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Erschienen in: Journal of Natural Medicines 1/2019

13.08.2018 | Original Paper

Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii

verfasst von: Dongsheng Fan, Ting Li, Zhiyuan Zheng, Guo-Yuan Zhu, Xiaojun Yao, Zhi-Hong Jiang, Li-Ping Bai

Erschienen in: Journal of Natural Medicines | Ausgabe 1/2019

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Abstract

Nine new monomacrolide sesquiterpene pyridine alkaloids, macroregelines A–I (19), were isolated from the stems of Tripterygium regelii, along with a known alkaloid, tripfordine B. The structures of all the isolated compounds were characterized by extensive one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic analyses, as well as high-resolution electrospray-ionization mass spectrometry (HRESIMS) data. Compounds 4, 5, 6, and 8 showed antiproliferative effect on human rheumatoid arthritis synovial cell line MH7A at concentration of 20 μM, reducing their viability by 7.5, 18.0, 9.0, and 18.2 %, respectively.
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Metadaten
Titel
Macrolide sesquiterpene pyridine alkaloids from the stems of Tripterygium regelii
verfasst von
Dongsheng Fan
Ting Li
Zhiyuan Zheng
Guo-Yuan Zhu
Xiaojun Yao
Zhi-Hong Jiang
Li-Ping Bai
Publikationsdatum
13.08.2018
Verlag
Springer Singapore
Erschienen in
Journal of Natural Medicines / Ausgabe 1/2019
Print ISSN: 1340-3443
Elektronische ISSN: 1861-0293
DOI
https://doi.org/10.1007/s11418-018-1232-8

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