The authors declare that they have no conflicts of interest.
GS conceived and prepared the manuscript, and TK, AK, PT, SM, WM, and CS contributed to developing the concepts presented in this paper and provided valuable insight during the revision and editing stages. All authors read and approved the final manuscript.
The prevalence of malaria has reduced significantly in some areas over the past decade. These reductions have made local elimination possible and the research agenda has shifted to this new priority. However, there are critical issues that arise when studying malaria in low transmission settings, particularly identifying asymptomatic infections, accurate detection of individuals with microparasitaemic infections, and achieving a sufficient sample size to have an adequately powered study. These challenges could adversely impact the study of malaria elimination if they remain unanswered.
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- Malaria research challenges in low prevalence settings
Philip E Thuma
William J Moss
- BioMed Central
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