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01.06.2019 | Review

Malnutrition and sarcopenia

verfasst von: Cornel C. Sieber

Erschienen in: Aging Clinical and Experimental Research | Ausgabe 6/2019

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Abstract

Risk for or established malnutrition is frequent in older adults, accompanied by functional limitations, increased morbidity and mortality. Protein-energy malnutrition is often observed and leads besides other predisposing factors to sarcopenia, the increased loss of muscle mass with aging. Sarcopenia is an integral correlate of the physical component of the frailty syndrome. Even though sarcopenia often reaches levels where mobility, balance and functionality on overall are hampered, its diagnosis has not become part of the standard diagnostic and therapeutic repertoire of geriatric medicine. This will hopefully change with a recently published revised international definition of sarcopenia, as well an own ICD-number. From a pathophysiological point of view, both malnutrition and sarcopenia share many components, a low-inflammatory state (inflamm-aging) being an important one. Nutritional interventions with and without parallel physical activity programs can prevent and often also reverse sarcopenia. It is hoped that upcoming even more potent nutritional treatment options—including for sarcopenic obesity—will lower the burden of malnutrition and sarcopenia for many older adults.
Literatur
2.
Zurück zum Zitat Morley JE (2001) Decreased food intake with aging. J Gerontol A Biol Sci Med Sci 56(Suppl. 2):81–88CrossRefPubMed Morley JE (2001) Decreased food intake with aging. J Gerontol A Biol Sci Med Sci 56(Suppl. 2):81–88CrossRefPubMed
3.
Zurück zum Zitat Kaiser M, Bauer JM, Ramsch C et al (2009) MNA-International Group. J Nutr Health Aging 13:782–788CrossRefPubMed Kaiser M, Bauer JM, Ramsch C et al (2009) MNA-International Group. J Nutr Health Aging 13:782–788CrossRefPubMed
4.
Zurück zum Zitat Frontera WR, Hughes VA, Fielding R et al (2000) Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol 88:1321–1326CrossRefPubMed Frontera WR, Hughes VA, Fielding R et al (2000) Aging of skeletal muscle: a 12-yr longitudinal study. J Appl Physiol 88:1321–1326CrossRefPubMed
5.
Zurück zum Zitat Baumgartner RN, Waters LW (2006) Sarcopenia and sarcopenic-obesity. In: Pathy MS, Sinclair AJ, Morley JE (eds) Principles and practice of geriatric medicine. Wiley, Chichester, pp 909–933 Baumgartner RN, Waters LW (2006) Sarcopenia and sarcopenic-obesity. In: Pathy MS, Sinclair AJ, Morley JE (eds) Principles and practice of geriatric medicine. Wiley, Chichester, pp 909–933
6.
Zurück zum Zitat Goodpaster B, Won Park S, Harris TB et al (2006) THe loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition Study. J Gerontol Biol Sci Med Sci 61A:1059–1064CrossRef Goodpaster B, Won Park S, Harris TB et al (2006) THe loss of skeletal muscle strength, mass, and quality in older adults: The Health, Aging and Body Composition Study. J Gerontol Biol Sci Med Sci 61A:1059–1064CrossRef
7.
Zurück zum Zitat Ferrucci L, Guralnik JM, Buchner D et al (2007) Departures of linearity tin the relationship between measures of muscular strength and physical performance of the lower extremities.: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 52:M275–M285 Ferrucci L, Guralnik JM, Buchner D et al (2007) Departures of linearity tin the relationship between measures of muscular strength and physical performance of the lower extremities.: the Women’s Health and Aging Study. J Gerontol A Biol Sci Med Sci 52:M275–M285
9.
10.
Zurück zum Zitat Fried L, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156CrossRefPubMed Fried L, Tangen CM, Walston J et al (2001) Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 56:M146–M156CrossRefPubMed
11.
Zurück zum Zitat Deutz NE, Bauer JM, Barazzoni R et al (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr 33:929–936CrossRefPubMedPubMedCentral Deutz NE, Bauer JM, Barazzoni R et al (2014) Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group. Clin Nutr 33:929–936CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Bauer JM, Biolo G, Cederholm T et al (2013) Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 14:542–559CrossRefPubMed Bauer JM, Biolo G, Cederholm T et al (2013) Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc 14:542–559CrossRefPubMed
13.
