The sellar and juxtasellar regions in the paediatric population are complex both anatomically and pathologically, with magnetic resonance imaging (MRI) being the “gold standard” imaging modality due to the high contrast of detail. Assessment requires a detailed understanding of the anatomy, embryology, pathophysiology and normal signal characteristics of the pituitary gland and surrounding structures in order to appropriately characterise abnormalities. This article aims to provide an overview of the imaging characteristics of developmental/congenital and acquired disease processes which affect the sellar and juxtasellar region in the paediatric population.
• The sellar region is anatomically complex and covers a wide pathology spectrum.
• MRI is the key imaging modality to assess sellar and juxtasellar pathology.
• Numerous developmental anomalies may not be discovered until adulthood.
• Knowledge of pathology alerts and guides the clinician towards appropriate management.
Delman BN (2009) Imaging of pediatric pituitary abnormalities. Endocrinol Metab Clin N Am 38:673–698 CrossRef
Dietrich RB, Lis LE, Greensite FS, Pitt D (1995) Normal MR appearance of the pituitary gland in the first 2 years of life. AJNR Am J Neuroradiol 16:1413–1419 PubMed
Fujisawa I, Asato R, Nishimura K et al (1987) Anterior and posterior lobes of the pituitary gland: assessment by 1.5 T MR imaging. J Comput Assist Tomogr 11:214–220
Nishimura K, Fujisawa I, Togashi K et al (1986) Posterior lobe of the pituitary: identification by lack of chemical shift artifact in MR imaging. J Comput Assist Tomogr 10:899–902
Fujisawa I, Asato R, Kawata M et al (1989) Hyperintense signal of the posterior pituitary on T1-weighted MR images: an experimental study. J Comput Assist Tomogr 13:371–377
Takano K, Utsunomiya H, Ono H et al (1999) Normal development of the pituitary gland: assessment with three-dimensional MR volumetry. AJNR Am J Neuroradiol 20:312–315 PubMed
Hamilton J, Blaser S, Daneman D (1998) MR imaging in idiopathic growth hormone deficiency. AJNR Am J Neuroradiol 19:1609–1615 PubMed
Kelly WM, Kucharczyk W, Kucharczyk J et al (1988) Posterior pituitary ectopia: An MR feature of pituitary dwarfism. Am J Neuroradiol 9:453–460 PubMed
Pellegrini-Bouiller I, Bélicar P, Barlier A et al (1996) A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone deficiency. J Clin Endicrinol Metab 81:2790–2796
Di Iorgi N, Iorgi ND, Allegri AEM et al (2012) The use of neuroimaging for assessing disorders of pituitary development. Clin Endocrinol (Oxf) 76:161–176 CrossRef
Boyko OB, Curnes JT, Oakes WJ, Burger PC Hamartomas of the tuber cinereum: CT, MR, and pathologic findings. AJNR Am J Neuroradiol 12:309–314
Saleem SN, Said A-HM, Lee DH (2007) Lesions of the hypothalamus: MR imaging diagnostic features. Radiographics 27:1087–1108
Freeman JL, Coleman LT, Wellard RM et al (2004) MR imaging and spectroscopic study of epileptogenic hypothalamic hamartomas: analysis of 72 cases. AJNR Am J Neuroradiol 25:450–462 PubMed
Takanashi JI, Tada H, Barkovich AJ et al (2005) Pituitary cysts in childhood evaluated by MR imaging. Am J Neuroradiol 26:2144–2147 PubMed
Byun WM, Kim OL, Kim DS (2000) MR imaging findings of Rathke’s cleft cysts: significance of intracystic nodules. AJNR Am J Neuroradiol 21:485–488 PubMed
Brassier G, Morandi X, Tayiar E et al (1999) Rathke’s cleft cysts: surgical-MRI correlation in 16 symptomatic cases. J Neuroradiol 26:162–171 PubMed
Gelabert-González M (1998) Intracranial epidermoid and dermoid cysts. Rev Neurol 27:777–782 PubMed
Venkatesh SK, Phadke RV, Trivedi P, Bannerji D (2002) Asymptomatic spontaneous rupture of suprasellar dermoid cyst: a case report. Neurol India 50:480–483 PubMed
Güzel A, Trippel M, Ostertage CB (2007) Suprasellar arachnoid cyst: a 20-year follow-up after stereotactic internal drainage: case report and review of the literature. Turk Neurosurg 17:211–218 PubMed
Cacciari E, Zucchini S, Ambrosetto P et al (1994) Empty sella in children and adolescents with possible hypothalamic-pituitary disorders. J Clin Endocrinol Metab 78:767–771 PubMed
Jinkins JR, Gupta R, Chang KH, Rodriguez-Carbajal J (1995) MR imaging of central nervous system tuberculosis. Radiol Clin N Am 33:771–786 PubMed
Cotterill SJ, Ahrens S, Paulussen M et al (2000) Prognostic factors in Ewing’s tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group. J Clin Oncol 18:3108–3114 PubMed
Broich G, Pagliari A, Ottaviani F (1997) Esthesioneuroblastoma: a general review of the cases published since the discovery of the tumour in 1924. Anticancer Res 17:2683–2706 PubMed
(1996) A multicentre retrospective survey of Langerhans’ cell histiocytosis: 348 cases observed between 1983 and 1993. The French Langerhans' Cell Histiocytosis Study Group. Arch Dis Child 75:17–24
Prayer D, Grois N, Prosch H et al (2004) MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol 25:880–891 PubMed
- Magnetic resonance imaging of sellar and juxtasellar abnormalities in the paediatric population: an imaging review
- Springer Berlin Heidelberg
Neu im Fachgebiet Radiologie
Meistgelesene Bücher aus der Radiologie
Mail Icon II