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Erschienen in: Digestive Diseases and Sciences 8/2016

11.04.2016 | Review

Management of Inflammatory Bowel Disease During Pregnancy

verfasst von: Ariella Bar-Gil Shitrit, Sorina Grisaru-Granovsky, Ami Ben Ya’acov, Eran Goldin

Erschienen in: Digestive Diseases and Sciences | Ausgabe 8/2016

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Abstract

Inflammatory bowel disease (IBD) usually affects women during their reproductive years and many concerns arise among these young patients. Pre-pregnancy consultation with a multi-disciplinary team is very important. The team should make patients aware of the critical importance of ensuring that conception occurs during a period of disease remission. Conception during an IBD flare-up results in disease activity or even exacerbates disease in two-thirds of women. Exacerbation of the disease is associated with increased frequency of maternal and fetal complications. Drug therapy constitutes a considerable source of patient anxiety but most drugs used for treating IBD are considered safe. Therefore, continuing pharmacological therapy during pregnancy is necessary to maintain disease control. Optimization of pre-conception nutritional status and smoking cessation are also emphasized. The general guideline for most patients, except for active perianal disease patients, is to aim for vaginal delivery in the absence of obstetric contraindications. Consistent, ongoing follow-up, as detailed in this review, should allay the anxieties and fears surrounding continuing immunosuppressive drugs during pregnancy, allowing each patient to attain the optimal conditions for achieving her goal of holding a healthy baby.
Literatur
1.
Zurück zum Zitat Marri SR, Ahn C, Buchman AL. Voluntary childlessness is increased in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:591–599.CrossRefPubMed Marri SR, Ahn C, Buchman AL. Voluntary childlessness is increased in women with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13:591–599.CrossRefPubMed
2.
Zurück zum Zitat Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohn’s Colitis. 2013;7:e206–e213.CrossRef Selinger CP, Eaden J, Selby W, et al. Inflammatory bowel disease and pregnancy: lack of knowledge is associated with negative views. J Crohn’s Colitis. 2013;7:e206–e213.CrossRef
3.
Zurück zum Zitat Mountifield R, Andrews JM, Bampton P. It IS worth the effort: Patient knowledge of reproductive aspects of inflammatory bowel disease improves dramatically after a single group education session. J Crohn’s Colitis. 2014;8:796–801.CrossRef Mountifield R, Andrews JM, Bampton P. It IS worth the effort: Patient knowledge of reproductive aspects of inflammatory bowel disease improves dramatically after a single group education session. J Crohn’s Colitis. 2014;8:796–801.CrossRef
5.
Zurück zum Zitat Huang VW, Habal FM. From conception to delivery: managing the pregnant inflammatory bowel disease patient. World J Gastroenterol. 2014;20:3495–3506.CrossRefPubMedPubMedCentral Huang VW, Habal FM. From conception to delivery: managing the pregnant inflammatory bowel disease patient. World J Gastroenterol. 2014;20:3495–3506.CrossRefPubMedPubMedCentral
6.
Zurück zum Zitat Ban L, Tata LJ, Humes DJ, Fiaschi L, Card T. Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study. Aliment Pharmacol Ther. 2015;42:855–866.CrossRefPubMed Ban L, Tata LJ, Humes DJ, Fiaschi L, Card T. Decreased fertility rates in 9639 women diagnosed with inflammatory bowel disease: a United Kingdom population-based cohort study. Aliment Pharmacol Ther. 2015;42:855–866.CrossRefPubMed
7.
Zurück zum Zitat Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 1990;99:987–994.CrossRefPubMed Baird DD, Narendranathan M, Sandler RS. Increased risk of preterm birth for women with inflammatory bowel disease. Gastroenterology. 1990;99:987–994.CrossRefPubMed
8.
Zurück zum Zitat Hudson M, Flett G, Sinclair TS, Brunt PW, Templeton A, Mowat NA. Fertility and pregnancy in inflammatory bowel disease. Int J Gynaecol Obstet. 1997;58:229–237.CrossRefPubMed Hudson M, Flett G, Sinclair TS, Brunt PW, Templeton A, Mowat NA. Fertility and pregnancy in inflammatory bowel disease. Int J Gynaecol Obstet. 1997;58:229–237.CrossRefPubMed
9.
Zurück zum Zitat Senates E, Colak Y, Erdem ED, et al. Serum anti-Mullerian hormone levels are lower in reproductive-age women with Crohn’s disease compared to healthy control women. J Crohn’s Colitis. 2013;7:e29–e34.CrossRef Senates E, Colak Y, Erdem ED, et al. Serum anti-Mullerian hormone levels are lower in reproductive-age women with Crohn’s disease compared to healthy control women. J Crohn’s Colitis. 2013;7:e29–e34.CrossRef
10.
Zurück zum Zitat Freour T, Miossec C, Bach-Ngohou K, et al. Ovarian reserve in young women of reproductive age with Crohn’s disease. Inflamm Bowel Dis. 2012;18:1515–1522.CrossRefPubMed Freour T, Miossec C, Bach-Ngohou K, et al. Ovarian reserve in young women of reproductive age with Crohn’s disease. Inflamm Bowel Dis. 2012;18:1515–1522.CrossRefPubMed
11.
Zurück zum Zitat Lamah M, Scott HJ. Inflammatory bowel disease and pregnancy. Int J Colorectal Dis. 2002;17:216–222.CrossRefPubMed Lamah M, Scott HJ. Inflammatory bowel disease and pregnancy. Int J Colorectal Dis. 2002;17:216–222.CrossRefPubMed
12.
