Magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle might be a sensitive biomarker for multiple system atrophy
- 25.11.2020
- Magnetic Resonance
Erschienen in:
- Verfasst von
- Atsuhiko Sugiyama
- Hajime Yokota
- Shigeki Hirano
- Graham Cooper
- Hiroki Mukai
- Kyosuke Koide
- Jiaqi Wang
- Shoichi Ito
- Carsten Finke
- Alexander U Brandt
- Friedemann Paul
- Satoshi Kuwabara
- Erschienen in
- European Radiology | Ausgabe 6/2021
Abstract
Objective
We aimed to investigate the use of a myelin-sensitive MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, for detecting early changes in the middle cerebellar peduncle (MCP) in cerebellar subtype multiple system atrophy (MSA-C) patients.
Methods
We included 28 MSA-C patients, including a subset of 17 MSA-C patients within 2 years of disease onset (early MSA-C), and 28 matched healthy controls. T1w and T2w scans were acquired using a 3-T MR system. The sT1w/T2w ratio in MCP was analyzed using SPM12 by utilizing a region-of-interest approach in normalized space. The diagnostic performance of the MCP sT1w/T2w ratio in discriminating MSA-C and the subgroup of early MSA-C from the matched controls was assessed. Correlation analyses were performed to evaluate the relationship between the MCP sT1w/T2w ratio and other clinical parameters including the International Cooperative Ataxia Scale (ICARS) score for quantifying cerebellar ataxia.
Results
Compared to controls, the sT1w/T2w ratio in the MCP was markedly lower in all (p < 0.001) MSA-C patients and 17 early (p < 0.001) MSA-C patients. The MCP sT1w/T2w ratio had high sensitivity (96%) and specificity (100%) to distinguish MSA-C from controls (area under the curve = 0.99), even for the early MSA-C group (area under the curve = 0.99; sensitivity = 94%, specificity = 100%). The MCP sT1w/T2w ratio correlated with the ICARS score in early MSA-C.
Conclusions
The sT1w/T2w ratio can detect MSA-C-related changes in the MCP, even in the early stages of the disorder, and could be a sensitive biomarker for MSA-C.
Key Points
• The sT1w/T2w ratio can detect MSA-C-related changes in the middle cerebellar peduncle, even in the early stages of the disorder.
• The middle cerebellar peduncle sT1w/T2w ratio correlated with a cerebellar ataxia score in early MSA-C patients.
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- Titel
- Magnetic resonance T1w/T2w ratio in the middle cerebellar peduncle might be a sensitive biomarker for multiple system atrophy
- Verfasst von
-
Atsuhiko Sugiyama
Hajime Yokota
Shigeki Hirano
Graham Cooper
Hiroki Mukai
Kyosuke Koide
Jiaqi Wang
Shoichi Ito
Carsten Finke
Alexander U Brandt
Friedemann Paul
Satoshi Kuwabara
- Publikationsdatum
- 25.11.2020
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
European Radiology / Ausgabe 6/2021
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084 - DOI
- https://doi.org/10.1007/s00330-020-07521-1
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