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16.11.2023 | Narrative review

Management of collagenous gastritis in children: Case series and literature review

verfasst von: Sara Isoldi, Franca Viola, Salvatore Cucchiara, Anna Dilillo, Donatella Iorfida, Anna Maria Testi, Francesco Fiorentino, Saverio Mallardo

Erschienen in: Indian Journal of Gastroenterology | Ausgabe 3/2024

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Abstract

Collagenous gastritis (CG) is a rare histopathological finding on gastric biopsies in children. It is associated with abdominal pain and iron deficiency anemia, usually not respondent to oral iron supplements. The aim of this study was to describe our experience in the management of pediatric patients with CG. Moreover, we propose to review the literature on this topic. We retrospectively reviewed all pediatric patients diagnosed with CG at our centre from January 2014 to January 2019. Three pediatric patients (2 F, mean age 12.3) were diagnosed with CG during the study period. Two presented with moderate and one with severe anemia. Symptoms were abdominal pain, asthenia and headache in two and asthenia and abdominal pain in one. All underwent upper and lower gastrointestinal endoscopy. All were firstly started with oral iron supplements with no benefit, principally due to poor compliance secondary to the worsening of the epigastric pain and proton pump inhibitor resistance. Therefore, they underwent ferric carboxymaltose (FCM) infusion with good clinical and laboratory response. Patients received a mean of two infusions/year, with stable hemoglobin levels and no adverse outcomes. Our review failed to identify a consistent response to specific treatments. Considering the apparent benign nature of the disease, symptomatic and supportive treatments are advisable. Iron deficiency anemia is largely present and therapy with oral iron supplements is not always successful. In our study, FCM infusion was effective in increasing the key blood indices in patients who poorly tolerated oral supplements.

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Metadaten
Titel
Management of collagenous gastritis in children: Case series and literature review
verfasst von
Sara Isoldi
Franca Viola
Salvatore Cucchiara
Anna Dilillo
Donatella Iorfida
Anna Maria Testi
Francesco Fiorentino
Saverio Mallardo
Publikationsdatum
16.11.2023
Verlag
Springer India
Erschienen in
Indian Journal of Gastroenterology / Ausgabe 3/2024
Print ISSN: 0254-8860
Elektronische ISSN: 0975-0711
DOI
https://doi.org/10.1007/s12664-023-01472-3

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