Zurück zum Zitat Waljee A, Waljee J, Morris AM, Higgins PD. Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Gut. 2006;55:1575–1580.CrossRefPubMedPubMedCentral Waljee A, Waljee J, Morris AM, Higgins PD. Threefold increased risk of infertility: a meta-analysis of infertility after ileal pouch anal anastomosis in ulcerative colitis. Gut. 2006;55:1575–1580.CrossRefPubMedPubMedCentral
13.
Zurück zum Zitat Johnson P, Richard C, Ravid A, et al. Female infertility after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2004;47:1119–1126.CrossRefPubMed Johnson P, Richard C, Ravid A, et al. Female infertility after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2004;47:1119–1126.CrossRefPubMed
14.
Zurück zum Zitat Rajaratnam SG, Eglinton TW, Hider P, Fearnhead NS. Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review. Int J Colorectal Dis. 2011;26:1365–1374.CrossRefPubMed Rajaratnam SG, Eglinton TW, Hider P, Fearnhead NS. Impact of ileal pouch-anal anastomosis on female fertility: meta-analysis and systematic review. Int J Colorectal Dis. 2011;26:1365–1374.CrossRefPubMed
15.
Zurück zum Zitat Tulchinsky H, Averboukh F, Horowitz N, et al. Restorative proctocolectomy impairs fertility and pregnancy outcomes in women with ulcerative colitis. Colorectal Dis. 2013;15:842–847.CrossRefPubMed Tulchinsky H, Averboukh F, Horowitz N, et al. Restorative proctocolectomy impairs fertility and pregnancy outcomes in women with ulcerative colitis. Colorectal Dis. 2013;15:842–847.CrossRefPubMed
16.
Zurück zum Zitat Wikland M, Jansson I, Asztely M, et al. Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy. Int J Colorectal Dis. 1990;5:49–52.CrossRefPubMed Wikland M, Jansson I, Asztely M, et al. Gynaecological problems related to anatomical changes after conventional proctocolectomy and ileostomy. Int J Colorectal Dis. 1990;5:49–52.CrossRefPubMed
17.
Zurück zum Zitat Olsen KO, Juul S, Bulow S, et al. Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg. 2003;90:227–231.CrossRefPubMed Olsen KO, Juul S, Bulow S, et al. Female fecundity before and after operation for familial adenomatous polyposis. Br J Surg. 2003;90:227–231.CrossRefPubMed
18.
Zurück zum Zitat Van Horn C, Barrett P. Pregnancy, delivery, and postpartum experiences of fifty-four women with ostomies. J Wound Ostomy Continence Nurs. 1997;24:151–162.CrossRefPubMed Van Horn C, Barrett P. Pregnancy, delivery, and postpartum experiences of fifty-four women with ostomies. J Wound Ostomy Continence Nurs. 1997;24:151–162.CrossRefPubMed
19.
Zurück zum Zitat Hill J, Clark A, Scott NA. Surgical treatment of acute manifestations of Crohn’s disease during pregnancy. J R Soc Med. 1997;90:64–66.PubMedPubMedCentral Hill J, Clark A, Scott NA. Surgical treatment of acute manifestations of Crohn’s disease during pregnancy. J R Soc Med. 1997;90:64–66.PubMedPubMedCentral
20.
Zurück zum Zitat Visser BC, Glasgow RE, Mulvihill KK, Mulvihill SJ. Safety and timing of nonobstetric abdominal surgery in pregnancy. Dig Surg. 2001;18:409–417.CrossRefPubMed Visser BC, Glasgow RE, Mulvihill KK, Mulvihill SJ. Safety and timing of nonobstetric abdominal surgery in pregnancy. Dig Surg. 2001;18:409–417.CrossRefPubMed
21.
Zurück zum Zitat Kane S. Inflammatory bowel disease in pregnancy. Gastroenterol Clin N Am. 2003;32:323–340.CrossRef Kane S. Inflammatory bowel disease in pregnancy. Gastroenterol Clin N Am. 2003;32:323–340.CrossRef
22.
Zurück zum Zitat Juhasz ES, Fozard B, Dozois RR, Ilstrup DM, Nelson H. Ileal pouch-anal anastomosis function following childbirth. An extended evaluation. Dis Colon Rectum. 1995;38:159–165.CrossRefPubMed Juhasz ES, Fozard B, Dozois RR, Ilstrup DM, Nelson H. Ileal pouch-anal anastomosis function following childbirth. An extended evaluation. Dis Colon Rectum. 1995;38:159–165.CrossRefPubMed
23.
Zurück zum Zitat Bush MC, Patel S, Lapinski RH, Stone JL. Perinatal outcomes in inflammatory bowel disease. J Maternal-Fetal Neonatal Med. 2004;15:237–241.CrossRef Bush MC, Patel S, Lapinski RH, Stone JL. Perinatal outcomes in inflammatory bowel disease. J Maternal-Fetal Neonatal Med. 2004;15:237–241.CrossRef
24.
Zurück zum Zitat Abhyankar A, Ham M, Moss AC. Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:460–466.CrossRefPubMedPubMedCentral Abhyankar A, Ham M, Moss AC. Meta-analysis: the impact of disease activity at conception on disease activity during pregnancy in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2013;38:460–466.CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Cornish J, Tan E, Teare J, et al. A meta-analysis on the influence of inflammatory bowel disease on pregnancy. Gut. 2007;56:830–837.CrossRefPubMed Cornish J, Tan E, Teare J, et al. A meta-analysis on the influence of inflammatory bowel disease on pregnancy. Gut. 2007;56:830–837.CrossRefPubMed
26.
Zurück zum Zitat O’Toole A, Nwanne O, Tomlinson T. Inflammatory bowel disease increases risk of adverse pregnancy outcomes: a meta-analysis. Dig Dis Sci. 2015;60:2750–2761.CrossRefPubMed O’Toole A, Nwanne O, Tomlinson T. Inflammatory bowel disease increases risk of adverse pregnancy outcomes: a meta-analysis. Dig Dis Sci. 2015;60:2750–2761.CrossRefPubMed
27.
