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Erschienen in: Current Cardiovascular Imaging Reports 1/2013

01.02.2013 | Molecular Imaging (ZA Fayad, Section Editor)

Magnetic Resonance Imaging of Carotid Atherosclerosis and the Risk of Stroke

verfasst von: Navneet Singh, Anna E. Zavodni, Alan R. Moody

Erschienen in: Current Cardiovascular Imaging Reports | Ausgabe 1/2013

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Abstract

Stroke attributable to carotid atherosclerosis is a leading cause of mortality and morbidity. The clinical management of carotid atherosclerosis presently relies on the degree of stenosis determined by angiography. Degree of stenosis is limited in stratifying patients’ risk of stroke. Advances in magnetic resonance imaging have resulted in the ability to directly assess atherosclerotic plaque components, morphology, and biomechanical stress levels. Components of atherosclerosis, including lipid-rich necrotic core, fibrous cap thickness/disruption, and intraplaque hemorrhage, are promising emerging indicators of stroke. Information beyond luminal stenosis from magnetic resonance imaging may allow for improved detection of patients at risk of stroke from carotid atherosclerosis. We review the recent literature on the relationship of magnetic resonance imaging detected plaque components and cerebrovascular events. Clinical applications of magnetic resonance imaging of carotid plaque components are discussed.
Literatur
1.
Zurück zum Zitat Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation. 2012;125(1):e2–e220. Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, et al. Heart disease and stroke statistics–2012 update: a report from the American Heart Association. Circulation. 2012;125(1):e2–e220.
2.
3.
Zurück zum Zitat North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–53.CrossRef North American Symptomatic Carotid Endarterectomy Trial Collaborators. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med. 1991;325:445–53.CrossRef
4.
Zurück zum Zitat Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–5.PubMedCrossRef Glagov S, Weisenberg E, Zarins CK, Stankunavicius R, Kolettis GJ. Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med. 1987;316:1371–5.PubMedCrossRef
5.
Zurück zum Zitat Kuo F, Gardener H, Dong C, Cabral D, Della-Morte D, Blanton SH, et al. Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque. Stroke. 2012;43(7):1755–60. Kuo F, Gardener H, Dong C, Cabral D, Della-Morte D, Blanton SH, et al. Traditional cardiovascular risk factors explain the minority of the variability in carotid plaque. Stroke. 2012;43(7):1755–60.
6.
Zurück zum Zitat Saam T, Cai J, Ma L, Cai YQ, Ferguson MS, Polissar NL, et al. Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging. Radiology. 2006;240:464–72.PubMedCrossRef Saam T, Cai J, Ma L, Cai YQ, Ferguson MS, Polissar NL, et al. Comparison of symptomatic and asymptomatic atherosclerotic carotid plaque features with in vivo MR imaging. Radiology. 2006;240:464–72.PubMedCrossRef
7.
Zurück zum Zitat Cappendijk VC, Kessels AG, Heeneman S, Cleutjens KB, Schurink GW, Welten RJ, et al. Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: initial results. J Magn Reson Imaging. 2008;27:1356–61.PubMedCrossRef Cappendijk VC, Kessels AG, Heeneman S, Cleutjens KB, Schurink GW, Welten RJ, et al. Comparison of lipid-rich necrotic core size in symptomatic and asymptomatic carotid atherosclerotic plaque: initial results. J Magn Reson Imaging. 2008;27:1356–61.PubMedCrossRef
8.
Zurück zum Zitat Cheung HM, Moody AR, Singh N, Bitar R, Zhan J, Leung G. Late stage complicated atheroma in low-grade stenotic carotid disease: MR imaging depiction–prevalence and risk factors. Radiology. 2011;260(3):841–7. Cheung HM, Moody AR, Singh N, Bitar R, Zhan J, Leung G. Late stage complicated atheroma in low-grade stenotic carotid disease: MR imaging depiction–prevalence and risk factors. Radiology. 2011;260(3):841–7.
9.
Zurück zum Zitat Moody AR, Bitar R, Leung G, Maggisano R. Looking beyond the lumen does make all the difference. Stroke. 2006;37(7):1648; author reply 1649. Moody AR, Bitar R, Leung G, Maggisano R. Looking beyond the lumen does make all the difference. Stroke. 2006;37(7):1648; author reply 1649.
10.
