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01.02.2012 | Pictorial Review | Ausgabe 1/2012 Open Access

Insights into Imaging 1/2012

Magnetic resonance cholangiopancreatography: the ABC of MRCP

Insights into Imaging > Ausgabe 1/2012
Nyree Griffin, Geoff Charles-Edwards, Lee Alexander Grant


It has been exactly two decades since magnetic resonance cholangiopancreatography (MRCP) was first described [ 1]. Over this time, the technique has evolved considerably, aided by improvements in spatial resolution and speed of acquisition. It has now an established role in the investigation of many biliary disorders, serving as a non-invasive alternative to endoscopic retrograde cholangiopancreatography (ERCP). It makes use of heavily T2-weighted pulse sequences, thus exploiting the inherent differences in the T2-weighted contrast between stationary fluid-filled structures in the abdomen (which have a long T2 relaxation time) and adjacent soft tissue (which has a much shorter T2 relaxation time). Static or slow moving fluids within the biliary tree and pancreatic duct appear of high signal intensity on MRCP, whilst surrounding tissue is of reduced signal intensity.
Heavily T2-weighted images were originally achieved using a gradient-echo (GRE) balanced steady-state free precession technique [ 1, 2]. A fast spin-echo (FSE) pulse sequence with a long echo time (TE) was then introduced shortly after [ 3], with the advantages of a higher signal-to-noise ratio and contrast-to-noise ratio, and a lower sensitivity to motion and susceptibility artefacts. Modified FSE sequences have been described, including rapid acquisition with rapid enhancement (RARE) [ 4], half-Fourier acquisition single-shot turbo spin-echo (HASTE) [ 5], and fast-recovery fast spin-echo (FRFSE) [ 6] sequences. Both breath-hold (using a single shot approach) [ 7] and non-breath-hold techniques (with respiratory triggering) [ 8] have been used, with images obtained either as a two-dimensional (2D) or three-dimensional (3D) acquisition. A 3D technique provides a higher signal to noise ratio, which is traded off for thinner contiguous slices. Acquiring images with near isotropic voxels allows improved post-processing manipulation of the images with multi-planar reconstruction, maximum intensity projection (MIP) and volume rendering. The introduction of faster gradients and a parallel acquisition technique has resulted in even greater spatial resolution and faster acquisition times. More recently, functional assessment of biliary excretion and pancreatic exocrine function has become possible with the use of hepatobiliary contrast media [ 9] and secretin [ 10] respectively.
The purpose of this pictorial review is to describe (1) the MRCP protocol used by our centre and additional/alternative sequences which can be employed, (2) the normal biliary anatomy on MRCP, (3) the potential pitfalls associated with this technique and (4) the main clinical indications for its use.