Zurück zum Zitat Elbaz G, Fich A, Levy A, Holcberg G, Sheiner E. Inflammatory bowel disease and preterm delivery. Int J Gynaecol Obstet. 2005;90:193–197.CrossRefPubMed Elbaz G, Fich A, Levy A, Holcberg G, Sheiner E. Inflammatory bowel disease and preterm delivery. Int J Gynaecol Obstet. 2005;90:193–197.CrossRefPubMed
28.
Zurück zum Zitat Mahadevan U, Sandborn WJ, Li DK, Hakimian S, Kane S, Corley DA. Pregnancy outcomes in women with inflammatory bowel disease: a large community-based study from Northern California. Gastroenterology. 2007;133:1106–1112.CrossRefPubMed Mahadevan U, Sandborn WJ, Li DK, Hakimian S, Kane S, Corley DA. Pregnancy outcomes in women with inflammatory bowel disease: a large community-based study from Northern California. Gastroenterology. 2007;133:1106–1112.CrossRefPubMed
29.
Zurück zum Zitat Molnar T, Farkas K, Nagy F, et al. Pregnancy outcome in patients with inflammatory bowel disease according to the activity of the disease and the medical treatment: a case–control study. Scand J Gastroenterol. 2010;45:1302–1306.CrossRefPubMed Molnar T, Farkas K, Nagy F, et al. Pregnancy outcome in patients with inflammatory bowel disease according to the activity of the disease and the medical treatment: a case–control study. Scand J Gastroenterol. 2010;45:1302–1306.CrossRefPubMed
30.
Zurück zum Zitat Norgard B, Hundborg HH, Jacobsen BA, Nielsen GL, Fonager K. Disease activity in pregnant women with Crohn’s disease and birth outcomes: a regional Danish cohort study. Am J Gastroenterol. 2007;102:1947–1954.CrossRefPubMed Norgard B, Hundborg HH, Jacobsen BA, Nielsen GL, Fonager K. Disease activity in pregnant women with Crohn’s disease and birth outcomes: a regional Danish cohort study. Am J Gastroenterol. 2007;102:1947–1954.CrossRefPubMed
31.
Zurück zum Zitat Dotan I, Alper A, Rachmilewitz D, et al. Maternal inflammatory bowel disease has short and long-term effects on the health of their offspring: a multicenter study in Israel. J Crohn’s Colitis. 2013;7:542–550.CrossRef Dotan I, Alper A, Rachmilewitz D, et al. Maternal inflammatory bowel disease has short and long-term effects on the health of their offspring: a multicenter study in Israel. J Crohn’s Colitis. 2013;7:542–550.CrossRef
32.
Zurück zum Zitat Ban L, Tata LJ, Fiaschi L, Card T. Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications. Gastroenterology. 2014;146:76–84.CrossRefPubMed Ban L, Tata LJ, Fiaschi L, Card T. Limited risks of major congenital anomalies in children of mothers with IBD and effects of medications. Gastroenterology. 2014;146:76–84.CrossRefPubMed
33.
Zurück zum Zitat Reddy D, Murphy SJ, Kane SV, Present DH, Kornbluth AA. Relapses of inflammatory bowel disease during pregnancy: in-hospital management and birth outcomes. Am J Gastroenterol. 2008;103:1203–1209.CrossRefPubMed Reddy D, Murphy SJ, Kane SV, Present DH, Kornbluth AA. Relapses of inflammatory bowel disease during pregnancy: in-hospital management and birth outcomes. Am J Gastroenterol. 2008;103:1203–1209.CrossRefPubMed
34.
Zurück zum Zitat Habal FM, Huang VW. Review article: a decision-making algorithm for the management of pregnancy in the inflammatory bowel disease patient. Aliment Pharmacol Ther. 2012;35:501–515.CrossRefPubMed Habal FM, Huang VW. Review article: a decision-making algorithm for the management of pregnancy in the inflammatory bowel disease patient. Aliment Pharmacol Ther. 2012;35:501–515.CrossRefPubMed
35.
36.
Zurück zum Zitat van der Woude CJ, Ardizzone S, Bengtson MB, et al. The second european evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohn’s Colitis. 2015;9:107–124.CrossRef van der Woude CJ, Ardizzone S, Bengtson MB, et al. The second european evidenced-based consensus on reproduction and pregnancy in inflammatory bowel disease. J Crohn’s Colitis. 2015;9:107–124.CrossRef
38.
Zurück zum Zitat Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut. 2006;55:i36–i58.CrossRefPubMedPubMedCentral Caprilli R, Gassull MA, Escher JC, et al. European evidence based consensus on the diagnosis and management of Crohn’s disease: special situations. Gut. 2006;55:i36–i58.CrossRefPubMedPubMedCentral
39.
Zurück zum Zitat Keller J, Frederking D, Layer P. The spectrum and treatment of gastrointestinal disorders during pregnancy. Nat Clin Pract Gastroenterol Hepatol. 2008;5:430–443.CrossRefPubMed Keller J, Frederking D, Layer P. The spectrum and treatment of gastrointestinal disorders during pregnancy. Nat Clin Pract Gastroenterol Hepatol. 2008;5:430–443.CrossRefPubMed
40.
Zurück zum Zitat Schulze H, Esters P, Dignass A. Review article: the management of Crohn’s disease and ulcerative colitis during pregnancy and lactation. Aliment Pharmacol Ther. 2014;40:991–1008.CrossRefPubMed Schulze H, Esters P, Dignass A. Review article: the management of Crohn’s disease and ulcerative colitis during pregnancy and lactation. Aliment Pharmacol Ther. 2014;40:991–1008.CrossRefPubMed
41.
