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08.02.2020 | Research article

Main gut bacterial composition differs between patients with type 1 and type 2 diabetes and non-diabetic adults

Zeitschrift:
Journal of Diabetes & Metabolic Disorders
Autoren:
Hanieh-Sadat Ejtahed, Zahra Hoseini-Tavassol, Shohre Khatami, Mehrangiz Zangeneh, Ava Behrouzi, Sara Ahmadi Badi, Arfa Moshiri, Shirin Hasani-Ranjbar, Ahmad-Reza Soroush, Farzam Vaziri, Abolfazl Fateh, Mostafa Ghanei, Saeid Bouzari, Shahin Najar-Peerayeh, Seyed Davar Siadat, Bagher Larijani
Wichtige Hinweise
Hanieh-Sadat Ejtahed and Zahra Hoseini-Tavassol contributed equally to this work.

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Abstract

Background

Regarding the role of gut microbial dysbiosis in hyperglycemia, we aimed to compare the main gut bacterial composition among type 1 and type 2 diabetic patients and healthy non-diabetic adults.

Methods

A total of 110 adult subjects (49 patients diagnosed with type 2 diabetes, 21 patients diagnosed with type 1 diabetes and 40 healthy persons) were included in this case-control study. The intestinal microbiota composition was investigated by quantitative real-time polymerase chain reaction (qPCR) method targeting bacterial 16S rRNA gene. Comparison between three groups was done using one-way analysis of variance.

Results

The participants’ mean age in the type 1 diabetes, type 2 diabetes and control groups was 35.4, 57.2 and 38.0 years, respectively. Higher level of Escherichia, Prevotella and Lactobacillus was observed in both type 1 and type 2 diabetic patients compared with the healthy group (P ˂0.001). In contrast, bacterial load of Bifidobacterium, Roseburia and Bacteroides was higher in healthy control group (P < 0.05). Faecalibacterium was significantly lower in type 1 diabetic patients compared with the other two groups (P ˂0.001). No significant difference was found in Akkermansia level among three groups.

Conclusions

Gut microbial alterations have been observed among patients suffering from type 1 and type 2 diabetes mellitus and healthy control adults. Butyrate producing genera including Roseburia and Faecalibacterium decreased while Escherichia, Prevotella and Lactobacillus increased in diabetic patients compared to healthy subjects. Modulating approaches of gut microbiota composition could be helpful in diabetes management.

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