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01.12.2012 | Opinion | Ausgabe 1/2012 Open Access

Malaria Journal 1/2012

Malaria in infants aged less than six months - is it an area of unmet medical need?

Zeitschrift:
Malaria Journal > Ausgabe 1/2012
Autoren:
Umberto D’Alessandro, David Ubben, Kamal Hamed, Serign Jawo Ceesay, Joseph Okebe, Makie Taal, Eugene Kaman Lama, Moussa Keita, Lamine Koivogui, Alain Nahum, Kalifa Bojang, Aja Adam Jagne Sonko, Honorat Francis Lalya, Bernard Brabin
Wichtige Hinweise

Competing interests

UD has been invited as speaker at symposia organized by Sigma Tau and Novartis Pharma, and has received a research grant from Sigma Tau. KH is an employee of Novartis Pharmaceuticals Corporation, East Hanover, NJ, USA. This declaration is made in the interest of full disclosure and not because the author considers this to be a competing interest. The other authors have no competing interest to declare.

Authors’ contributions

All authors met International Committee of Medical Journal Editors criteria for authorship. All authors contributed to the development of the outline, revised the manuscript critically, and read and approved the final manuscript.

Abstract

Despite the protection provided by several factors, including maternal antibodies, the burden of malaria in young infants may be higher than previously thought. Infants with congenital or neonatal malaria may have a different clinical presentation than older children, and diagnosis may be confused with other neonatal diseases due to an overlap of clinical manifestations. In addition, there is little information on the use of artemisinin-based combination therapy in young infants. There is the need for a more accurate estimate of the parasite prevalence and the incidence of clinical malaria in infants under 6 months old, as well as a better characterization of risk factors, pharmacokinetic profiles, safety and efficacy of currently available anti-malarial treatments, in order to develop evidence-based treatment guidelines for this population.
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