The authors declare that they have no conflicts of interest.
GS conceived and prepared the manuscript, and TK, AK, PT, SM, WM, and CS contributed to developing the concepts presented in this paper and provided valuable insight during the revision and editing stages. All authors read and approved the final manuscript.
The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.
malERA Consultative Group on Diagnoses and Diagnostics: A research agenda for malaria eradication: diagnoses and diagnostics. PLoS Med. 2011, 8: e1000396- CrossRef
Harris I, Sharrock WW, Bain LM, Gray KA, Bobogare A, Boaz L, Lilley K, Krause D, Vallely A, Johnson ML, Gatton ML, Shanks GD, Cheng Q: A large proportion of asymptomatic Plasmodium infections with low and sub-microscopic parasite densities in the low transmission setting of Temotu Province, Solomon Islands: challenges for malaria diagnostics in an elimination setting. Malar J. 2010, 9: 254-10.1186/1475-2875-9-254. PubMedCentralCrossRefPubMed
Baliraine FN, Afrane YA, Amenya DA, Bonizzoni M, Menge DM, Zhou G, Zhong D, Vardo-Zalik AM, Githeko A, Yan G: High prevalence of asymptomatic Plasmodium falciparum infections in a highland area of western Kenya: A cohort study. J Infect Dis. 2009, 200: 66-74. 10.1086/599317. PubMedCentralCrossRefPubMed
Sutcliffe CG, Kobayashi T, Hamapumbu H, Shields T, Kamanga A, Mharakurwa S, Thuma PE, Glass G, Moss WJ: Changing individual-level risk factors for malaria with declining transmission in southern Zambia: a cross-sectional study. Malar J. 2011, 10: 324-10.1186/1475-2875-10-324. PubMedCentralCrossRefPubMed
Stresman GH, Kamanga A, Moono P, Hamapumbu H, Mharakurwa S, Kobayashi T, Moss WJ, Shiff C: A method of active case detection to target reservoirs of asymptomatic malaria and gametocyte carriers in a rural area in Southern Province. Zambia. Malar J. 2010, 9: 265- PubMed
Sutcliffe CG, Kobayashi T, Hamapumbu H, Shields T, Mharakurwa S, Thuma PE, Louis TA, Glass G, Moss WJ: Reduced risk of malaria parasitemia following household screening and treatment: A cross-sectional and longitudinal cohort study. PLoS One. 2012, 7: e31396-10.1371/journal.pone.0031396. PubMedCentralCrossRefPubMed
Poschl B, Waneesorn J, Thekisoe O, Chutipongvivate S, Panagiotis K: Comparative diagnosis of malaria infections by microscopy, nested PCR, and LAMP in Northern Thailand. AmJTrop Med Hyg. 2010, 83: 56-60. CrossRef
Schachterle SE, Ntove G, Levens JP, Clemens EG, Shi L, Raj A, Munoz B, Reller ME, West S, Dumler JS, Sullivan D: Prevalence and density-related concordance of three diagnostic tests for malaria in a region of Tanzania with hypoendemic malaria. J Clin Microbiol. 2011, 49: 3885-3891. 10.1128/JCM.01157-11. PubMedCentralCrossRefPubMed
Mahajan B, Zheng H, Pham PT, Sedegah MY, Majam VF, Akolkar N, Rios M, Ankrah I, Madjitey P, Amoah G, Addison E, Quakyi IA, Kumar S: Polymerase chain reaction-based tests for pan-species and species-specific detection of human Plasmodium parasites. Transfusion. 2012, 10.1111/j.1537-2995.2011.03541.x.
Shekalaghe SA, Drakeley C, van den Bosch S, ter Braak R, van den Bijllaardt W, Mwanziva C, Semvua S, Masokoto A, Mosha F, Teelen K, Hermsen R, Okell L, Gosling R, Sauerwein R, Bousema T: A cluster-randomized trial of mass drug administration with a gametocytocidal drug combination to interrupt malaria transmission in a low endemic area in Tanzania. Malar J. 2011, 10: 247-10.1186/1475-2875-10-247. PubMedCentralCrossRefPubMed
WHO: Global malaria control and elimination: report of a technical review. 2008, World Health Organization
- Malaria research challenges in low prevalence settings
Philip E Thuma
William J Moss
- BioMed Central
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