MRCP protocol

Patients are fasted for 4 h prior to the study in order to reduce fluid secretions within the stomach and duodenum, reduce bowel peristalsis and promote gallbladder distension. We do not routinely use an anti-peristaltic agent. Some centres use a negative oral contrast agent (e.g. iron oxide or blueberry juice) to reduce the signal intensity of overlapping fluid within the stomach and duodenum, although this is not part of our routine protocol.
At our institution, MRCP is performed on a 1.5-T Avanto MRI system (Siemens, Erlangen, Germany), using a phased-array body coil. The protocol imaging parameters are shown in Table  1. We first perform an axial 2D breath-hold HASTE sequence. Two breath-hold acquisitions are obtained, so that the whole of the liver down to the duodenal ampulla is visualised.
Table 1
Summary of MRCP imaging parameters
T2-weighted breath-hold HASTE (liver down to ampulla)
3D T2-weighted FSE with respiratory triggering
T2 weighted breath-hold HASTE fat-saturated thick slab
TR/TE (ms)
Number of averages
Flip angle
Field of view (mm)
350 × 263
380 × 380
350 × 350
Matrix size
256 × 146
384 × 380
384 × 300
Slice thickness (mm)
7 mm
1.5 mm
40 mm
Slice gap (mm)
0.7 mm
0 mm
Number of slices
Acquisition plane
Coronal oblique
Half-Fourier factor
Phase-encoding: off
Phase encoding: 7/8
Slice-encoding: 6/8
Parallel imaging acceleration factor
Receiver bandwidth (Hz/pixel)
Turbo factor
Slice: 20%
Phase: 33%
HASTE half-Fourier acquisition single shot turbo spin echo, FSE fast spin echo
Following this, we perform two 3D respiratory-triggered heavily T2-weighted FSE sequences in the coronal oblique plane. The imaging plane is selected from the initial axial T2-weighted images, with one acquisition aligned to the common bile duct (CBD) in the head of the pancreas and the second acquisition aligned to the pancreatic duct at approximately 90 degrees to the first imaging plane. Respiratory triggering is achieved with the use of a navigator sequence that employs an MR pre-pulse to monitor respiratory motion. The navigator is placed over the edge of the diaphragm on the coronal and sagittal localisers and image acquisition is triggered when the position of this diaphragm interface with the lung falls within a pre-specified acceptance window. In this way a consistent position of the imaging slice is obtained. The patient is asked to breathe regularly throughout this acquisition, which takes between 3-5 min to acquire. A stack of 40 slices are obtained, which are contiguous and each of 1.5 mm in thickness. As the images are heavily T2-weighted, the pancreatico-biliary tree is displayed as high signal intensity, whilst adjacent structures are of reduced signal intensity. This sequence is useful in detecting small filling defects or strictures in the biliary or pancreatic ducts. From this volume of data, a MIP reformat can be generated. This displays only the pixel with the highest signal intensity along a ray perpendicular to the plane of projection. It thus highlights bile-filled and fluid-filled structures very well. MIP reformats can be generated in various coronal and sagittal oblique planes. We conventionally create 18 MIP reformats at 10-degree intervals to each other over a radial array of 180 degrees.
In addition to, or as an alternative to the MIP reformats, a thick collimation slab can be obtained in the coronal plane. This involves performing a fat saturated HASTE sequence where a single slab of data 4 cm in thickness is acquired in a 1- to 2-s breath-hold. It is useful in depicting the entire pancreatico-biliary tree and no post-processing is required.
In order to evaluate the duct walls, and any focal parenchymal pathology, 3D fat suppressed T1-weighted GRE sequences before and after intravenous contrast administration can also be performed.

Secretin-stimulated MRCP

Secretin is an endogenous hormone normally produced by the duodenum, which stimulates exocrine secretion of the pancreas. When given as a synthetic agent intravenously (1 ml/10 kg body weight), it improves the visualisation of the pancreatic duct by increasing its calibre. Pancreatic juice flows out of the major duodenal papilla to progressively fill the duodenum. We perform a thick slab MRCP in the coronal oblique plane at baseline and then at 1, 3, 5, 7 and 9 min following injection. Its effect starts almost immediately and peaks between 2 to 5 mins. By 10 min, the calibre of the main pancreatic duct should return to baseline (Fig.  1a-c) with persistent dilatation of >3 mm considered abnormal. The indications for this technique include the detection and characterisation of pancreatic ductal anomalies and strictures, evaluation of the integrity of the pancreatic duct, characterisation of any communication between the pancreatic duct and pseudocysts/pancreatic fistulas, and the assessment of pancreatic function and sphincter of Oddi dysfunction.

Functional MR cholangiography

This involves the use of MR lipophilic paramagnetic contrast agents, which when given intravenously, show hepato-biliary excretion. Contrast agents include gadobenate dimeglumine (Gd-BOPTA, Multihance; Bracco Imaging, Milan, Italy), gadolinium ethoxybenzyldiethylenetriamine penta-acetic acid (Gd-EOB-DTPA, Primovist; Bayer-Schering Pharma, Berlin, Germany) and, historically, mangafodopir trisodium (Teslascan; GE Healthcare, Oslo, Norway). Delayed imaging in the axial and coronal plane, performed between 10-120 min following intravenous administration, normally results in hyper-intense bile on 3D T1-weighted fat-saturated GRE images. The signal-to-noise ratio is higher than conventional T2-weighted MRCP, allowing better delineation of the bile ducts. This technique can be used for similar indications as for T2-weighted MRCP and in most cases has a similar diagnostic accuracy. It is more expensive than conventional T2-weighted MRCP and only the biliary tree is depicted. For these reasons, most centres continue to use conventional T2-weighted MRCP. However, functional MRCP does have a number of advantages, as follows: (1) it better demonstrates communications between cystic lesions and draining bile ducts in the diagnosis of congenital biliary disorders (e.g. Caroli’s disease) [ 11], (2) it helps to distinguish true obstruction in a dilated biliary system (where delayed or no biliary excretion is demonstrated) from pseudo-obstruction [ 9], and (3) it can demonstrate active extravasation of contrast in suspected bile leaks [ 12, 13]. Another advantage is that these gadolinium-based hepatobiliary-specific contrast agents initially distribute in the extracellular fluid compartment, thus allowing for early dynamic pre-contrast and post-contrast images in the arterial, portal venous and equilibrium phase prior to the functional cholangiogram.
In cases where there is significant biliary obstruction or impaired hepatocyte function, delayed images up to 24 h can be performed until contrast is seen in the gallbladder and duodenum.

