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European Radiology

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19.12.2018 | Magnetic Resonance

Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis

Erschienen in: European Radiology | Ausgabe 6/2019

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Abstract

Objectives

Assessing a posterior fossa tumour in an adult can be challenging. Metastasis, haemangioblastoma, ependymal tumours, and medulloblastoma are the most common diagnostic possibilities. Our aim was to evaluate the contribution of magnetic resonance spectroscopy (MRS) in the diagnosis of these entities.

Methods

We retrospectively evaluated 56 consecutive patients with a posterior fossa tumour and histological diagnosis of ependymal tumour, medulloblastoma, haemangioblastoma, and metastasis in which good-quality spectra at short (TE 30 ms) or/and intermediate (TE, 136 ms) TE were available. Spectra were compared using the Mann-Whitney U non-parametric test in order to select the spectral datapoints and the intensity ratios that showed significant differences between groups of lesions. Performance of these datapoints and their ratios were assessed with ROC curves.

Results

The most characteristic signatures on spectroscopy were high choline (Cho) in medulloblastoma (p < 0.001), high myoinositol (mIns) in ependymal tumours (p < 0.05), and high lipids (LIP) in haemangioblastoma (p < 0.01) and metastasis (p < 0.01). Selected ratios between normalised intensity signals of resonances provided accuracy values between 79 and 95% for pairwise comparisons. Intensity ratio NI_{3.21ppm/3.55ppm} provided satisfactory discrimination between medulloblastoma and ependymal tumours (accuracy, 92%), ratio NI_{2.11ppm/1.10ppm} discriminated ependymal tumours from haemangioblastoma (accuracy, 94%), ratio NI_{3.21ppm/1.13ppm} discriminated haemangioblastoma from medulloblastoma (accuracy, 95%), and ratio NI_{1.28ppm/2.02pmm} discriminated haemangioblastoma from metastasis (accuracy, 83%).

Conclusions

MRS may improve the non-invasive diagnosis of posterior fossa tumours in adults.

Key Points

• High choline suggests a medulloblastoma in a posterior fossa tumour.

• High myoinositol suggests an ependymal lesion in a posterior fossa tumour.

• High lipids suggest a metastasis or a haemangioblastoma in a posterior fossa tumour.

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Titel: Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis
Publikationsdatum: 19.12.2018
Erschienen in: European Radiology / Ausgabe 6/2019
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-018-5879-z

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Magnetic resonance spectroscopy in posterior fossa tumours: the tumour spectroscopic signature may improve discrimination in adults among haemangioblastoma, ependymal tumours, medulloblastoma, and metastasis

Abstract

Objectives

Methods

Results

Conclusions

Key Points

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Abstract

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Methods

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Conclusions

Key Points

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