Zurück zum Zitat Moody A. Stroke: cause and effect–seek and ye shall find. JACC Cardiovasc Imaging. 2012;5(4):406–8. Moody A. Stroke: cause and effect–seek and ye shall find. JACC Cardiovasc Imaging. 2012;5(4):406–8.
11.
Zurück zum Zitat Funaki T, Iihara K, Miyamoto S, Nagatsuka K, Hishikawa T, Ishibashi-Ueda H. Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging. J Vasc Surg. 2011;53(4):977–83. Funaki T, Iihara K, Miyamoto S, Nagatsuka K, Hishikawa T, Ishibashi-Ueda H. Histologic characterization of mobile and nonmobile carotid plaques detected with ultrasound imaging. J Vasc Surg. 2011;53(4):977–83.
13.
Zurück zum Zitat Topakian R, King A, Kwon SU, Schaafsma A, Shipley M, Markus HS. Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis. Neurology. 2011;77(8):751–8. Topakian R, King A, Kwon SU, Schaafsma A, Shipley M, Markus HS. Ultrasonic plaque echolucency and emboli signals predict stroke in asymptomatic carotid stenosis. Neurology. 2011;77(8):751–8.
14.
Zurück zum Zitat Aldemir E, Apaydin M, Varer M, Uluc E. Echolucency of carotid plaques and cerebrovascular events. J Clin Ultrasound. 2012;40:399–404.PubMedCrossRef Aldemir E, Apaydin M, Varer M, Uluc E. Echolucency of carotid plaques and cerebrovascular events. J Clin Ultrasound. 2012;40:399–404.PubMedCrossRef
15.
Zurück zum Zitat Homburg PJ, Rozie S, van Gils MJ, van den Bouwhuijsen QJ, Niessen WJ, Dippel DW, et al. Association between carotid artery plaque ulceration and plaque composition evaluated with multidetector CT angiography. Stroke. 2011;42(2):367–72. Homburg PJ, Rozie S, van Gils MJ, van den Bouwhuijsen QJ, Niessen WJ, Dippel DW, et al. Association between carotid artery plaque ulceration and plaque composition evaluated with multidetector CT angiography. Stroke. 2011;42(2):367–72.
16.
Zurück zum Zitat U-King-Im JM, Fox AJ, Aviv RI, Howard P, Yeung R, Moody AR, et al. Characterization of carotid plaque hemorrhage: a CT angiography and MR intraplaque hemorrhage study. Stroke. 2010;41(8):1623–9. U-King-Im JM, Fox AJ, Aviv RI, Howard P, Yeung R, Moody AR, et al. Characterization of carotid plaque hemorrhage: a CT angiography and MR intraplaque hemorrhage study. Stroke. 2010;41(8):1623–9.
17.
Zurück zum Zitat Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, Ortiz G, et al. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation. 2001;104:2051–6.PubMedCrossRef Yuan C, Mitsumori LM, Ferguson MS, Polissar NL, Echelard D, Ortiz G, et al. In vivo accuracy of multispectral magnetic resonance imaging for identifying lipid-rich necrotic cores and intraplaque hemorrhage in advanced human carotid plaques. Circulation. 2001;104:2051–6.PubMedCrossRef
18.
Zurück zum Zitat Moody AR, Murphy RE, Morgan PS, Martel AL, Delay GS, Allder S, et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation. 2003;107(24):3047–52. Moody AR, Murphy RE, Morgan PS, Martel AL, Delay GS, Allder S, et al. Characterization of complicated carotid plaque with magnetic resonance direct thrombus imaging in patients with cerebral ischemia. Circulation. 2003;107(24):3047–52.
19.
Zurück zum Zitat Cai J, Hatsukami TS, Ferguson MS, Kerwin WS, Saam T, Chu B, et al. In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology. Circulation. 2005;112:3437–44.PubMedCrossRef Cai J, Hatsukami TS, Ferguson MS, Kerwin WS, Saam T, Chu B, et al. In vivo quantitative measurement of intact fibrous cap and lipid-rich necrotic core size in atherosclerotic carotid plaque: comparison of high-resolution, contrast-enhanced magnetic resonance imaging and histology. Circulation. 2005;112:3437–44.PubMedCrossRef
20.