Zurück zum Zitat Goisser S, Kemmler W, Porzel S et al (2015) Sarcopenic obesity and complex interventions with nutrition and exercise in community-dwelling older persons—a narrative review. Clin Interv Aging 10:1267–1682PubMedPubMedCentral Goisser S, Kemmler W, Porzel S et al (2015) Sarcopenic obesity and complex interventions with nutrition and exercise in community-dwelling older persons—a narrative review. Clin Interv Aging 10:1267–1682PubMedPubMedCentral
14.
Zurück zum Zitat Barazzoni R, Bischoff SC, Boirie Y et al (2018) Sarcopenic obesity: time to meet the challenge. Clin Nutr 37:1787–1793CrossRefPubMed Barazzoni R, Bischoff SC, Boirie Y et al (2018) Sarcopenic obesity: time to meet the challenge. Clin Nutr 37:1787–1793CrossRefPubMed
15.
Zurück zum Zitat Cederholm T, Hellström K (1995) Reversibility of protein-energy malnutrition in a group of chronically ill elderly out-patients. Clin Nutr 14:81–87CrossRefPubMed Cederholm T, Hellström K (1995) Reversibility of protein-energy malnutrition in a group of chronically ill elderly out-patients. Clin Nutr 14:81–87CrossRefPubMed
18.
Zurück zum Zitat Jensen GL, Cederholm T, Correia MITD et al (2019) GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community. JPEN 43:32–40CrossRef Jensen GL, Cederholm T, Correia MITD et al (2019) GLIM criteria for the diagnosis of malnutrition—a consensus report from the global clinical nutrition community. JPEN 43:32–40CrossRef
19.
Zurück zum Zitat Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127(5 Suppl):990S–991SCrossRefPubMed Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127(5 Suppl):990S–991SCrossRefPubMed
20.
21.
Zurück zum Zitat Malmstrom TK, Miller DK, Simonsick EM et al (2016) SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle 7:28–36CrossRefPubMed Malmstrom TK, Miller DK, Simonsick EM et al (2016) SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle 7:28–36CrossRefPubMed
22.
Zurück zum Zitat Antunes AC, Araujo DA, Verissimo MT et al (2017) Sarcopenia and hospitalisation costs in older adults: a cross-sectional study. Nutr Diet 74:46–50CrossRefPubMed Antunes AC, Araujo DA, Verissimo MT et al (2017) Sarcopenia and hospitalisation costs in older adults: a cross-sectional study. Nutr Diet 74:46–50CrossRefPubMed
23.
Zurück zum Zitat Steffl M, Sima J, Shiells K et al (2017) The increase in health care costs associated with muscle weakness in older people without long-term illness in the Czech Republic: results from the Survey of Health, Ageing and Retirement in Europe (SHARE). Clin Interv Aging 12:2003–2007CrossRefPubMedPubMedCentral Steffl M, Sima J, Shiells K et al (2017) The increase in health care costs associated with muscle weakness in older people without long-term illness in the Czech Republic: results from the Survey of Health, Ageing and Retirement in Europe (SHARE). Clin Interv Aging 12:2003–2007CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat De Buyser SI, Petrovic M, Taes YE et al (2016) Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Age Ageing 45:602–608CrossRefPubMed De Buyser SI, Petrovic M, Taes YE et al (2016) Validation of the FNIH sarcopenia criteria and SOF frailty index as predictors of long-term mortality in ambulatory older men. Age Ageing 45:602–608CrossRefPubMed
25.
Zurück zum Zitat Janssen I, Heymsfield SB, Robert R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50:889–896CrossRefPubMed Janssen I, Heymsfield SB, Robert R (2002) Low relative skeletal muscle mass (sarcopenia) in older persons is associated with functional impairment and physical disability. J Am Geriatr Soc 50:889–896CrossRefPubMed
26.
Zurück zum Zitat Cruz-Jentoft AJ, Bayeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis. Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423CrossRefPubMedPubMedCentral Cruz-Jentoft AJ, Bayeyens JP, Bauer JM et al (2010) Sarcopenia: European consensus on definition and diagnosis. Report of the European Working Group on Sarcopenia in Older People. Age Ageing 39:412–423CrossRefPubMedPubMedCentral
27.