Zurück zum Zitat Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006;131:283–311.CrossRefPubMed Mahadevan U, Kane S. American gastroenterological association institute technical review on the use of gastrointestinal medications in pregnancy. Gastroenterology. 2006;131:283–311.CrossRefPubMed
42.
Zurück zum Zitat Gawron LM, Hammond C, Keefer L. Documentation of reproductive health counseling and contraception in women with inflammatory bowel diseases. Patient Educ Couns. 2014;94:134–137.CrossRefPubMed Gawron LM, Hammond C, Keefer L. Documentation of reproductive health counseling and contraception in women with inflammatory bowel diseases. Patient Educ Couns. 2014;94:134–137.CrossRefPubMed
43.
Zurück zum Zitat Mountifield RE, Prosser R, Bampton P, Muller K, Andrews JM. Pregnancy and IBD treatment: this challenging interplay from a patients’ perspective. J Crohn’s Colitis. 2010;4:176–182.CrossRef Mountifield RE, Prosser R, Bampton P, Muller K, Andrews JM. Pregnancy and IBD treatment: this challenging interplay from a patients’ perspective. J Crohn’s Colitis. 2010;4:176–182.CrossRef
44.
Zurück zum Zitat Julsgaard M, Norgaard M, Hvas CL, Buck D, Christensen LA. Self-reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis. Inflamm Bowel Dis. 2011;17:1573–1580.CrossRefPubMed Julsgaard M, Norgaard M, Hvas CL, Buck D, Christensen LA. Self-reported adherence to medical treatment prior to and during pregnancy among women with ulcerative colitis. Inflamm Bowel Dis. 2011;17:1573–1580.CrossRefPubMed
45.
Zurück zum Zitat Selinger CP, Eaden J, Jones DB, et al. Modifiable factors associated with nonadherence to maintenance medication for inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:2199–2206.CrossRefPubMed Selinger CP, Eaden J, Jones DB, et al. Modifiable factors associated with nonadherence to maintenance medication for inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:2199–2206.CrossRefPubMed
46.
Zurück zum Zitat Nielsen OH, Maxwell C, Hendel J. IBD medications during pregnancy and lactation. Nat Rev Gastroenterol Hepatol.. 2014;11:116–127.CrossRefPubMed Nielsen OH, Maxwell C, Hendel J. IBD medications during pregnancy and lactation. Nat Rev Gastroenterol Hepatol.. 2014;11:116–127.CrossRefPubMed
47.
Zurück zum Zitat Diav-Citrin O, Park YH, Veerasuntharam G, et al. The safety of mesalamine in human pregnancy: a prospective controlled cohort study. Gastroenterology. 1998;114:23–28.CrossRefPubMed Diav-Citrin O, Park YH, Veerasuntharam G, et al. The safety of mesalamine in human pregnancy: a prospective controlled cohort study. Gastroenterology. 1998;114:23–28.CrossRefPubMed
48.
Zurück zum Zitat Marteau P, Tennenbaum R, Elefant E, Lemann M, Cosnes J. Foetal outcome in women with inflammatory bowel disease treated during pregnancy with oral mesalazine microgranules. Aliment Pharmacol Ther. 1998;12:1101–1108.CrossRefPubMed Marteau P, Tennenbaum R, Elefant E, Lemann M, Cosnes J. Foetal outcome in women with inflammatory bowel disease treated during pregnancy with oral mesalazine microgranules. Aliment Pharmacol Ther. 1998;12:1101–1108.CrossRefPubMed
49.
Zurück zum Zitat Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol. 2008;25:271–275.CrossRefPubMed Rahimi R, Nikfar S, Rezaie A, Abdollahi M. Pregnancy outcome in women with inflammatory bowel disease following exposure to 5-aminosalicylic acid drugs: a meta-analysis. Reprod Toxicol. 2008;25:271–275.CrossRefPubMed
50.
Zurück zum Zitat Saillenfait AM, Payan JP, Fabry JP, et al. Assessment of the developmental toxicity, metabolism, and placental transfer of di-n-butyl phthalate administered to pregnant rats. Toxicol Sci. 1998;45:212–224.CrossRefPubMed Saillenfait AM, Payan JP, Fabry JP, et al. Assessment of the developmental toxicity, metabolism, and placental transfer of di-n-butyl phthalate administered to pregnant rats. Toxicol Sci. 1998;45:212–224.CrossRefPubMed
51.
Zurück zum Zitat Gallinger ZR, Nguyen GC. Presence of phthalates in gastrointestinal medications: is there a hidden danger? World J Gastroenterol. 2013;19:7042–7047.CrossRefPubMedPubMedCentral Gallinger ZR, Nguyen GC. Presence of phthalates in gastrointestinal medications: is there a hidden danger? World J Gastroenterol. 2013;19:7042–7047.CrossRefPubMedPubMedCentral
52.
Zurück zum Zitat Hernandez-Diaz S, Mitchell AA, Kelley KE, Calafat AM, Hauser R. Medications as a potential source of exposure to phthalates in the U.S. population. Environ Health Perspect. 2009;117:185–189.CrossRefPubMed Hernandez-Diaz S, Mitchell AA, Kelley KE, Calafat AM, Hauser R. Medications as a potential source of exposure to phthalates in the U.S. population. Environ Health Perspect. 2009;117:185–189.CrossRefPubMed
53.
Zurück zum Zitat Jarnerot G, Into-Malmberg MB, Esbjorner E. Placental transfer of sulphasalazine and sulphapyridine and some of its metabolites. Scand J Gastroenterol. 1981;16:693–697.CrossRefPubMed Jarnerot G, Into-Malmberg MB, Esbjorner E. Placental transfer of sulphasalazine and sulphapyridine and some of its metabolites. Scand J Gastroenterol. 1981;16:693–697.CrossRefPubMed
54.