Zurück zum Zitat Bitar R, Moody AR, Leung G, Symons S, Crisp S, Butany J, et al. In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage. Radiology Rsna. 2008;2008:259–67.CrossRef Bitar R, Moody AR, Leung G, Symons S, Crisp S, Butany J, et al. In vivo 3D high-spatial-resolution MR imaging of intraplaque hemorrhage. Radiology Rsna. 2008;2008:259–67.CrossRef
21.
Zurück zum Zitat Kwee RM, van Engelshoven JM, Mess WH, ter Berg JW, Schreuder FH, Franke CL, et al. Reproducibility of fibrous cap status assessment of carotid artery plaques by contrast-enhanced MRI. Stroke. 2009;40:3017–21.PubMedCrossRef Kwee RM, van Engelshoven JM, Mess WH, ter Berg JW, Schreuder FH, Franke CL, et al. Reproducibility of fibrous cap status assessment of carotid artery plaques by contrast-enhanced MRI. Stroke. 2009;40:3017–21.PubMedCrossRef
22.
Zurück zum Zitat Ota H, Yarnykh VL, Ferguson MS, Underhill HR, Demarco JK, Zhu DC, et al. Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences. Radiology. 2010;254:551–63.PubMedCrossRef Ota H, Yarnykh VL, Ferguson MS, Underhill HR, Demarco JK, Zhu DC, et al. Carotid intraplaque hemorrhage imaging at 3.0-T MR imaging: comparison of the diagnostic performance of three T1-weighted sequences. Radiology. 2010;254:551–63.PubMedCrossRef
23.
Zurück zum Zitat Singh N, Moody AR, Gladstone DJ, Leung G, Ravikumar R, Zhan J, et al. Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. Radiology. 2009;252(2):502–8. Singh N, Moody AR, Gladstone DJ, Leung G, Ravikumar R, Zhan J, et al. Moderate carotid artery stenosis: MR imaging-depicted intraplaque hemorrhage predicts risk of cerebrovascular ischemic events in asymptomatic men. Radiology. 2009;252(2):502–8.
24.
Zurück zum Zitat Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, et al. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI–initial results. Stroke. 2006;37:818–23.PubMedCrossRef Takaya N, Yuan C, Chu B, Saam T, Underhill H, Cai J, et al. Association between carotid plaque characteristics and subsequent ischemic cerebrovascular events: a prospective assessment with MRI–initial results. Stroke. 2006;37:818–23.PubMedCrossRef
25.
Zurück zum Zitat Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, Moody AR, et al. Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg. 2008;47:337–42.PubMedCrossRef Altaf N, Daniels L, Morgan PS, Auer D, MacSweeney ST, Moody AR, et al. Detection of intraplaque hemorrhage by magnetic resonance imaging in symptomatic patients with mild to moderate carotid stenosis predicts recurrent neurological events. J Vasc Surg. 2008;47:337–42.PubMedCrossRef
26.
Zurück zum Zitat Yuan C, Zhang SX, Polissar NL, Echelard D, Ortiz G, Davis JW, et al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation. 2002;105:181–5.PubMedCrossRef Yuan C, Zhang SX, Polissar NL, Echelard D, Ortiz G, Davis JW, et al. Identification of fibrous cap rupture with magnetic resonance imaging is highly associated with recent transient ischemic attack or stroke. Circulation. 2002;105:181–5.PubMedCrossRef
27.
Zurück zum Zitat • Millon A, Boussel L, Brevet M, Mathevet JL, Canet-Soulas E, Mory C, et al. Clinical and histological significance of gadolinium enhancement in carotid atherosclerotic plaque. Stroke. 2012;43(11):3023–8. doi:10.1161/STROKEAHA.112.662692. Millon confirmed gadolinium enhancement of atherosclerotic plaque is associated with type VI plaque. Millon provides insight into location of gadolinium enhancement in the plaque, the possible mechanisms by which this enhancement occurs, and suggests that fibrous cap enhancement might be a precursor to plaque rupture. • Millon A, Boussel L, Brevet M, Mathevet JL, Canet-Soulas E, Mory C, et al. Clinical and histological significance of gadolinium enhancement in carotid atherosclerotic plaque. Stroke. 2012;43(11):3023–8. doi:10.​1161/​STROKEAHA.​112.​662692. Millon confirmed gadolinium enhancement of atherosclerotic plaque is associated with type VI plaque. Millon provides insight into location of gadolinium enhancement in the plaque, the possible mechanisms by which this enhancement occurs, and suggests that fibrous cap enhancement might be a precursor to plaque rupture.