Normal anatomy on MRCP

Only central intra-hepatic bile ducts are normally seen on MRCP (Fig.  2), usually measuring up to 3 mm in diameter, whilst extra-hepatic bile ducts should not exceed 7 mm. In patients with a previous cholecystectomy, mild biliary dilatation occurs, with the CBD measuring up to 10 mm in diameter. The intra-hepatic biliary drainage system parallels the portal venous supply. The right hepatic duct has two major branches: the right posterior duct, which has an almost horizontal course (draining posterior segments VI and VII), and the right anterior duct, which has a more vertical course (draining the anterior segments V and VIII). The right posterior duct usually runs posterior to the right anterior duct and fuses with it on its left (medial) side. The left hepatic duct drains segments II-IV and joins the right hepatic duct to form the common hepatic duct. Segment 1 drains via a separate bile duct usually into the origin of the left or right hepatic duct.
The pancreatic duct should be no greater than 3 mm, with the main pancreatic duct of Wirsung normally draining into the major duodenal papilla along with the CBD (91% of individuals). An accessory pancreatic duct of Santorini may be present in 45% [ 14], which drains into the minor duodenal papilla. The cystic duct usually joins the extra-hepatic duct from the right lateral aspect in 50% of cases, although it may insert into its anterior or posterior aspect in 30% and medial aspect in 20% of individuals.

Pitfalls on MRCP

A number of pitfalls may arise which fall into four main categories: (1) artefacts related to technique and reconstruction; (2) normal variants mimicking pathology; (3) intra-ductal factors; (4) extra-ductal factors.

Technique and reconstruction artefacts

A thick slab MRCP may obscure small filling defects or strictures as the spatial resolution is degraded because of volume averaging effects. Partial volume effects also degrade spatial resolution in MIP reformats, leading to the missed filling defects (Fig.  3a, b) and over- or under-estimation of strictures. Due to respiratory motion artefact, the biliary tree may appear stenotic, dilated, disconnected or duplicated on MIP reformats. Hence it is important to always review the original thin-section data set also.

Normal variants

A long cystic duct running parallel to the CBD may simulate a dilated common duct, whilst a contracted choledochal sphincter may mimic an impacted stone or stricture in the distal CBD. En face visualisation of the cystic duct insertion into the bile duct may also simulate a filling defect. Performing MRCP in multiple imaging planes or carrying out repeat MRCP imaging will help resolve these problems.

Intra-ductal factors

Filling defects in the bile may arise, not only from bile duct calculi but also from the presence of gas, debris, haemorrhage and tumour. Aerobilia is seen as a non-dependent filling defect on the axial images (Fig.  4a, b), whilst a signal void in the central part of the bile duct is due to flow phenomenon (Fig.  4c) and may occur in dilated ducts and at the point of insertion of a large cystic duct. The presence of iodinated contrast material will also reduce the signal intensity of bile.

Extra-ductal factors

Pulsatile vascular compression from adjacent vessels may mimic a stricture. The commonest site of extrinsic vascular compression is the common hepatic duct, followed by the left hepatic duct, both due to the right hepatic artery crossing its posterior aspect (Fig.  5a, b). The mid portion of the CBD may also be narrowed due to the gastro-duodenal artery. Pseudo-obstruction is typically seen as a bandlike compression with minimal proximal dilatation. Susceptibility artefacts from metallic clips and gas may give rise to difficulties in interpretation, although titanium clips used nowadays for cholecystectomy are not magnetic. Overlapping of the biliary tree with other stationary fluids (i.e. from adjacent bowel, cystic collections or ascites) may also cause interpretation problems.

