07.12.2018 | Case Based Review
Macrophage activation syndrome in a patient with axial spondyloarthritis on adalimumab
verfasst von:
Rahaf Baker, Jean W. Liew, Paul D. Simonson, Lori A. Soma, Gordon Starkebaum
Erschienen in:
Clinical Rheumatology
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Ausgabe 2/2019
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Abstract
Macrophage activation syndrome (MAS) is a rare and potentially fatal condition characterized by excessive activation and uncontrolled proliferation of T lymphocytes and macrophages, leading to overwhelming systemic inflammation and cytokine release. MAS has been reported with viral infections, autoimmune disorders, malignancies, and medications. We describe a case of a patient with axial spondyloarthritis (axSpA) treated with adalimumab, who presented with MAS.