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01.12.2017 | Case report | Ausgabe 1/2017 Open Access

BMC Cancer 1/2017

Malignant acrospiroma: a case report in the era of next generation sequencing

Zeitschrift:
BMC Cancer > Ausgabe 1/2017
Autoren:
Maria Diab, Ali Gabali, Muaiad Kittaneh

Abstract

Background

Malignant acrospiroma is a rare tumor of the eccrine sweat glands accounting for around 6% of all malignant eccrine tumors. Typically, it presents as large ulcerated nodules, and diagnosis can be challenging as it has great overlap with its benign counterpart.

Case presentation

We herein report a case of acral malignant acrospiroma, initially treated with surgical excision and adjuvant radiotherapy. After metastatic disease was confirmed, subject received multiple lines of chemo- as well as targeted therapy. Genomic testing was also done using next generation sequencing.

Conclusion

To the best of our knowledge, this is the first case of acral malignant acrospiroma with reported next generation sequencing results.
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