Clinical indications for MRCP

Identification of congenital anomalies of the cystic and hepatic ducts

A normal biliary anatomy is present in only about 60% of the population. There are many cystic duct variants [ 15, 16], including a low insertion, a medial insertion (Fig.  6), and drainage of the cystic duct into the right hepatic duct. The most important variant of intrahepatic bile duct branching clinically is the presence of an aberrant right posterior sectoral duct draining into the common hepatic duct or cystic duct in 5% of the population. This should be recognised on MRCP (if performed), as it may be ligated or cut at the time of cholecystectomy. The most common anatomic variant of intrahepatic bile duct branching, occurring in 13-19% of the population [ 15, 17] is drainage of the right anterior or posterior duct into the left hepatic duct (Fig.  7). This is important to detect in patients undergoing left hepatectomy for living related transplant donation as accidental ligation/resection may lead to cirrhosis of segments 5 and 8 or segments 6 and 7 respectively. A triple confluence [ 15] may also be seen (11%) where the right posterior duct, right anterior duct and left hepatic duct simultaneously drain into the common hepatic duct (Fig.  8a). When ERCP is used as the ‘gold standard’, MRCP has an accuracy of between 90 to 95% in the diagnosis of such congenital anomalies [ 16].

Post-surgical biliary anatomy and complications

ERCP is often not possible in patients with a previous biliary-enteric anastomosis. MRCP is then useful in the demonstration of post-surgical biliary anatomy and in the detection of biliary complications, with a 100% sensitivity in the diagnosis of anastomotic strictures and a 90% sensitivity for choledocholithiasis [ 18].

Pancreas divisum

This is the most common pancreatic variant and is associated with an increased prevalence of acute pancreatitis. There is failure of fusion of the dorsal and ventral pancreatic ducts. The larger dominant dorsal pancreatic duct drains the tail, body and superior head of the pancreas into the minor duodenal papilla (Fig.  9), whilst the smaller ventral duct drains the inferior pancreatic head and uncinate process into the major duodenal papilla, along with the CBD. MRCP has a 100% accuracy in the detection of this condition [ 19].

Anomalous pancreaticobiliary junction

Choledochal cysts are associated with anomalous union of the pancreaticobiliary duct, where the pancreatic duct and CBD unite outside the duodenal wall and form a long common channel greater than 15 mm in length. There are five different types of choledochal cyst described (Todani classification) with three main types of anomalous pancreaticobiliary junction. MRCP can assist detection of such variants when suspected clinically.


This is usually performed in patients presenting with obstructive liver function tests and with suspected gallstones and/or a dilated CBD on ultrasound. It is also carried out in patients who have persistent symptoms and abnormal liver function following cholecystectomy. A systematic review of the literature has shown that when compared with ERCP, MRCP has an aggregated sensitivity, specificity, positive predictive value and negative predictive value of 85%, 93%, 87%, and 82% respectively [ 20]. Stones (as small as 2 mm) appear as dependent low-signal-filling defects within the CBD (Fig.  8a, b), surrounded by high-signal-intensity bile.

Benign biliary strictures

These usually develop following surgical injury (95%) from procedures such as laparoscopic cholecystectomy, hepatic resection, liver transplantation and biliary enteric anastomosis. Other causes include trauma, inflammation from choledocholithiasis, ischaemia involving the hepatic artery and primary sclerosing cholangitis (PSC). Typically a benign stricture involves a short segment, with a regular margin and symmetric narrowing. MRCP can demonstrate the site and extent of the stricture with a reported sensitivity of 91-100% [ 21].
PSC is a fibrosing inflammatory process of the bile ducts, resulting in stenosis of both intrahepatic (80%) and extrahepatic ducts. Seventy percent of patients have inflammatory bowel disease [ 22] and 10% of patients with PSC will develop a cholangiocarcinoma. MRCP is not as sensitive as ERCP in the detection of early changes, but is useful for follow-up in established cases, in order to determine severity and to recognise the development of complications. On MRCP, the ducts appear beaded or have a ‘pruned tree’ appearance with multifocal strictures demonstrated, with intervening normal or slightly dilated ducts seen (Fig.  10a, b).

