Skip to main content
main-content

01.08.2010 | Commentary | Ausgabe 4/2010

Critical Care 4/2010

Macrolides and community-acquired pneumonia: is quorum sensing the key?

Zeitschrift:
Critical Care > Ausgabe 4/2010
Autoren:
Matt P Wise, David W Williams, Michael AO Lewis, Paul J Frost
Wichtige Hinweise

Competing interests

The authors declare that they have no competing interests.

Abstract

Combination therapy with two antimicrobial agents is superior to monotherapy in severe community-acquired pneumonia, and recent data suggest that addition of a macrolide as the second antibiotic might be superior to other combinations. This observation requires confirmation in a randomised control trial, but this group of antibiotics have pleiotropic effects that extend beyond bacterial killing. Macrolides inhibit bacterial cell-to-cell communication or quorum sensing, which not only might be an important mechanism of action for these drugs in severe infections but may also provide a novel target for the development of new anti-infective drugs.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 4/2010

Critical Care 4/2010 Zur Ausgabe

Neu im Fachgebiet AINS

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update AINS und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise