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Erschienen in: Breast Cancer Research 5/2010

01.10.2010 | Viewpoint

Mammary stem cells and cancer: roles of Wnt signaling in plain view

verfasst von: Alexander M Many, Anthony MC Brown

Erschienen in: Breast Cancer Research | Ausgabe 5/2010

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Abstract

The likely roles of Wnt signaling in regulating mammary stem cell behavior have been much discussed, in part because they may underlie the oncogenic effects of Wnt signaling in mammary tissue. Two recent papers add important data to this field. One tests directly the effects of purified Wnt protein on mouse mammary stem cells in culture and finds a specific increase in the proportion of cells with self-renewing stem cell phenotypes. The second identifies a novel target gene of canonical Wnt signaling that may be expressed in stem cells and is induced in both mouse and human mammary tumors associated with Wnt pathway activation.
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Metadaten
Titel
Mammary stem cells and cancer: roles of Wnt signaling in plain view
verfasst von
Alexander M Many
Anthony MC Brown
Publikationsdatum
01.10.2010
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 5/2010
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2631

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