Malignant biliary strictures

Cholangiocarcinoma is a tumour arising from the bile ducts. On MRCP the periductal type is seen as a biliary stricture, involving the CBD, common hepatic duct, biliary bifurcation (Klatskin tumour) or intrahepatic ducts. Proximal bile duct dilatation occurs (Fig.  11a). Suspicious features include increased wall thickness (>3 mm), increased signal intensity on T2-weighted images (Fig.  11b) and progressive enhancement of the bile ducts (due to the fibrotic component of the tumour) following intravenous administration of gadolinium. A malignant extrahepatic bile duct stricture is likely to be longer than a benign stricture, with an irregular margin and asymmetric narrowing.
Pancreatic adenocarcinoma usually appears as a focal mass, most often in the head of the pancreas, leading to encasement and obstruction of the pancreatic duct and/or CBD. Dilatation of both ducts is seen in approximately 75% of cases appearing as the ‘double duct’ sign on MRCP (Fig.  12). Although contrast-enhanced CT is conventionally used for staging local and distant spread in pancreatic cancers, MRCP may be used as an initial investigation in identifying the level of obstruction in patients presenting with painless obstructive jaundice.
Peri-ampullary carcinoma can lead to high-grade obstruction of the CBD with abrupt termination on MRCP (Fig.  13). There is usually only mild dilatation of the pancreatic duct.

Chronic pancreatitis

Chronic inflammation of the pancreas results in parenchymal destruction with fibrosis, fat necrosis and dystrophic calcification. Strictures in the main pancreatic duct may eventually develop a ‘chain-of-lakes’ appearance with alternating stenoses and dilatation. Side branch ectasia and intraductal calculi occur (Fig.  14). In advanced cases there can be marked dilatation of both the pancreatic duct and CBD simulating the ‘double duct’ sign seen with carcinoma of the head of pancreas. The sensitivity of MRCP in the detection of early side branch changes can be increased with the use of secretin-stimulated MRCP [ 23].
Pseudocysts are encapsulated fluid collections seen in both acute and chronic pancreatitis (Figs.  5, 6). These often develop within the lesser sac. MRCP is more sensitive than ERCP in demonstrating these fluid collections and may show their connection with the pancreatic duct. With ERCP, less than 50% of pseudocysts opacify with contrast [ 24].

Cystic pancreatic tumours

Cystic pancreatic tumours include serous cystadenomas, mucinous cystic neoplasms and intraductal papillary mucinous neoplasm (IPMN). Often, small cystic lesions within the pancreas are detected incidentally on CT performed for other indications. MRCP can help delineate these tumours more clearly (Fig.  15a, b). Table  2 shows the difference in epidemiology and MRCP morphology between these cystic tumours.
Table 2
Differences in epidemiology and morphology on MRCP of cystic pancreatic tumours
Serous cystadenoma
Mucinous cystic neoplasms
Intraductal mucinous neoplasm (IPMN)
Typically older women >60 years
Typically younger women 30-50 years
Peak age 6th decade, no gender bias
Site of tumour
Anywhere in the pancreas, especially the head
75% in body/tail
Side branch type: usually pancreatic head/uncinate process, less frequently in the tail; tumour communicates with the main pancreatic duct
Main duct type: segmental or diffuse involvement of the main pancreatic duct
>6 cysts (<2 cm each), thin septations, central scar (calcification), does not communicate with the pancreatic duct
Cysts >2 cm, unilocular or multilocular, does not communicate with the pancreatic duct
Side branch type: macrocystic or microcystic appearances
Features of malignancy on MR denoted by thick septations, soft tissue nodules, and/or pancreatic duct dilatation
Main duct type: diffuse duct dilatation due to gross mucin production, micropapillary studding, pancreatic atrophy
Average size
5 cm
6-10 cm
Larger size with malignant tumours
Signal characteristics
Fluid signal
High signal intensity on T1 and T2 (mucin/blood)
High signal intensity on T1 (mucin), intermediate signal intensity on T2
Usually benign
Malignant in 50%
Side branch type: usually associated with benign adenomas
Main duct type: malignant in 40%

Biliary injuries

Following transection of the bile ducts (usually following surgery), bile accumulates within the sub-hepatic space. Fluid collections can be appreciated on MRCP with transection of the affected bile duct. If functional MRCP is used, extravasation of contrast from the biliary tree is seen. A stricture may develop following accidental ligation or transection, with upstream dilatation demonstrated on MRCP.


The technique of MRCP has evolved considerably over the last 2 decades, with technological advances in both acquisition and post processing. It remains the investigation of choice for the non-invasive diagnosis of many pancreatico-biliary disorders. It is hoped that this review has helped remind the reader as to the basic concepts behind MRCP, the different sequences that can now be employed, the pitfalls one should be aware of, and why, even in modern day, it remains a test fit for purpose in the radiological investigation of biliary pathology.
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License ( https://​creativecommons.​org/​licenses/​by/​2.​0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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