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Erschienen in: Die Dermatologie 7/2021

16.06.2021 | Maligne Tumoren der Haut | CME

Management von malignen Adnextumoren der Haut

verfasst von: Pia Nagel, Verena Müller, Prof. Dr. Jochen Utikal

Erschienen in: Die Dermatologie | Ausgabe 7/2021

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Zusammenfassung

Die malignen Adnextumoren der Haut sind eine heterogene Gruppe seltener Malignome mit ekkriner, apokriner, sebozytärer und follikulärer Differenzierung. Wichtige Handlungsempfehlungen für das allgemeine Management dieser Tumorerkrankungen werden vorgestellt. Außerdem werden spezifische evidenzbasierte Erkenntnisse bezüglich der Diagnostik, Therapie und Nachsorge von Porokarzinomen, Talgdrüsenkarzinomen sowie mikrozystischen Adnexkarzinomen erläutert.
Literatur
1.
Zurück zum Zitat Weltgesundheitsorganisation (2018) WHO classification of skin tumours. International Agency for Research on Cancer, Lyon Weltgesundheitsorganisation (2018) WHO classification of skin tumours. International Agency for Research on Cancer, Lyon
2.
Zurück zum Zitat Stam H, Lohuis PJ, Zupan-Kajcovski B et al (2013) Increasing incidence and survival of a rare skin cancer in the Netherlands. A population-based study of 2,220 cases of skin adnexal carcinoma. J Surg Oncol 107:822–827 PubMed Stam H, Lohuis PJ, Zupan-Kajcovski B et al (2013) Increasing incidence and survival of a rare skin cancer in the Netherlands. A population-based study of 2,220 cases of skin adnexal carcinoma. J Surg Oncol 107:822–827 PubMed
3.
Zurück zum Zitat Tanese K, Nakamura Y, Hirai I et al (2019) Updates on the systemic treatment of advanced non-melanoma skin cancer. Front Med 6:160 Tanese K, Nakamura Y, Hirai I et al (2019) Updates on the systemic treatment of advanced non-melanoma skin cancer. Front Med 6:160
4.
Zurück zum Zitat Jandali DB, Ganti A, Al-Khudari S et al (2019) Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers. Am J Otolaryngol 40:110–114 PubMed Jandali DB, Ganti A, Al-Khudari S et al (2019) Prognostic factors and survival outcomes for head and neck cutaneous adnexal cancers. Am J Otolaryngol 40:110–114 PubMed
5.
Zurück zum Zitat Waqas O, Faisal M, Haider I et al (2017) Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series. J Med Case Rep 11:67 PubMedPubMedCentral Waqas O, Faisal M, Haider I et al (2017) Retrospective study of rare cutaneous malignant adnexal tumors of the head and neck in a tertiary care cancer hospital: a case series. J Med Case Rep 11:67 PubMedPubMedCentral
6.
Zurück zum Zitat Abbate M, Zeitouni NC, Seyler M et al (2003) Clinical course, risk factors, and treatment of microcystic adnexal carcinoma: a short series report. Dermatol Surg 29:1035–1038 PubMed Abbate M, Zeitouni NC, Seyler M et al (2003) Clinical course, risk factors, and treatment of microcystic adnexal carcinoma: a short series report. Dermatol Surg 29:1035–1038 PubMed
7.
Zurück zum Zitat Blake PW, Bradford PT, Devesa SS et al (2010) Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol 146:625–632 PubMed Blake PW, Bradford PT, Devesa SS et al (2010) Cutaneous appendageal carcinoma incidence and survival patterns in the United States: a population-based study. Arch Dermatol 146:625–632 PubMed
8.
Zurück zum Zitat De Giorgi V, Salvati L, Barchielli A et al (2019) The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. Br J Dermatol 180:565–573 PubMed De Giorgi V, Salvati L, Barchielli A et al (2019) The burden of cutaneous adnexal carcinomas and the risk of associated squamous cell carcinoma: a population-based study. Br J Dermatol 180:565–573 PubMed
9.
Zurück zum Zitat Harwood CA, Mcgregor JM, Swale VJ et al (2003) High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients. J Am Acad Dermatol 48:401–408 PubMed Harwood CA, Mcgregor JM, Swale VJ et al (2003) High frequency and diversity of cutaneous appendageal tumors in organ transplant recipients. J Am Acad Dermatol 48:401–408 PubMed
10.
Zurück zum Zitat Lanoy E, Dores GM, Madeleine MM et al (2009) Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 23:385–393 PubMed Lanoy E, Dores GM, Madeleine MM et al (2009) Epidemiology of nonkeratinocytic skin cancers among persons with AIDS in the United States. AIDS 23:385–393 PubMed
11.
Zurück zum Zitat Fueston JC, Gloster HM, Mutasim DF (2006) Primary cutaneous adenoid cystic carcinoma: a case report and literature review. Cutis 77:157–160 PubMed Fueston JC, Gloster HM, Mutasim DF (2006) Primary cutaneous adenoid cystic carcinoma: a case report and literature review. Cutis 77:157–160 PubMed
12.
Zurück zum Zitat Rismiller K, Knackstedt TJ (2018) Aggressive digital papillary adenocarcinoma: population-based analysis of incidence, demographics, treatment, and outcomes. Dermatol Surg 44:911–917 PubMed Rismiller K, Knackstedt TJ (2018) Aggressive digital papillary adenocarcinoma: population-based analysis of incidence, demographics, treatment, and outcomes. Dermatol Surg 44:911–917 PubMed
13.
Zurück zum Zitat Owen JL, Kibbi N, Worley B et al (2019) Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol 20:e699–e714 PubMed Owen JL, Kibbi N, Worley B et al (2019) Sebaceous carcinoma: evidence-based clinical practice guidelines. Lancet Oncol 20:e699–e714 PubMed
15.
Zurück zum Zitat Alsaad KO, Obaidat NA, Ghazarian D (2007) Skin adnexal neoplasms-—part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol 60:129–144 PubMed Alsaad KO, Obaidat NA, Ghazarian D (2007) Skin adnexal neoplasms-—part 1: an approach to tumours of the pilosebaceous unit. J Clin Pathol 60:129–144 PubMed
16.
Zurück zum Zitat Obaidat NA, Alsaad KO, Ghazarian D (2007) Skin adnexal neoplasms—part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol 60:145–159 PubMed Obaidat NA, Alsaad KO, Ghazarian D (2007) Skin adnexal neoplasms—part 2: an approach to tumours of cutaneous sweat glands. J Clin Pathol 60:145–159 PubMed
18.
Zurück zum Zitat Wittekind C (2020) TNM – Klassifikation maligner Tumoren. Wiley-VCH, Weinheim Wittekind C (2020) TNM – Klassifikation maligner Tumoren. Wiley-VCH, Weinheim
19.
Zurück zum Zitat Martinez SR, Barr KL, Canter RJ (2011) Rare tumors through the looking glass: an examination of malignant cutaneous adnexal tumors. Arch Dermatol 147:1058–1062 PubMed Martinez SR, Barr KL, Canter RJ (2011) Rare tumors through the looking glass: an examination of malignant cutaneous adnexal tumors. Arch Dermatol 147:1058–1062 PubMed
20.
Zurück zum Zitat Bernárdez C, Requena L (2018) Treatment of malignant cutaneous Adnexal neoplasms. Actas Dermosifiliogr 109:6–23 PubMed Bernárdez C, Requena L (2018) Treatment of malignant cutaneous Adnexal neoplasms. Actas Dermosifiliogr 109:6–23 PubMed
21.
Zurück zum Zitat Belin E, Ezzedine K, Stanislas S et al (2011) Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. Br J Dermatol 165:985–989 PubMed Belin E, Ezzedine K, Stanislas S et al (2011) Factors in the surgical management of primary eccrine porocarcinoma: prognostic histological factors can guide the surgical procedure. Br J Dermatol 165:985–989 PubMed
22.
