Background
Methods
Study subjects
Follow-up and assessment of fracture healing
Immunohistochemistry
Image analysis
Statistical analysis
Result
Baseline characteristics of the study groups
Features | CF group | CFT group | p value |
---|---|---|---|
Number | 25 | 22 | – |
Age (years) | 36.0 ± 15.3 | 34.0 ± 15.2 | 0.657 |
Gender | 0.820* | ||
Male | 21 (84.0) | 19 (86.4) | |
Female | 4 (16.0) | 3 (15.6) | |
GCS score | 15 ± 0 | 11.5 ± 1.7383 | 0.000 |
Blood monocyte (%) | 0.922 ± 0.020 | 0.058 ± 0.035 | 0.000 |
Time from injury to surgery | 0.706* | ||
≤ 7 days | 10 (40.0) | 10 (45.5%) | |
8–14 days | 15 (60.0) | 12 (54.5%) | |
COX-2/CD68 (%) | 29.95 ± 11.90 | 33.54 ± 9.3 | 0.259 |
CD206/CD68 (%) | 20.23 ± 8.08 | 40.53 ± 18.16 | 0.000 |
The percentage of M2-type macrophages increased during repairing stage
The percentage of M2-type macrophages elevated in patients with clavicle fracture and concomitant TBI
Healing time | Age | Gender | GCS | Injury type | Surgery time after injury | Callus volume | COX2 | CD206 | Monocyte percentage | ||
---|---|---|---|---|---|---|---|---|---|---|---|
Healing time | r | 1 | 0.110 | − 0.051 | 0.746** | − 0.744** | − 0.037 | − 0.627** | − 0.192 | − 0.575** | 0.359* |
p | 0.464 | 0.733 | 0.000 | 0.000 | 0.803 | 0.000 | 0.196 | 0.000 | 0.013 | ||
Age | r | 0.110 | 1 | 0.049 | 0.084 | − 0.066 | 0.005 | 0.043 | 0.113 | − 0.116 | 0.090 |
p | 0.464 | 0.744 | 0.575 | 0.657 | 0.971 | 0.773 | 0.450 | 0.436 | 0.547 | ||
Gender | r | − 0.051 | 0.049 | 1 | − 0.074 | 0.033 | 0.123 | 0.097 | − 0.048 | 0.117 | 0.097 |
p | 0.733 | 0.744 | 0.622 | 0.825 | 0.408 | 0.518 | 0.749 | 0.433 | 0.515 | ||
GCS | r | 0.746 | 0.084 | − 0.074 | 1 | − 0.836 | − 0.268 | − 0.826 | 0.103 | − 0.785 | 0.478 |
p | 0.000 | 0.575 | 0.622 | 0.000 | 0.068 | 0.000 | 0.489 | 0.000 | 0.001 | ||
Injury type | r | − 0.744 | − 0.066 | 0.033 | − 0.836 | 1 | − 0.055 | 0.683 | 0.168 | 0.602 | − 0.520 |
p | 0.000 | 0.657 | 0.825 | 0.000 | 0.713 | 0.000 | 0.259 | 0.000 | 0.000 | ||
Time from injury to surgery | r | − 0.037 | 0.005 | 0.123 | − 0.268 | − 0.055 | 1 | 0.194 | − 0.834 | 0.665 | 0.073 |
p | 0.803 | 0.971 | 0.408 | 0.068 | 0.713 | 0.191 | 0.000 | 0.000 | 0.625 | ||
Callus volume | r | − 0.627 | 0.043 | 0.097 | − 0.826 | 0.683 | 0.194 | 1 | 0.001 | 0.720 | − 0.311 |
p | 0.000 | 0.773 | 0.518 | 0.000 | 0.000 | 0.191 | 0.995 | 0.000 | 0.033 | ||
COX2 | r | − 0.192 | 0.113 | − 0.048 | 0.103 | 0.168 | − 0.834 | 0.001 | 1 | − 0.452 | − 0.076 |
p | 0.196 | 0.450 | 0.749 | 0.489 | 0.259 | 0.000 | 0.995 | 0.001 | 0.612 | ||
CD206 | r | − 0.575 | − 0.116 | 0.117 | − 0.785 | 0.602 | 0.665 | 0.720 | − 0.452 | 1 | − 0.212 |
p | 0.000 | 0.436 | 0.433 | 0.000 | 0.000 | 0.000 | 0.000 | 0.001 | 0.152 | ||
Monocyte percentage | r | 0.359 | 0.090 | 0.097 | 0.478 | − 0.520 | 0.073 | − 0.311 | − 0.076 | − 0.212 | 1 |
p | 0.013 | 0.547 | 0.515 | 0.001 | 0.000 | 0.625 | 0.033 | 0.612 | 0.152 |