28.
Zurück zum Zitat Kwee RM, Truijman MT, van Oostenbrugge RJ, Mess WH, Prins MH, Franke CL, et al. Longitudinal MRI study on the natural history of carotid artery plaques in symptomatic patients. PLoS One. 2012;7(7):e42472. Kwee RM, Truijman MT, van Oostenbrugge RJ, Mess WH, Prins MH, Franke CL, et al. Longitudinal MRI study on the natural history of carotid artery plaques in symptomatic patients. PLoS One. 2012;7(7):e42472.
29.
Zurück zum Zitat Sun J, Underhill HR, Hippe DS, Xue Y, Yuan C, Hatsukami TS. Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study. JACC Cardiovasc Imaging. 2012;5(8):798–804. doi:10.1016/j.jcmg.2012.03.014. Sun J, Underhill HR, Hippe DS, Xue Y, Yuan C, Hatsukami TS. Sustained acceleration in carotid atherosclerotic plaque progression with intraplaque hemorrhage: a long-term time course study. JACC Cardiovasc Imaging. 2012;5(8):798–804. doi:10.​1016/​j.​jcmg.​2012.​03.​014.
30.
Zurück zum Zitat Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002;90:251–62.PubMed Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis: the good, the bad, and the ugly. Circ Res. 2002;90:251–62.PubMed
31.
Zurück zum Zitat • McNally JS, Kim SE, Yoon HC, Findeiss LK, Roberts JA, Nightingale DR, et al. Carotid magnetization-prepared rapid acquisition with gradient-echo signal is associated with acute territorial cerebral ischemic events detected by diffusion-weighted MRI. Circ Cardiovasc Imaging. 2012;5(3):376–82. Using an MP-RAGE sequence that is more sensitive to intraplaque hemorrhage compared with the traditional T1 weighted and time-of-flight sequences, McNally and colleagues demonstrated the association of intraplaque hemorrhage and stroke defined by diffusion tensor imaging. • McNally JS, Kim SE, Yoon HC, Findeiss LK, Roberts JA, Nightingale DR, et al. Carotid magnetization-prepared rapid acquisition with gradient-echo signal is associated with acute territorial cerebral ischemic events detected by diffusion-weighted MRI. Circ Cardiovasc Imaging. 2012;5(3):376–82. Using an MP-RAGE sequence that is more sensitive to intraplaque hemorrhage compared with the traditional T1 weighted and time-of-flight sequences, McNally and colleagues demonstrated the association of intraplaque hemorrhage and stroke defined by diffusion tensor imaging.
32.
Zurück zum Zitat Kwee RM, Hofman PA, Gronenschild EH, van Oostenbrugge RJ, Mess WH, ter Berg JW, et al. Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLoS One. 2011;6:e17070.PubMedCrossRef Kwee RM, Hofman PA, Gronenschild EH, van Oostenbrugge RJ, Mess WH, ter Berg JW, et al. Association between carotid plaque characteristics and cerebral white matter lesions: one-year follow-up study by MRI. PLoS One. 2011;6:e17070.PubMedCrossRef
33.
Zurück zum Zitat Qiao Y, Etesami M, Astor BC, Zeiler SR, Trout HH III, Wasserman BA. Carotid plaque neovascularization and hemorrhage detected by MR imaging are associated with recent cerebrovascular ischemic events. AJNR Am J Neuroradiol. 2012;33(4):755–60. Qiao Y, Etesami M, Astor BC, Zeiler SR, Trout HH III, Wasserman BA. Carotid plaque neovascularization and hemorrhage detected by MR imaging are associated with recent cerebrovascular ischemic events. AJNR Am J Neuroradiol. 2012;33(4):755–60.
34.
Zurück zum Zitat Yamada K, Yoshimura S, Kawasaki M, Enomoto Y, Asano T, Hara A, et al. Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging. Atherosclerosis. 2011;215(2):399–404. Yamada K, Yoshimura S, Kawasaki M, Enomoto Y, Asano T, Hara A, et al. Embolic complications after carotid artery stenting or carotid endarterectomy are associated with tissue characteristics of carotid plaques evaluated by magnetic resonance imaging. Atherosclerosis. 2011;215(2):399–404.