Zurück zum Zitat Hardisson D, Linares MD, Cuevas-Santos J et al (2001) Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature. Am J Dermatopathol 23:394–401 PubMed Hardisson D, Linares MD, Cuevas-Santos J et al (2001) Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature. Am J Dermatopathol 23:394–401 PubMed
23.
Zurück zum Zitat Lazar AJ, Calonje E, Grayson W et al (2005) Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol 32:148–157 PubMed Lazar AJ, Calonje E, Grayson W et al (2005) Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol 32:148–157 PubMed
24.
Zurück zum Zitat Kyriazanos ID, Stamos NP, Miliadis L et al (2011) Extra-mammary Paget’s disease of the perianal region: a review of the literature emphasizing the operative management technique. Surg Oncol 20:e61–e71 PubMed Kyriazanos ID, Stamos NP, Miliadis L et al (2011) Extra-mammary Paget’s disease of the perianal region: a review of the literature emphasizing the operative management technique. Surg Oncol 20:e61–e71 PubMed
25.
Zurück zum Zitat Chung PH, Leong JY, Voelzke BB (2019) Surgical experience with genital and perineal extramammary Paget’s disease. Urology 128:90–95 PubMed Chung PH, Leong JY, Voelzke BB (2019) Surgical experience with genital and perineal extramammary Paget’s disease. Urology 128:90–95 PubMed
26.
Zurück zum Zitat Wollina U, Goldman A, Bieneck A et al (2018) Surgical treatment for extramammary Paget’s disease. Curr Treat Options Oncol 19:27 PubMed Wollina U, Goldman A, Bieneck A et al (2018) Surgical treatment for extramammary Paget’s disease. Curr Treat Options Oncol 19:27 PubMed
27.
Zurück zum Zitat Dokic Y, Nguyen QL, Orengo I (2020) Mohs micrographic surgery: a treatment method for many non-melanocytic skin cancers. Dermatol Online J 26(4):13030/qt8zr4f9n4 Dokic Y, Nguyen QL, Orengo I (2020) Mohs micrographic surgery: a treatment method for many non-melanocytic skin cancers. Dermatol Online J 26(4):13030/qt8zr4f9n4
28.
Zurück zum Zitat Wang LS, Handorf EA, Wu H et al (2017) Surgery and adjuvant radiation for high-risk skin Adnexal carcinoma of the head and neck. Am J Clin Oncol 40:429–432 PubMedPubMedCentral Wang LS, Handorf EA, Wu H et al (2017) Surgery and adjuvant radiation for high-risk skin Adnexal carcinoma of the head and neck. Am J Clin Oncol 40:429–432 PubMedPubMedCentral
30.
Zurück zum Zitat Nagasawa T, Hirata A, Niiyama S et al (2019) Successful treatment of porocarcinoma with maxacalcitol and imiquimod. Dermatol Ther 32:e12830 PubMed Nagasawa T, Hirata A, Niiyama S et al (2019) Successful treatment of porocarcinoma with maxacalcitol and imiquimod. Dermatol Ther 32:e12830 PubMed
31.
Zurück zum Zitat Jo JH, Ko HC, Jang HS et al (2005) Infiltrative trichilemmal carcinoma treated with 5 % imiquimod cream. Dermatol Surg 31:973–976 PubMed Jo JH, Ko HC, Jang HS et al (2005) Infiltrative trichilemmal carcinoma treated with 5 % imiquimod cream. Dermatol Surg 31:973–976 PubMed
32.
Zurück zum Zitat Borgognoni L, Pescitelli L, Gerlini G et al (2020) Efficacy of electrochemotherapy in the treatment of cutaneous melanoma metastases and rare non-melanoma skin cancer. Anticancer Res 40:6485–6492 PubMed Borgognoni L, Pescitelli L, Gerlini G et al (2020) Efficacy of electrochemotherapy in the treatment of cutaneous melanoma metastases and rare non-melanoma skin cancer. Anticancer Res 40:6485–6492 PubMed
33.
