699-x
Verlag: Springer-Verlag
Zeitschrift: International Journal of Colorectal Disease Clinical and Molecular Gastroenterology and Surgery
Ausgabe 9/2009
Print ISSN: 0179-1958
Elektronische ISSN: 1432-1262

Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.
Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Chirurgie

12.11.2018 | Fortbildungsveranstaltung für HNO-Ärzte 2018 | Kongressbericht | Nachrichten

Newsletter bestellen

Bildnachweise

Mail Icon II

Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer

Abstract

Objective

Materials and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Innere Medizin

e.Med Chirurgie

Gesucht: Das richtige Antibiotikum zur richtigen Zeit

Zervixkarzinom: Minimalinvasiv unterliegt offener Op.

Leistenhernien bei Frauen besser nicht offen operieren

Motivierende Fitness-Apps auch für Krebspatienten geeignet

Newsletter

Springer Medizin

Abstract

Objective

Materials and methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

e.Med Innere Medizin

e.Med Chirurgie

Weitere Artikel der Ausgabe 9/2009

Comparison of two sodium phosphate tablet-based regimens and a polyethylene glycol regimen for colon cleansing prior to colonoscopy: a randomized prospective pilot study

Determinants of morbidity and survival after elective non-curative resection of stage IV colon and rectal cancer

Double rectal perforation after stapled haemorrhoidectomy

Restorative proctocolectomy for inflammatory bowel disease

Subtotal colectomy with antiperistaltic cecoproctostomy for slow-transit constipation

ErbB family immunohistochemical expression in colorectal cancer patients with higher risk of recurrence after radical surgery

Neu im Fachgebiet Chirurgie

Gesucht: Das richtige Antibiotikum zur richtigen Zeit

Zervixkarzinom: Minimalinvasiv unterliegt offener Op.

Leistenhernien bei Frauen besser nicht offen operieren

Motivierende Fitness-Apps auch für Krebspatienten geeignet

Newsletter