Zurück zum Zitat Muscaritoli M, Anker SD, Argiles J et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 29:154–159CrossRefPubMed Muscaritoli M, Anker SD, Argiles J et al (2010) Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”. Clin Nutr 29:154–159CrossRefPubMed
29.
Zurück zum Zitat Vellas B, Fielding RA, Bens C et al (2018) Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 7:2–9PubMed Vellas B, Fielding RA, Bens C et al (2018) Implications of ICD-10 for sarcopenia clinical practice and clinical trials: report by the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 7:2–9PubMed
30.
Zurück zum Zitat Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing 48:16–31CrossRefPubMed Cruz-Jentoft AJ, Bahat G, Bauer J et al (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age and Ageing 48:16–31CrossRefPubMed
32.
Zurück zum Zitat Zamboni M, Mazzali G, Fantin F et al (2008) Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 18:388–395CrossRefPubMed Zamboni M, Mazzali G, Fantin F et al (2008) Sarcopenic obesity: a new category of obesity in the elderly. Nutr Metab Cardiovasc Dis 18:388–395CrossRefPubMed
33.
Zurück zum Zitat Kemmler W, Teschler M, Weissenfels A et al (2017) Prevalence of sarcopenia and sarcopenic obesity in older German neb using recognized definitions: high accordance but low overlap! Osteoporosis Int 28:1881–1891CrossRef Kemmler W, Teschler M, Weissenfels A et al (2017) Prevalence of sarcopenia and sarcopenic obesity in older German neb using recognized definitions: high accordance but low overlap! Osteoporosis Int 28:1881–1891CrossRef
34.
Zurück zum Zitat Evans WJ, Morley JE, Argiles J et al (2008) Cachexia: a new definition. Clin Nutr 27:793–799CrossRefPubMed Evans WJ, Morley JE, Argiles J et al (2008) Cachexia: a new definition. Clin Nutr 27:793–799CrossRefPubMed
35.
Zurück zum Zitat Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489–495CrossRefPubMed Fearon K, Strasser F, Anker SD et al (2011) Definition and classification of cancer cachexia: an international consensus. Lancet Oncol 12:489–495CrossRefPubMed
36.
Zurück zum Zitat Salvioli S, Capri M, Valensin S et al (2006) Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systemic biology. Curr Pharm Des 12:3161–3171CrossRefPubMed Salvioli S, Capri M, Valensin S et al (2006) Inflamm-aging, cytokines and aging: state of the art, new hypotheses on the role of mitochondria and new perspectives from systemic biology. Curr Pharm Des 12:3161–3171CrossRefPubMed
37.
Zurück zum Zitat Walston J, McBurnie MA, Newman A et al (2002) Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 162:2333–2341CrossRefPubMed Walston J, McBurnie MA, Newman A et al (2002) Frailty and activation of the inflammation and coagulation systems with and without clinical comorbidities: results from the Cardiovascular Health Study. Arch Intern Med 162:2333–2341CrossRefPubMed
38.
Zurück zum Zitat Leng SX, Tian X, Matteini A, Li H et al (2011) IL6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Age Ageing 40:475–481CrossRefPubMedPubMedCentral Leng SX, Tian X, Matteini A, Li H et al (2011) IL6-independent association of elevated serum neopterin levels with prevalent frailty in community-dwelling older adults. Age Ageing 40:475–481CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Landi F, Cesari M, Calvani R et al (2017) The “Sarcopenia and Physical fRailty IN older people: multicomponent Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. Aging Clin Exp Res 28:89–100CrossRef Landi F, Cesari M, Calvani R et al (2017) The “Sarcopenia and Physical fRailty IN older people: multicomponent Treatment strategies” (SPRINTT) randomized controlled trial: design and methods. Aging Clin Exp Res 28:89–100CrossRef
40.
Zurück zum Zitat Landi F, Sieber C, Fielding RA et al (2018) Nutritional Intervention in Sarcopenia: report from the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 7:247–252PubMed Landi F, Sieber C, Fielding RA et al (2018) Nutritional Intervention in Sarcopenia: report from the International Conference on Frailty and Sarcopenia Research Task Force. J Frailty Aging 7:247–252PubMed
41.