Zurück zum Zitat Esbjorner E, Jarnerot G, Wranne L. Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulphasalazine during pregnancy and lactation. Acta Paediatr Scand. 1987;76:137–142.CrossRefPubMed Esbjorner E, Jarnerot G, Wranne L. Sulphasalazine and sulphapyridine serum levels in children to mothers treated with sulphasalazine during pregnancy and lactation. Acta Paediatr Scand. 1987;76:137–142.CrossRefPubMed
55.
Zurück zum Zitat Branski D, Kerem E, Gross-Kieselstein E, Hurvitz H, Litt R, Abrahamov A. Bloody diarrhea–a possible complication of sulfasalazine transferred through human breast milk. J Pediatr Gastroenterol Nutr. 1986;5:316–317.CrossRefPubMed Branski D, Kerem E, Gross-Kieselstein E, Hurvitz H, Litt R, Abrahamov A. Bloody diarrhea–a possible complication of sulfasalazine transferred through human breast milk. J Pediatr Gastroenterol Nutr. 1986;5:316–317.CrossRefPubMed
56.
Zurück zum Zitat Park-Wyllie L, Mazzotta P, Pastuszak A, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000;62:385–392.CrossRefPubMed Park-Wyllie L, Mazzotta P, Pastuszak A, et al. Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology. 2000;62:385–392.CrossRefPubMed
57.
Zurück zum Zitat Carmichael SL, Shaw GM, Ma C, Werler MM, Rasmussen SA, Lammer EJ. Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol. 2007;197:585 e581–587 (discussion 683–584, e581–587). Carmichael SL, Shaw GM, Ma C, Werler MM, Rasmussen SA, Lammer EJ. Maternal corticosteroid use and orofacial clefts. Am J Obstet Gynecol. 2007;197:585 e581–587 (discussion 683–584, e581–587).
58.
Zurück zum Zitat Gur C, Diav-Citrin O, Shechtman S, Arnon J, Ornoy A. Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study. Reprod Toxicol. 2004;18:93–101.CrossRefPubMed Gur C, Diav-Citrin O, Shechtman S, Arnon J, Ornoy A. Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study. Reprod Toxicol. 2004;18:93–101.CrossRefPubMed
60.
61.
Zurück zum Zitat Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81:936–945.CrossRefPubMed Beitins IZ, Bayard F, Ances IG, Kowarski A, Migeon CJ. The transplacental passage of prednisone and prednisolone in pregnancy near term. J Pediatr. 1972;81:936–945.CrossRefPubMed
62.
Zurück zum Zitat Ost L, Wettrell G, Bjorkhem I, Rane A. Prednisolone excretion in human milk. J Pediatr. 1985;106:1008–1011.CrossRefPubMed Ost L, Wettrell G, Bjorkhem I, Rane A. Prednisolone excretion in human milk. J Pediatr. 1985;106:1008–1011.CrossRefPubMed
63.
Zurück zum Zitat Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohn’s Colitis. 2010;4:63–101.CrossRef Van Assche G, Dignass A, Reinisch W, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: special situations. J Crohn’s Colitis. 2010;4:63–101.CrossRef
64.
Zurück zum Zitat Polifka JE, Friedman JM. Teratogen update: azathioprine and 6-mercaptopurine. Teratology. 2002;65:240–261.CrossRefPubMed Polifka JE, Friedman JM. Teratogen update: azathioprine and 6-mercaptopurine. Teratology. 2002;65:240–261.CrossRefPubMed
65.
Zurück zum Zitat de Boer NK, Jarbandhan SV, de Graaf P, Mulder CJ, van Elburg RM, van Bodegraven AA. Azathioprine use during pregnancy: unexpected intrauterine exposure to metabolites. Am J Gastroenterol. 2006;101:1390–1392.CrossRefPubMed de Boer NK, Jarbandhan SV, de Graaf P, Mulder CJ, van Elburg RM, van Bodegraven AA. Azathioprine use during pregnancy: unexpected intrauterine exposure to metabolites. Am J Gastroenterol. 2006;101:1390–1392.CrossRefPubMed
66.
Zurück zum Zitat Coelho J, Beaugerie L, Colombel JF, et al. Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study. Gut. 2011;60:198–203.CrossRefPubMed Coelho J, Beaugerie L, Colombel JF, et al. Pregnancy outcome in patients with inflammatory bowel disease treated with thiopurines: cohort from the CESAME Study. Gut. 2011;60:198–203.CrossRefPubMed
67.
Zurück zum Zitat Jharap B, de Boer NK, Stokkers P, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014;63:451–457.CrossRefPubMed Jharap B, de Boer NK, Stokkers P, et al. Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease. Gut. 2014;63:451–457.CrossRefPubMed
68.
Zurück zum Zitat Akbari M, Shah S, Velayos FS, Mahadevan U, Cheifetz AS. Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:15–22.CrossRefPubMed Akbari M, Shah S, Velayos FS, Mahadevan U, Cheifetz AS. Systematic review and meta-analysis on the effects of thiopurines on birth outcomes from female and male patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19:15–22.CrossRefPubMed
69.
Zurück zum Zitat Baiocco PJ, Korelitz BI. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol. 1984;6:211–216.PubMed Baiocco PJ, Korelitz BI. The influence of inflammatory bowel disease and its treatment on pregnancy and fetal outcome. J Clin Gastroenterol. 1984;6:211–216.PubMed
70.
Zurück zum Zitat Christensen LA, Dahlerup JF, Nielsen MJ, Fallingborg JF, Schmiegelow K. Azathioprine treatment during lactation. Aliment Pharmacol Ther. 2008;28:1209–1213.CrossRefPubMed Christensen LA, Dahlerup JF, Nielsen MJ, Fallingborg JF, Schmiegelow K. Azathioprine treatment during lactation. Aliment Pharmacol Ther. 2008;28:1209–1213.CrossRefPubMed
71.