Zurück zum Zitat Borgognoni L, Pescitelli L, Urso C et al (2014) A rare case of anal porocarcinoma treated by electrochemotherapy. Future Oncol 10:2429–2434 PubMed Borgognoni L, Pescitelli L, Urso C et al (2014) A rare case of anal porocarcinoma treated by electrochemotherapy. Future Oncol 10:2429–2434 PubMed
34.
Zurück zum Zitat Ribero S, Baduel ES, Brizio M et al (2016) Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality. Radiol Oncol 50:308–312 PubMedPubMedCentral Ribero S, Baduel ES, Brizio M et al (2016) Metastatic sebaceous cell carcinoma, review of the literature and use of electrochemotherapy as possible new treatment modality. Radiol Oncol 50:308–312 PubMedPubMedCentral
35.
Zurück zum Zitat Wakabayashi A, Tanese K, Yamamoto K et al (2010) Extraocular sebaceous carcinoma expressing oestrogen receptor alpha and human epidermal growth factor receptor 2. Clin Exp Dermatol 35:546–548 PubMed Wakabayashi A, Tanese K, Yamamoto K et al (2010) Extraocular sebaceous carcinoma expressing oestrogen receptor alpha and human epidermal growth factor receptor 2. Clin Exp Dermatol 35:546–548 PubMed
36.
Zurück zum Zitat Tanese K, Wakabayashi A, Suzuki T et al (2010) Immunoexpression of human epidermal growth factor receptor‑2 in apocrine carcinoma arising in naevus sebaceous, case report. J Eur Acad Dermatol Venereol 24:360–362 PubMed Tanese K, Wakabayashi A, Suzuki T et al (2010) Immunoexpression of human epidermal growth factor receptor‑2 in apocrine carcinoma arising in naevus sebaceous, case report. J Eur Acad Dermatol Venereol 24:360–362 PubMed
37.
Zurück zum Zitat Ohi Y, Kosuge H, Tanese K (2015) Case of syringomatous carcinoma: Positive immunohistochemical staining of c‑KIT and phosphorylated-extracellular signal-regulated kinase 1/2. J Dermatol 42:1191–1192 PubMed Ohi Y, Kosuge H, Tanese K (2015) Case of syringomatous carcinoma: Positive immunohistochemical staining of c‑KIT and phosphorylated-extracellular signal-regulated kinase 1/2. J Dermatol 42:1191–1192 PubMed
38.
Zurück zum Zitat Hiatt KM, Pillow JL, Smoller BR (2004) Her‑2 expression in cutaneous eccrine and apocrine neoplasms. Mod Pathol 17:28–32 PubMed Hiatt KM, Pillow JL, Smoller BR (2004) Her‑2 expression in cutaneous eccrine and apocrine neoplasms. Mod Pathol 17:28–32 PubMed
39.
Zurück zum Zitat Duverger L, Osio A, Cribier B et al (2019) Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas. Cancer Immunol Immunother 68:951–960 PubMed Duverger L, Osio A, Cribier B et al (2019) Heterogeneity of PD-L1 expression and CD8 tumor-infiltrating lymphocytes among subtypes of cutaneous adnexal carcinomas. Cancer Immunol Immunother 68:951–960 PubMed
40.
Zurück zum Zitat Soni A, Bansal N, Kaushal V et al (2015) Current management approach to hidradenocarcinoma: a comprehensive review of the literature. Ecancermedicalscience 9:517 PubMedPubMedCentral Soni A, Bansal N, Kaushal V et al (2015) Current management approach to hidradenocarcinoma: a comprehensive review of the literature. Ecancermedicalscience 9:517 PubMedPubMedCentral
41.
42.
Zurück zum Zitat Robson A, Greene J, Ansari N et al (2001) Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol 25:710–720 PubMed Robson A, Greene J, Ansari N et al (2001) Eccrine porocarcinoma (malignant eccrine poroma): a clinicopathologic study of 69 cases. Am J Surg Pathol 25:710–720 PubMed
43.
