Skip to main content

01.12.2008 | Case report | Ausgabe 1/2008 Open Access

Journal of Medical Case Reports 1/2008

Malignant peritoneal mesothelioma as a rare cause of ascites: a case report

Journal of Medical Case Reports > Ausgabe 1/2008
Iftikhar Ahmed, Anastasios Koulaouzidis, Javaid Iqbal, Wong C Tan
Wichtige Hinweise

Electronic supplementary material

The online version of this article (doi:10.​1186/​1752-1947-2-121) contains supplementary material, which is available to authorized users.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

IA was involved in writing the case, the literature review and obtaining patient consent. WCT was involved in proof reading and final refinement. AK was involved in proof reading and final refinement. JI was involved in the final revision and in making modifications following suggestions by the reviewers.
acid-fast bacilli
computed tomography
full blood count
heated intraoperative intraperitoneal chemotherapy
liver function test
serum ascites-albumen gradient.


Malignant mesothelioma of the peritoneum is rare but rapidly fatal malignancy. The median survival rang from 5 to 12 months, mainly because of lack of effective treatment. The incidence is approximately one per 1,000,000; approximately one fifth to one third of all mesotheliomas are peritoneal. Half of reported cases have a history of asbestos exposure. The diagnosis of peritoneal mesothelioma is often delayed, in part because of the usually long latent period (peaking at 40–45 years from the time of initial exposure to asbestos) and because the common presenting symptoms of weight loss, usually with a full abdomen, malaise, and abdominal discomfort, are mild and nonspecific. Because of its unusual nature, the disease has not been clearly defined in terms of its natural history, diagnosis, or management. Treatment options with intravenous chemotherapy are far from satisfactory. However, because malignant peritoneal mesothelioma usually remains confined to the peritoneal cavity for most of its natural history, regional chemotherapy is an attractive option.

Case presentation

A 75-year-old woman was admitted with a five-week history of progressive dyspnoea, ascites, leg edema and lethargy. She had a previous history of pulmonary tuberculosis 50 years earlier and hypertension which was well controlled with atenolol. She had never smoked and had no known previous exposure to asbestos. She had a family history of lung and large bowel cancer but no history of mesothelioma.
Clinical examination revealed bilateral pedal pitting edema but no signs of chronic liver disease. She had moderate ascites but normal cardiovascular and respiratory system examinations. Blood investigations including full blood count (FBC), urea and electrolytes, liver function tests (LFTs), inflammatory markers, hepatitis, viral and autoimmune screens were all normal. Initial ultrasound scan and computed tomography (CT) scan of the abdomen and pelvis were unable to demonstrate any significant abdominal pathology other than ascites. A diagnostic ascitic tap yielded transudate with a serum ascites-albumin gradient (SA-AG) of 32. Ascitic fluid culture and culture for acid-fast bacilli (AFB) were also negative. The ascites recurred despite multiple drainages. She had a repeat CT scan which showed extensive peritoneal nodularity and omental cake along with massive ascites. A diagnostic laparoscopy with omental biopsy was performed. It showed infiltration of the omentum with a poorly differentiated malignant tumor consisting of sheaths of cells with fairly uniform nuclei containing prominent nucleoli (Figure 1).
A barium enema and flexible sigmoidoscopy showed no bowel pathology apart from mild diverticular disease with pedunculated polyps which were found to be benign on histology. Immunochemical staining of the biopsy showed features consistent with diffuse mesothelioma. She was referred to the oncology department after a multidisciplinary meeting discussion and chemotherapy was planned with cisplatin and pemetrexed. She responded well initially and the ascites resolved with improved general wellbeing, but the treatment was later stopped when she developed side effects in the form of recurrent vomiting and general malaise. Currently she is having palliative treatment and is under regular oncology follow up.


Mesothelioma is a neoplasm originating from the mesothelial surface lining cells of serous cavities. Most often, mesotheliomas involve the serosal membranes of the pleura and peritoneum. Sometimes mesothelial proliferations are identified in other locations. On rare occasions, it has been reported in the tunica vaginalis of the testis [ 1, 2]. Among all cases of mesothelioma, about 80% are pleural in origin. A causal relationship between asbestos exposure and pleural, peritoneal and pericardial malignant mesotheliomas has been suggested, the risk of cancer being correlated with cumulative exposure. There is some evidence that simian virus 40 may have some role in co-carcinogenesis [ 1, 3].
Symptomatology is insidious and poses difficult problems in diagnosis and treatment. People with peritoneal mesothelioma generally present with one of two types of symptoms and signs: those with abdominal pain, usually localized and related to a dominant tumor mass with little or no ascites, and those without abdominal pain, but with ascites and abdominal distention [ 4].
Ultrasonography and CT scan of the abdomen can provide important information during the diagnostic process. Nevertheless, a definite diagnosis can only be established by laparoscopy or open surgery with biopsy to obtain histological examination along with immunocytochemical procedures. Laparoscopy is an important tool in the diagnosis of some unusual causes of ascites, such as primary mesothelioma, which are usually overlooked by other diagnostic modalities, such as ultrasound, CT and cytology of the ascitic fluid. However, laparoscopy can greatly complicate management by facilitating tumor dissemination to port sites [ 5].
Pathologically, a positive immunostain for calretinin has markedly increased the accuracy of diagnosis [ 1]. Prognosis, as determined by clinical presentation, the completeness of cytoreduction and gender, given that women survive longer than men with this condition, appears to be improved by the use of intraperitoneal chemotherapy.
Over the past decade, the management of these patients has evolved similarly to ovarian cancer treatment and now involves cytoreductive surgery, heated intraoperative intraperitoneal chemotherapy (HIIC) with cisplatin and doxorubicin, and early postoperative intraperitoneal paclitaxel. These perioperative treatments are followed by adjuvant intraperitoneal paclitaxel and second-look cytoreduction. This multimodality treatment approach with cytoreductive surgery and intraperitoneal chemotherapy has resulted in a median survival of 50 to 60 months [ 1, 4].


This case denotes the importance of considering the differential diagnosis of common clinical problems. Peritoneal mesothelioma, although uncommon, should be considered in people presenting with ascites, in particular in those where the initial diagnosis is not clear. A history of asbestos exposure may not be present and radiological investigations may miss the diagnosis so thorough clinical assessment and a broad-thinking approach is important.


Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Competing interests

The authors declare that they have no competing interests.

Authors' contributions

IA was involved in writing the case, the literature review and obtaining patient consent. WCT was involved in proof reading and final refinement. AK was involved in proof reading and final refinement. JI was involved in the final revision and in making modifications following suggestions by the reviewers.

Unsere Produktempfehlungen

e.Med Interdisziplinär


Für Ihren Erfolg in Klinik und Praxis - Die beste Hilfe in Ihrem Arbeitsalltag als Mediziner

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf

Alle e.Med Abos bis 30. April 2021 zum halben Preis!

Jetzt e.Med zum Sonderpreis bestellen!

e.Med Allgemeinmedizin


Mit e.Med Allgemeinmedizin erhalten Sie Zugang zu allen CME-Fortbildungen und Premium-Inhalten der allgemeinmedizinischen Zeitschriften, inklusive einer gedruckten Allgemeinmedizin-Zeitschrift Ihrer Wahl.

Über diesen Artikel

Weitere Artikel der Ausgabe 1/2008

Journal of Medical Case Reports 1/2008 Zur Ausgabe