Zurück zum Zitat Branche J, Cortot A, Bourreille A, et al. Cyclosporine treatment of steroid-refractory ulcerative colitis during pregnancy. Inflamm Bowel Dis. 2009;15:1044–1048.CrossRefPubMed Branche J, Cortot A, Bourreille A, et al. Cyclosporine treatment of steroid-refractory ulcerative colitis during pregnancy. Inflamm Bowel Dis. 2009;15:1044–1048.CrossRefPubMed
72.
Zurück zum Zitat Moretti ME, Sgro M, Johnson DW, et al. Cyclosporine excretion into breast milk. Transplantation. 2003;75:2144–2146.CrossRefPubMed Moretti ME, Sgro M, Johnson DW, et al. Cyclosporine excretion into breast milk. Transplantation. 2003;75:2144–2146.CrossRefPubMed
73.
Zurück zum Zitat Brandt LJ, Estabrook SG, Reinus JF. Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn’s disease. Am J Gastroenterol. 1995;90:1918–1922.PubMed Brandt LJ, Estabrook SG, Reinus JF. Results of a survey to evaluate whether vaginal delivery and episiotomy lead to perineal involvement in women with Crohn’s disease. Am J Gastroenterol. 1995;90:1918–1922.PubMed
74.
Zurück zum Zitat Johns DG, Rutherford LD, Leighton PC, Vogel CL. Secretion of methotrexate into human milk. Am J Obstet Gynecol.. 1972;112:978–980.CrossRefPubMed Johns DG, Rutherford LD, Leighton PC, Vogel CL. Secretion of methotrexate into human milk. Am J Obstet Gynecol.. 1972;112:978–980.CrossRefPubMed
75.
Zurück zum Zitat Srinivasan R, Akobeng AK. Thalidomide and thalidomide analogues for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2009:CD007350. Srinivasan R, Akobeng AK. Thalidomide and thalidomide analogues for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2009:CD007350.
76.
Zurück zum Zitat Mahadevan U, Cucchiara S, Hyams JS, et al. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn’s and Colitis Organisation: pregnancy and pediatrics. Am J Gastroenterol 2011;106:214–223 (quiz 224). Mahadevan U, Cucchiara S, Hyams JS, et al. The London Position Statement of the World Congress of Gastroenterology on Biological Therapy for IBD with the European Crohn’s and Colitis Organisation: pregnancy and pediatrics. Am J Gastroenterol 2011;106:214–223 (quiz 224).
77.
Zurück zum Zitat Kane SV, Acquah LA. Placental transport of immunoglobulins: a clinical review for gastroenterologists who prescribe therapeutic monoclonal antibodies to women during conception and pregnancy. Am J Gastroenterol. 2009;104:228–233.CrossRefPubMed Kane SV, Acquah LA. Placental transport of immunoglobulins: a clinical review for gastroenterologists who prescribe therapeutic monoclonal antibodies to women during conception and pregnancy. Am J Gastroenterol. 2009;104:228–233.CrossRefPubMed
78.
Zurück zum Zitat Mahadevan U, Martin C, Chambers CD, et al. Achievement of developmental milestones among offspring of women with inflammatory bowel disease: the PIANO registry. Gastroenterology. 2014;146:S–1. Mahadevan U, Martin C, Chambers CD, et al. Achievement of developmental milestones among offspring of women with inflammatory bowel disease: the PIANO registry. Gastroenterology. 2014;146:S–1.
79.
Zurück zum Zitat A SPECIAL MEETING REVIEW EDITION: Highlights in Crohn’s Disease and Ulcerative Colitis: Digestive Disease Week 2012 May 19-22, 2012 * San Diego, CaliforniaSpecial Reporting on:* Safety and Efficacy of Subcutaneous Golimumab Induction Therapy in Patients with Moderately to Severely Active UC: PURSUIT-SC* The Future of IBD Therapy: Individualized and Optimized Therapy and Novel Mechanisms* Infliximab Concentration and Clinical Outcome in Patients with UC* Vedolizumab Induction Therapy for UC: Results of GEMINI I, A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase III Trial* Novel Infliximab and Antibody-to-lnfliximab Assays Are Predictive of Disease Activity in Patients with CD* Accelerated Step-Care Therapy with Early Azathioprine Versus Conventional Step-Care Therapy in CD* PIANO: A 1,000-Patient Prospective Registry of Pregnancy Outcomes in Women with IBD Exposed to Immunomodulators and Biologic TherapyPLUS Meeting Abstract Summaries With Expert Commentary by: William J. Sandborn, MDChief of the Division of Gastroenterology Director of the UCSD IBD Center UC San Diego Health System La Jolla, California. Gastroenterol Hepatol (N Y). 2012;8:1–24. A SPECIAL MEETING REVIEW EDITION: Highlights in Crohn’s Disease and Ulcerative Colitis: Digestive Disease Week 2012 May 19-22, 2012 * San Diego, CaliforniaSpecial Reporting on:* Safety and Efficacy of Subcutaneous Golimumab Induction Therapy in Patients with Moderately to Severely Active UC: PURSUIT-SC* The Future of IBD Therapy: Individualized and Optimized Therapy and Novel Mechanisms* Infliximab Concentration and Clinical Outcome in Patients with UC* Vedolizumab Induction Therapy for UC: Results of GEMINI I, A Randomized, Placebo-Controlled, Double-Blind, Multicenter, Phase III Trial* Novel Infliximab and Antibody-to-lnfliximab Assays Are Predictive of Disease Activity in Patients with CD* Accelerated Step-Care Therapy with Early Azathioprine Versus Conventional Step-Care Therapy in CD* PIANO: A 1,000-Patient Prospective Registry of Pregnancy Outcomes in Women with IBD Exposed to Immunomodulators and Biologic TherapyPLUS Meeting Abstract Summaries With Expert Commentary by: William J. Sandborn, MDChief of the Division of Gastroenterology Director of the UCSD IBD Center UC San Diego Health System La Jolla, California. Gastroenterol Hepatol (N Y). 2012;8:1–24.