Zurück zum Zitat Nazemi A, Higgins S, Swift R et al (2018) Eccrine porocarcinoma: new insights and a systematic review of the literature. Dermatol Surg 44:1247–1261 PubMed Nazemi A, Higgins S, Swift R et al (2018) Eccrine porocarcinoma: new insights and a systematic review of the literature. Dermatol Surg 44:1247–1261 PubMed
44.
Zurück zum Zitat Herrmann JL, Allan A, Trapp KM et al (2014) Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis. J Am Acad Dermatol 71:38–43.e32 PubMed Herrmann JL, Allan A, Trapp KM et al (2014) Pilomatrix carcinoma: 13 new cases and review of the literature with emphasis on predictors of metastasis. J Am Acad Dermatol 71:38–43.e32 PubMed
45.
Zurück zum Zitat Leiter U, Heppt MV, Steeb T et al (2020) S3-Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 2: Epidemiologie, chirurgische und systemische Therapie des Plattenepithelkarzinoms, Nachsorge, Prävention und Berufskrankheit. J Dtsch Dermatol Ges 18:400–413 PubMed Leiter U, Heppt MV, Steeb T et al (2020) S3-Leitlinie „Aktinische Keratose und Plattenepithelkarzinom der Haut“ – Kurzfassung, Teil 2: Epidemiologie, chirurgische und systemische Therapie des Plattenepithelkarzinoms, Nachsorge, Prävention und Berufskrankheit. J Dtsch Dermatol Ges 18:400–413 PubMed
46.
Zurück zum Zitat Mehregan AH, Hashimoto K, Rahbari H (1983) Eccrine adenocarcinoma. A clinicopathologic study of 35 cases. Arch Dermatol 119:104–114 PubMed Mehregan AH, Hashimoto K, Rahbari H (1983) Eccrine adenocarcinoma. A clinicopathologic study of 35 cases. Arch Dermatol 119:104–114 PubMed
47.
Zurück zum Zitat Marone U, Caracò C, Anniciello AM et al (2011) Metastatic eccrine porocarcinoma: report of a case and review of the literature. World J Surg Oncol 9:32 PubMedPubMedCentral Marone U, Caracò C, Anniciello AM et al (2011) Metastatic eccrine porocarcinoma: report of a case and review of the literature. World J Surg Oncol 9:32 PubMedPubMedCentral
48.
Zurück zum Zitat Kurokawa M, Amano M, Miyaguni H et al (2001) Eccrine poromas in a patient with mycosis fungoides treated with electron beam therapy. Br J Dermatol 145:830–833 PubMed Kurokawa M, Amano M, Miyaguni H et al (2001) Eccrine poromas in a patient with mycosis fungoides treated with electron beam therapy. Br J Dermatol 145:830–833 PubMed
49.
Zurück zum Zitat Shaw M, Mckee PH, Lowe D et al (1982) Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol 107:675–680 PubMed Shaw M, Mckee PH, Lowe D et al (1982) Malignant eccrine poroma: a study of twenty-seven cases. Br J Dermatol 107:675–680 PubMed
50.
Zurück zum Zitat Song SS, Wu LW, Hamman MS et al (2015) Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. Dermatol Surg 41:301–306 PubMed Song SS, Wu LW, Hamman MS et al (2015) Mohs micrographic surgery for eccrine porocarcinoma: an update and review of the literature. Dermatol Surg 41:301–306 PubMed
51.
Zurück zum Zitat Snow SN, Reizner GT (1992) Eccrine porocarcinoma of the face. J Am Acad Dermatol 27:306–311 PubMed Snow SN, Reizner GT (1992) Eccrine porocarcinoma of the face. J Am Acad Dermatol 27:306–311 PubMed
52.
Zurück zum Zitat Ahn CS, Sangüeza OP (2019) Malignant sweat gland tumors. Hematol Oncol Clin North Am 33:53–71 PubMed Ahn CS, Sangüeza OP (2019) Malignant sweat gland tumors. Hematol Oncol Clin North Am 33:53–71 PubMed
53.