35.
Zurück zum Zitat • Yoshimura S, Yamada K, Kawasaki M, Asano T, Kanematsu M, Takamatsu M, et al. High-intensity signal on time-of-flight magnetic resonance angiography indicates carotid plaques at high risk for cerebral embolism during stenting. Stroke. 2011;42(11):3132–7. Yoshimura and colleagues demonstrated the ability of high-risk plaque defined by TOF high signal in the carotid plaque to be associated with embolism during carotid artery stenting. The use of a routinely used carotid imaging sequence such as TOF may be valuable in determining whether patient-centered therapy such as carotid artery stenting would benefit the patient. • Yoshimura S, Yamada K, Kawasaki M, Asano T, Kanematsu M, Takamatsu M, et al. High-intensity signal on time-of-flight magnetic resonance angiography indicates carotid plaques at high risk for cerebral embolism during stenting. Stroke. 2011;42(11):3132–7. Yoshimura and colleagues demonstrated the ability of high-risk plaque defined by TOF high signal in the carotid plaque to be associated with embolism during carotid artery stenting. The use of a routinely used carotid imaging sequence such as TOF may be valuable in determining whether patient-centered therapy such as carotid artery stenting would benefit the patient.
36.
Zurück zum Zitat Kurosaki Y, Yoshida K, Endo H, Chin M, Yamagata S. Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery. 2011;68:62–7. discussion 67.PubMedCrossRef Kurosaki Y, Yoshida K, Endo H, Chin M, Yamagata S. Association between carotid atherosclerosis plaque with high signal intensity on T1-weighted imaging and subsequent ipsilateral ischemic events. Neurosurgery. 2011;68:62–7. discussion 67.PubMedCrossRef
37.
Zurück zum Zitat • Lindsay AC, Biasiolli L, Lee JM, Kylintireas I, MacIntosh BJ, Watt H, et al. Plaque features associated with increased cerebral infarction after minor stroke and TIA: a prospective, case–control, 3-T carotid artery MR imaging study. JACC Cardiovasc Imaging. 2012;5(4):388–96. Lindsay et al. reported that patients with minor stroke or TIA have a higher proportion of complex plaque, particularly in the group with stenosis less than 70 %, compared with asymptomatic controls. Fibrous cap rupture was associated with greater FLAIR and diffusion-weighted imaging brain lesions. • Lindsay AC, Biasiolli L, Lee JM, Kylintireas I, MacIntosh BJ, Watt H, et al. Plaque features associated with increased cerebral infarction after minor stroke and TIA: a prospective, case–control, 3-T carotid artery MR imaging study. JACC Cardiovasc Imaging. 2012;5(4):388–96. Lindsay et al. reported that patients with minor stroke or TIA have a higher proportion of complex plaque, particularly in the group with stenosis less than 70 %, compared with asymptomatic controls. Fibrous cap rupture was associated with greater FLAIR and diffusion-weighted imaging brain lesions.
38.
Zurück zum Zitat • Freilinger TM, Schindler A, Schmidt C, Grimm J, Cyran C, Schwarz F, et al. Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke. JACC Cardiovasc Imaging. 2012;5(4):397–405. In up to 40 % of ischemic stroke patients, no definite etiology can be established despite extensive work-up. Freilinger et al. demonstrate that arterio-arterial embolism from complicated non-stenosing carotid atherosclerotic plaque may be the responsible etiology. • Freilinger TM, Schindler A, Schmidt C, Grimm J, Cyran C, Schwarz F, et al. Prevalence of nonstenosing, complicated atherosclerotic plaques in cryptogenic stroke. JACC Cardiovasc Imaging. 2012;5(4):397–405. In up to 40 % of ischemic stroke patients, no definite etiology can be established despite extensive work-up. Freilinger et al. demonstrate that arterio-arterial embolism from complicated non-stenosing carotid atherosclerotic plaque may be the responsible etiology.
39.