80.
Zurück zum Zitat Zelinkova Z, de Haar C, de Ridder L, et al. High intra-uterine exposure to infliximab following maternal anti-TNF treatment during pregnancy. Aliment Pharmacol Ther. 2011;33:1053–1058.CrossRefPubMed Zelinkova Z, de Haar C, de Ridder L, et al. High intra-uterine exposure to infliximab following maternal anti-TNF treatment during pregnancy. Aliment Pharmacol Ther. 2011;33:1053–1058.CrossRefPubMed
81.
Zurück zum Zitat Zelinkova Z, van der Ent C, Bruin KF, et al. Effects of discontinuing anti-tumor necrosis factor therapy during pregnancy on the course of inflammatory bowel disease and neonatal exposure. Clin Gastroenterol Hepatol. 2013;11:318–321.CrossRefPubMed Zelinkova Z, van der Ent C, Bruin KF, et al. Effects of discontinuing anti-tumor necrosis factor therapy during pregnancy on the course of inflammatory bowel disease and neonatal exposure. Clin Gastroenterol Hepatol. 2013;11:318–321.CrossRefPubMed
82.
Zurück zum Zitat Gisbert JP, Chaparro M. Safety of anti-TNF agents during pregnancy and breastfeeding in women with inflammatory bowel disease. The American journal of gastroenterology.. 2013;108:1426–1438.CrossRefPubMed Gisbert JP, Chaparro M. Safety of anti-TNF agents during pregnancy and breastfeeding in women with inflammatory bowel disease. The American journal of gastroenterology.. 2013;108:1426–1438.CrossRefPubMed
83.
Zurück zum Zitat Lin K, Mahadevan U. Pharmacokinetics of biologics and the role of therapeutic monitoring. Gastroenterol Clin N Am. 2014;43:565–579.CrossRef Lin K, Mahadevan U. Pharmacokinetics of biologics and the role of therapeutic monitoring. Gastroenterol Clin N Am. 2014;43:565–579.CrossRef
84.
Zurück zum Zitat Ben-Horin S, Yavzori M, Kopylov U, et al. Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease. J Crohns Colitis. 2011;5:555–558.CrossRefPubMed Ben-Horin S, Yavzori M, Kopylov U, et al. Detection of infliximab in breast milk of nursing mothers with inflammatory bowel disease. J Crohns Colitis. 2011;5:555–558.CrossRefPubMed
86.
Zurück zum Zitat Kane S, Ford J, Cohen R, Wagner C. Absence of infliximab in infants and breast milk from nursing mothers receiving therapy for Crohn’s disease before and after delivery. J Clin Gastroenterol. 2009;43:613–616.CrossRefPubMed Kane S, Ford J, Cohen R, Wagner C. Absence of infliximab in infants and breast milk from nursing mothers receiving therapy for Crohn’s disease before and after delivery. J Clin Gastroenterol. 2009;43:613–616.CrossRefPubMed
87.
Zurück zum Zitat Ben-Horin S, Yavzori M, Katz L, et al. Adalimumab level in breast milk of a nursing mother. Clin Gastroenterol Hepatol. 2010;8:475–476.CrossRefPubMed Ben-Horin S, Yavzori M, Katz L, et al. Adalimumab level in breast milk of a nursing mother. Clin Gastroenterol Hepatol. 2010;8:475–476.CrossRefPubMed
88.
Zurück zum Zitat Chambers CD, Johnson DL. Emerging data on the use of anti-tumor necrosis factor-alpha medications in pregnancy. Birth Defects Res A Clin Mol Teratol. 2012;94:607–611.CrossRefPubMed Chambers CD, Johnson DL. Emerging data on the use of anti-tumor necrosis factor-alpha medications in pregnancy. Birth Defects Res A Clin Mol Teratol. 2012;94:607–611.CrossRefPubMed
89.
Zurück zum Zitat McConnell RA, Mahadevan U. Use of immunomodulators and biologics before, during, and after pregnancy. Inflamm Bowel Dis. 2016;22:213–223.CrossRefPubMed McConnell RA, Mahadevan U. Use of immunomodulators and biologics before, during, and after pregnancy. Inflamm Bowel Dis. 2016;22:213–223.CrossRefPubMed
90.
Zurück zum Zitat Mahadevan U, Nazareth M, Cristiano L, Kooijmans M, Hogge G. Natalizumab use during pregnancy. Am J Gastroenterol. 2012;103:S449. Mahadevan U, Nazareth M, Cristiano L, Kooijmans M, Hogge G. Natalizumab use during pregnancy. Am J Gastroenterol. 2012;103:S449.
91.
Zurück zum Zitat P563. Vedolizumab exposure in pregnancy: Outcomes from clinical studies in inflammatory bowel disease. J Crohn’s Colitis. 2015; 9:S361–S362. P563. Vedolizumab exposure in pregnancy: Outcomes from clinical studies in inflammatory bowel disease. J Crohn’s Colitis. 2015; 9:S361–S362.
92.
Zurück zum Zitat Nguyen GC, Boudreau H, Harris ML, Maxwell CV. Outcomes of obstetric hospitalizations among women with inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol. 2009;7:329–334.CrossRefPubMed Nguyen GC, Boudreau H, Harris ML, Maxwell CV. Outcomes of obstetric hospitalizations among women with inflammatory bowel disease in the United States. Clin Gastroenterol Hepatol. 2009;7:329–334.CrossRefPubMed
93.
