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Erschienen in: Digestive Diseases and Sciences 5/2007

01.05.2007 | Review article

Macro-Aspartate Aminotransferase and Monoclonal Gammopathy: A Review of Two Cases

verfasst von: Tuesday Werner, Hugo E. Vargas, Naga Chalasani

Erschienen in: Digestive Diseases and Sciences | Ausgabe 5/2007

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Excerpt

Aspartate aminotransferase (AST), also known as glutamic-oxaloacetic transaminase, is one of several enzymes that exist in macromolecular form as a result of their association with other molecules, generally immunoglobulins [2]. In clinical practice, elevation of AST is generally associated with hepatic pathology. Hepatologists are commonly called to make associations between elevated transaminases and any of a number of potential causes of liver disease. Macro-AST has been detected in diseases such as acute and chronic hepatitis, other autoimmune diseases, and malignancies of the stomach, breast, and prostate [3]. Herein we present two patients who presented for medical care in the setting of hematological abnormalities in whom evaluation of hepatic function was requested due to elevated AST levels; these cases illustrate the possibility of macro-AST in patients with elevated enzyme immunoglobulin G (IgG) [1]. …
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Metadaten
Titel
Macro-Aspartate Aminotransferase and Monoclonal Gammopathy: A Review of Two Cases
verfasst von
Tuesday Werner
Hugo E. Vargas
Naga Chalasani
Publikationsdatum
01.05.2007
Erschienen in
Digestive Diseases and Sciences / Ausgabe 5/2007
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-006-9555-9

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