Zurück zum Zitat Yoshida K, Sadamasa N, Narumi O, Chin M, Yamagata S, Miyamoto S. Symptomatic low-grade carotid stenosis with intraplaque hemorrhage and expansive arterial remodeling is associated with a high relapse rate refractory to medical treatment. Neurosurgery. 2012;70(5):1143–50. discussion 1150–1.PubMedCrossRef Yoshida K, Sadamasa N, Narumi O, Chin M, Yamagata S, Miyamoto S. Symptomatic low-grade carotid stenosis with intraplaque hemorrhage and expansive arterial remodeling is associated with a high relapse rate refractory to medical treatment. Neurosurgery. 2012;70(5):1143–50. discussion 1150–1.PubMedCrossRef
40.
Zurück zum Zitat Du J, Wasserman BA, Tong W, Chen S, Lai S, Malhotra S, et al. Cholesterol is associated with the presence of a lipid core in carotid plaque of asymptomatic, young-to-middle-aged African Americans with and without HIV infection and cocaine use residing in inner-city Baltimore, Maryland, USA. Cerebrovasc Dis (Switzerland: Basel). 2012;33(3):295–301. doi:10.1159/000334661. Du J, Wasserman BA, Tong W, Chen S, Lai S, Malhotra S, et al. Cholesterol is associated with the presence of a lipid core in carotid plaque of asymptomatic, young-to-middle-aged African Americans with and without HIV infection and cocaine use residing in inner-city Baltimore, Maryland, USA. Cerebrovasc Dis (Switzerland: Basel). 2012;33(3):295–301. doi:10.​1159/​000334661.
41.
Zurück zum Zitat Zhao X, Underhill HR, Zhao Q, Cai J, Li F, Oikawa M, et al. Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 Tesla. Stroke. 2011;42(2):347–53. Zhao X, Underhill HR, Zhao Q, Cai J, Li F, Oikawa M, et al. Discriminating carotid atherosclerotic lesion severity by luminal stenosis and plaque burden: a comparison utilizing high-resolution magnetic resonance imaging at 3.0 Tesla. Stroke. 2011;42(2):347–53.
42.
Zurück zum Zitat Kwee RM. Association between carotid plaque characteristics and cerebral white matter lesions. In: Cardiovascular Image Processing, International Society for Magnetic Resonance in Medicine 19th Annual Meeting. 2011. Available at http://toc.proceedings.com/13329webtoc.pdf. Accessed September 27, 2012. Kwee RM. Association between carotid plaque characteristics and cerebral white matter lesions. In: Cardiovascular Image Processing, International Society for Magnetic Resonance in Medicine 19th Annual Meeting. 2011. Available at http://​toc.​proceedings.​com/​13329webtoc.​pdf. Accessed September 27, 2012.
43.
Zurück zum Zitat Gao H, Long Q, Kumar Das S, Halls J, Graves M, Gillard JH, et al. Study of carotid arterial plaque stress for symptomatic and asymptomatic patients. J Biomech. 2011;44(14):2551–7. Gao H, Long Q, Kumar Das S, Halls J, Graves M, Gillard JH, et al. Study of carotid arterial plaque stress for symptomatic and asymptomatic patients. J Biomech. 2011;44(14):2551–7.
44.
Zurück zum Zitat Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, et al. Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study. Eur J Vasc Endovasc Surg. 2010;40:485–91.PubMedCrossRef Sadat U, Teng Z, Young VE, Walsh SR, Li ZY, Graves MJ, et al. Association between biomechanical structural stresses of atherosclerotic carotid plaques and subsequent ischaemic cerebrovascular events–a longitudinal in vivo magnetic resonance imaging-based finite element study. Eur J Vasc Endovasc Surg. 2010;40:485–91.PubMedCrossRef
45.
Zurück zum Zitat Sadat U, Teng Z, Young VE, Graves MJ, Gaunt ME, Gillard JH. High-resolution magnetic resonance imaging-based biomechanical stress analysis of carotid atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups. Eur J Vasc Endovasc Surg. 2011;41(1):83–90. Sadat U, Teng Z, Young VE, Graves MJ, Gaunt ME, Gillard JH. High-resolution magnetic resonance imaging-based biomechanical stress analysis of carotid atheroma: a comparison of single transient ischaemic attack, recurrent transient ischaemic attacks, non-disabling stroke and asymptomatic patient groups. Eur J Vasc Endovasc Surg. 2011;41(1):83–90.
46.