Zurück zum Zitat Vasquez-Morales A, Wanden-Berghe C, Sanz-Valero J (2012) Exercise and nutritional supplements: effects of combined use in people over 65 years: a systematic review. Nutr Hosp 28:1077–1084 Vasquez-Morales A, Wanden-Berghe C, Sanz-Valero J (2012) Exercise and nutritional supplements: effects of combined use in people over 65 years: a systematic review. Nutr Hosp 28:1077–1084
42.
Zurück zum Zitat Wright J, Baldwin C (2018) Oral nutritional support with or without exercise in the management of malnutrition in nutritionally vulnerable older people: a systematic review and meta-analysis. Clin Nutr 37:1879–1891CrossRefPubMed Wright J, Baldwin C (2018) Oral nutritional support with or without exercise in the management of malnutrition in nutritionally vulnerable older people: a systematic review and meta-analysis. Clin Nutr 37:1879–1891CrossRefPubMed
43.
Zurück zum Zitat Dent E, Morley JE, Cruz-Jentoft AJ et al (2018) International Clinical Practice Guidelines for Sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging 22:1148–1161CrossRefPubMed Dent E, Morley JE, Cruz-Jentoft AJ et al (2018) International Clinical Practice Guidelines for Sarcopenia (ICFSR): screening, diagnosis and management. J Nutr Health Aging 22:1148–1161CrossRefPubMed
44.
Zurück zum Zitat Fiatarone MA, O’Neill EF, Ryan ND et al (1994) Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330:1769–1775CrossRefPubMed Fiatarone MA, O’Neill EF, Ryan ND et al (1994) Exercise training and nutritional supplementation for physical frailty in very elderly people. N Engl J Med 330:1769–1775CrossRefPubMed
45.
Zurück zum Zitat Milne AC, Potter J, Vivanti A et al (2009) Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 15:CD003288 Milne AC, Potter J, Vivanti A et al (2009) Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev 15:CD003288
46.
Zurück zum Zitat Wilkinson DJ, Hossain T, Hill DS et al (2013) Effects of leucine and its metabolite beta-hydroxy-beta-methybutyrate on human skeletal muscle protein metabolism. J Physiol 591:2911–2923CrossRefPubMedPubMedCentral Wilkinson DJ, Hossain T, Hill DS et al (2013) Effects of leucine and its metabolite beta-hydroxy-beta-methybutyrate on human skeletal muscle protein metabolism. J Physiol 591:2911–2923CrossRefPubMedPubMedCentral
47.
Zurück zum Zitat Katsanos CS, Aarsland A, Cree MG et al (2009) Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab 94:2984–2990CrossRefPubMedPubMedCentral Katsanos CS, Aarsland A, Cree MG et al (2009) Muscle protein synthesis and balance responsiveness to essential amino acids ingestion in the presence of elevated plasma free fatty acid concentrations. J Clin Endocrinol Metab 94:2984–2990CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Komar B, Schwingshackl L, Hoffmann G (2015) Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging 19:437–446CrossRefPubMed Komar B, Schwingshackl L, Hoffmann G (2015) Effects of leucine-rich protein supplements on anthropometric parameter and muscle strength in the elderly: a systematic review and meta-analysis. J Nutr Health Aging 19:437–446CrossRefPubMed
49.
Zurück zum Zitat Bauer JM, Verlaan S, Bautmans I et al (2015) Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the provide study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16:740–747CrossRefPubMed Bauer JM, Verlaan S, Bautmans I et al (2015) Effects of a vitamin D and leucine-enriched whey protein nutritional supplement on measures of sarcopenia in older adults, the provide study: a randomized, double-blind, placebo-controlled trial. J Am Med Dir Assoc 16:740–747CrossRefPubMed
51.
Zurück zum Zitat Liberman K, Njemini R, Luiking Y et al (2019) 13 weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low grade inflammation in sarcopenic frail older adults: the PROVIDE study. Aging Clin Exp Res (in press) Liberman K, Njemini R, Luiking Y et al (2019) 13 weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low grade inflammation in sarcopenic frail older adults: the PROVIDE study. Aging Clin Exp Res (in press)
Metadaten
Titel
Malnutrition and sarcopenia
verfasst von
Cornel C. Sieber
Publikationsdatum
01.06.2019
Verlag
Springer International Publishing
Erschienen in
Aging Clinical and Experimental Research / Ausgabe 6/2019
Elektronische ISSN: 1720-8319
DOI
https://doi.org/10.1007/s40520-019-01170-1

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