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Breast Cancer Research
Erschienen in: Breast Cancer Research 3/2005

01.06.2005 | Review

Mammary stem cells, self-renewal pathways, and carcinogenesis

verfasst von: Suling Liu, Gabriela Dontu, Max S Wicha

Erschienen in: Breast Cancer Research | Ausgabe 3/2005

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Abstract

The mammary gland epithelial components are thought to arise from stem cells that undergo both self-renewal and differentiation. Self-renewal has been shown to be regulated by the Hedgehog, Notch, and Wnt pathways and the transcription factor B lymphoma Mo-MLV insertion region 1 (Bmi-1). We review data about the existence of stem cells in the mammary gland and the pathways regulating the self-renewal of these cells. We present evidence that deregulation of the self-renewal in stem cells/progenitors might be a key event in mammary carcinogenesis. If 'tumor stem cells' are inherently resistant to current therapies, targeting stem cell self-renewal pathways might provide a novel approach for breast cancer treatment.
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Metadaten
Titel
Mammary stem cells, self-renewal pathways, and carcinogenesis
verfasst von
Suling Liu
Gabriela Dontu
Max S Wicha
Publikationsdatum
01.06.2005
Verlag
BioMed Central
Erschienen in
Breast Cancer Research / Ausgabe 3/2005
Elektronische ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1021

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