Zurück zum Zitat Hou JK, Mahadevan U. A 24-year-old pregnant woman with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2009;7:944–947.CrossRefPubMed Hou JK, Mahadevan U. A 24-year-old pregnant woman with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2009;7:944–947.CrossRefPubMed
94.
Zurück zum Zitat Piper JM, Mitchel EF, Ray WA. Prenatal use of metronidazole and birth defects: no association. Obstet Gynecol. 1993;82:348–352.PubMed Piper JM, Mitchel EF, Ray WA. Prenatal use of metronidazole and birth defects: no association. Obstet Gynecol. 1993;82:348–352.PubMed
95.
Zurück zum Zitat Schwebke JR. Metronidazole: utilization in the obstetric and gynecologic patient. Sex Transm Dis. 1995;22:370–376.CrossRefPubMed Schwebke JR. Metronidazole: utilization in the obstetric and gynecologic patient. Sex Transm Dis. 1995;22:370–376.CrossRefPubMed
96.
Zurück zum Zitat Berkovitch M, Pastuszak A, Gazarian M, Lewis M, Koren G. Safety of the new quinolones in pregnancy. Obstet Gynecol. 1994;84:535–538.PubMed Berkovitch M, Pastuszak A, Gazarian M, Lewis M, Koren G. Safety of the new quinolones in pregnancy. Obstet Gynecol. 1994;84:535–538.PubMed
97.
Zurück zum Zitat Gardner DK, Gabbe SG, Harter C. Simultaneous concentrations of ciprofloxacin in breast milk and in serum in mother and breast-fed infant. Clin Pharm. 1992;11:352–354.PubMed Gardner DK, Gabbe SG, Harter C. Simultaneous concentrations of ciprofloxacin in breast milk and in serum in mother and breast-fed infant. Clin Pharm. 1992;11:352–354.PubMed
98.
Zurück zum Zitat Manosa M, Navarro-Llavat M, Marin L, Zabana Y, Cabre E, Domenech E. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013;48:427–432.CrossRefPubMed Manosa M, Navarro-Llavat M, Marin L, Zabana Y, Cabre E, Domenech E. Fecundity, pregnancy outcomes, and breastfeeding in patients with inflammatory bowel disease: a large cohort survey. Scand J Gastroenterol. 2013;48:427–432.CrossRefPubMed
99.
Zurück zum Zitat Ananthakrishnan AN, Cheng A, Cagan A, et al. Mode of childbirth and long-term outcomes in women with inflammatory bowel diseases. Dig Dis Sci. 2015;60:471–477.CrossRefPubMed Ananthakrishnan AN, Cheng A, Cagan A, et al. Mode of childbirth and long-term outcomes in women with inflammatory bowel diseases. Dig Dis Sci. 2015;60:471–477.CrossRefPubMed
100.
Zurück zum Zitat Remzi FH, Gorgun E, Bast J, et al. Vaginal delivery after ileal pouch-anal anastomosis: a word of caution. Dis Colon Rectum. 2005;48:1691–1699.CrossRefPubMed Remzi FH, Gorgun E, Bast J, et al. Vaginal delivery after ileal pouch-anal anastomosis: a word of caution. Dis Colon Rectum. 2005;48:1691–1699.CrossRefPubMed
101.
Zurück zum Zitat Nicholl MC, Thompson JM, Cocks PS. Stomas and pregnancy. Aust N Z J Obstet Gynaecol. 1993;33:322–324.CrossRefPubMed Nicholl MC, Thompson JM, Cocks PS. Stomas and pregnancy. Aust N Z J Obstet Gynaecol. 1993;33:322–324.CrossRefPubMed
102.
Zurück zum Zitat Ravid A, Richard CS, Spencer LM, et al. Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2002;45:1283–1288.CrossRefPubMed Ravid A, Richard CS, Spencer LM, et al. Pregnancy, delivery, and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2002;45:1283–1288.CrossRefPubMed
103.
Zurück zum Zitat Lepisto A, Sarna S, Tiitinen A, Jarvinen HJ. Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis. Br J Surg. 2007;94:478–482.CrossRefPubMed Lepisto A, Sarna S, Tiitinen A, Jarvinen HJ. Female fertility and childbirth after ileal pouch-anal anastomosis for ulcerative colitis. Br J Surg. 2007;94:478–482.CrossRefPubMed
104.
Zurück zum Zitat Ramalingam T, Box B, Mortensen NM. Pregnancy delivery and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2003;46:1292.CrossRefPubMed Ramalingam T, Box B, Mortensen NM. Pregnancy delivery and pouch function after ileal pouch-anal anastomosis for ulcerative colitis. Dis Colon Rectum. 2003;46:1292.CrossRefPubMed
105.
Zurück zum Zitat Hahnloser D, Pemberton JH, Wolff BG, et al. Pregnancy and delivery before and after ileal pouch-anal anastomosis for inflammatory bowel disease: immediate and long-term consequences and outcomes. Dis Colon Rectum. 2004;47:1127–1135.CrossRefPubMed Hahnloser D, Pemberton JH, Wolff BG, et al. Pregnancy and delivery before and after ileal pouch-anal anastomosis for inflammatory bowel disease: immediate and long-term consequences and outcomes. Dis Colon Rectum. 2004;47:1127–1135.CrossRefPubMed
Metadaten
Titel
Management of Inflammatory Bowel Disease During Pregnancy
verfasst von
Ariella Bar-Gil Shitrit
Sorina Grisaru-Granovsky
Ami Ben Ya’acov
Eran Goldin
Publikationsdatum
11.04.2016
Verlag
Springer US
Erschienen in
Digestive Diseases and Sciences / Ausgabe 8/2016
Print ISSN: 0163-2116
Elektronische ISSN: 1573-2568
DOI
https://doi.org/10.1007/s10620-016-4139-9

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