Zurück zum Zitat Freilinger T, Dimitriadis K, Nikolaou K, Reiser MF, Dichgans M, Saam T. Stroke while squeezing a pimple: traumatic rupture of a vulnerable carotid artery plaque. Neurology. 2011;76(3):305–6. Freilinger T, Dimitriadis K, Nikolaou K, Reiser MF, Dichgans M, Saam T. Stroke while squeezing a pimple: traumatic rupture of a vulnerable carotid artery plaque. Neurology. 2011;76(3):305–6.
47.
Zurück zum Zitat Rubin MF, Rosas SE, Chirinos JA, Townsend RR. Surrogate markers of cardiovascular disease in CKD: what’s under the hood? Am J Kidney Dis. Published by Elsevier Inc. 2011;57(3):488–97. Rubin MF, Rosas SE, Chirinos JA, Townsend RR. Surrogate markers of cardiovascular disease in CKD: what’s under the hood? Am J Kidney Dis. Published by Elsevier Inc. 2011;57(3):488–97.
48.
Zurück zum Zitat Ueda K, Watanabe Y, Katsumata T, Kaneko T, Otori T, Utsumi K, et al. Carotid intima-media thickness and cerebral white matter lesions are more advanced in acute ischemic stroke patients with renal dysfunction. Clin Nephrol. 2011;76(4):290–5. Ueda K, Watanabe Y, Katsumata T, Kaneko T, Otori T, Utsumi K, et al. Carotid intima-media thickness and cerebral white matter lesions are more advanced in acute ischemic stroke patients with renal dysfunction. Clin Nephrol. 2011;76(4):290–5.
49.
Zurück zum Zitat Chou CC, Lien LM, Chen WH, Wu MS, Lin SM, Chiu HC, et al. Adults with late stage 3 chronic kidney disease are at high risk for prevalent silent brain infarction: a population-based study. Stroke. 2011;42(8):2120–5. Chou CC, Lien LM, Chen WH, Wu MS, Lin SM, Chiu HC, et al. Adults with late stage 3 chronic kidney disease are at high risk for prevalent silent brain infarction: a population-based study. Stroke. 2011;42(8):2120–5.
50.
Zurück zum Zitat Teng Z, Degnan AJ, Sadat U, Wang F, Young VE, Graves MJ, et al. Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011;13:64. Teng Z, Degnan AJ, Sadat U, Wang F, Young VE, Graves MJ, et al. Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2011;13:64.
51.
Zurück zum Zitat Falk E, Sillesen H, Muntendam P, Fuster V. The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population. Curr Atheroscler Rep. 2011;13:359–66.PubMedCrossRef Falk E, Sillesen H, Muntendam P, Fuster V. The high-risk plaque initiative: primary prevention of atherothrombotic events in the asymptomatic population. Curr Atheroscler Rep. 2011;13:359–66.PubMedCrossRef
52.
Zurück zum Zitat Yarnykh VL, Terashima M, Hayes CE, Shimakawa A, Takaya N, Nguyen PK, et al. Multicontrast black-blood MRI of carotid arteries: comparison between 1.5 and 3 tesla magnetic field strengths. J Magn Reson Imaging. 2006;23:691–8.PubMedCrossRef Yarnykh VL, Terashima M, Hayes CE, Shimakawa A, Takaya N, Nguyen PK, et al. Multicontrast black-blood MRI of carotid arteries: comparison between 1.5 and 3 tesla magnetic field strengths. J Magn Reson Imaging. 2006;23:691–8.PubMedCrossRef
53.
Zurück zum Zitat Koktzoglou I, Li D. Submillimeter isotropic resolution carotid wall MRI with swallowing compensation: imaging results and semiautomated wall morphometry. J Magn Reson Imaging. 2007;25:815–23.PubMedCrossRef Koktzoglou I, Li D. Submillimeter isotropic resolution carotid wall MRI with swallowing compensation: imaging results and semiautomated wall morphometry. J Magn Reson Imaging. 2007;25:815–23.PubMedCrossRef
Metadaten
Titel
Magnetic Resonance Imaging of Carotid Atherosclerosis and the Risk of Stroke
verfasst von
Navneet Singh
Anna E. Zavodni
Alan R. Moody
Publikationsdatum
01.02.2013
Verlag
Current Science Inc.
Erschienen in
Current Cardiovascular Imaging Reports / Ausgabe 1/2013
Print ISSN: 1941-9066
Elektronische ISSN: 1941-9074
DOI
https://doi.org/10.1007/s12410-012-9178-9

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