Zurück zum Zitat Nguyen A, Nguyen AV (2014) Eccrine porocarcinoma: a report of 2 cases and review of the literature. Cutis 93:43–46 PubMed Nguyen A, Nguyen AV (2014) Eccrine porocarcinoma: a report of 2 cases and review of the literature. Cutis 93:43–46 PubMed
54.
Zurück zum Zitat Tsunoda K, Onishi M, Maeda F et al (2019) Evaluation of sentinel lymph node biopsy for eccrine porocarcinoma. Acta Derm Venereol 99:691–692 PubMed Tsunoda K, Onishi M, Maeda F et al (2019) Evaluation of sentinel lymph node biopsy for eccrine porocarcinoma. Acta Derm Venereol 99:691–692 PubMed
55.
Zurück zum Zitat Salih AM, Kakamad FH, Baba HO et al (2017) Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg 20:74–79 Salih AM, Kakamad FH, Baba HO et al (2017) Porocarcinoma; presentation and management, a meta-analysis of 453 cases. Ann Med Surg 20:74–79
56.
Zurück zum Zitat Bogner PN, Fullen DR, Lowe L et al (2003) Lymphatic mapping and sentinel lymph node biopsy in the detection of early metastasis from sweat gland carcinoma. Cancer 97:2285–2289 PubMed Bogner PN, Fullen DR, Lowe L et al (2003) Lymphatic mapping and sentinel lymph node biopsy in the detection of early metastasis from sweat gland carcinoma. Cancer 97:2285–2289 PubMed
57.
Zurück zum Zitat Khaja M, Ashraf U, Mehershahi S et al (2019) Recurrent metastatic eccrine porocarcinoma: a case report and review of the literature. Am J Case Rep 20:179–183 PubMedPubMedCentral Khaja M, Ashraf U, Mehershahi S et al (2019) Recurrent metastatic eccrine porocarcinoma: a case report and review of the literature. Am J Case Rep 20:179–183 PubMedPubMedCentral
58.
Zurück zum Zitat Godillot C, Boulinguez S, Riffaud L et al (2018) Complete response of a metastatic porocarcinoma treated with paclitaxel, cetuximab and radiotherapy. Eur J Cancer 90:142–145 PubMed Godillot C, Boulinguez S, Riffaud L et al (2018) Complete response of a metastatic porocarcinoma treated with paclitaxel, cetuximab and radiotherapy. Eur J Cancer 90:142–145 PubMed
60.
Zurück zum Zitat Sa HS, Rubin ML, Xu S et al (2019) Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. Br J Ophthalmol 103:980–984 PubMed Sa HS, Rubin ML, Xu S et al (2019) Prognostic factors for local recurrence, metastasis and survival for sebaceous carcinoma of the eyelid: observations in 100 patients. Br J Ophthalmol 103:980–984 PubMed
61.
Zurück zum Zitat Roberts ME, Riegert-Johnson DL, Thomas BC et al (2014) A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome. Genet Med 16:711–716 PubMed Roberts ME, Riegert-Johnson DL, Thomas BC et al (2014) A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch syndrome. Genet Med 16:711–716 PubMed
62.
Zurück zum Zitat Kibbi N, Worley B, Owen JL et al (2020) Sebaceous carcinoma: controversies and their evidence for clinical practice. Arch Dermatol Res 312:25–31 PubMed Kibbi N, Worley B, Owen JL et al (2020) Sebaceous carcinoma: controversies and their evidence for clinical practice. Arch Dermatol Res 312:25–31 PubMed
63.
Zurück zum Zitat Carroll P, Goldstein GD, Brown CW Jr. (2000) Metastatic microcystic adnexal carcinoma in an immunocompromised patient. Dermatol Surg 26:531–534 PubMed Carroll P, Goldstein GD, Brown CW Jr. (2000) Metastatic microcystic adnexal carcinoma in an immunocompromised patient. Dermatol Surg 26:531–534 PubMed
Metadaten
Titel
Management von malignen Adnextumoren der Haut
verfasst von
Pia Nagel
Verena Müller
Prof. Dr. Jochen Utikal
Publikationsdatum
16.06.2021