The online version of this article (doi:10.1186/1824-7288-40-18) contains supplementary material, which is available to authorized users.
The authors declare that they have no competing interests.
MC identified the case, suggested the diagnosis and drafted the manuscript. AQ and MP were involved in the diagnostic process, therapeutic decisions and follow up. IC helped in writing the manuscript and selecting bibliography. SG made substantial contribution to bronchoscopy studies. FMdB supervised the diagnostic and therapeutic approach, and critically revised the manuscript. All authors read and approved the final manuscript.
Plastic bronchitis is a rare complication of a variety of respiratory diseases and congenital heart disease surgery, particularly Fontan procedure. Bronchial casts with rubber-like consistency develop acutely and may cause severe life-threatening respiratory distress. The management of plastic bronchitis is yet not well defined. Early intermittent, self-administered nebulization of tissue plasminogen activator was found to be effective in preventing deterioration of acute respiratory symptoms in a patient with primary ciliary dyskinesia and recurrent cast formation. Further investigation into new therapeutic strategies for this devastating disease is advocated.
Authors’ original file for figure 113052_2013_354_MOESM1_ESM.jpeg
Heath L, Ling S, Racz J, Mane G, Schmidt JL, Tsai WC, Caruthers RL, Hirsch JC, Stringer KA: Prospective, longitudinal study of plastic bronchitis cast pathology and responsiveness to tissue plasminogen activator. Pediatr Cardiol. 2011, 32: 1182-1189. 10.1007/s00246-011-0058-x. PubMedCentralCrossRefPubMed
Lackowski NP, Pitzer JE, Tobias M, Van Rheen Z, Nayar R, Mosharaff M, Stringer KA: Safety of prolonged, repeated administration of a pulmonary formulation of tissue plasminogen activator in mice. Pulmon Pharmacol Ther. 2010, 23: 107-114. 10.1016/j.pupt.2009.10.009. CrossRef
Rubin BK, Moskowitz WB: Plastic bronchitis. Paediatric Respiratory Medicine. ERS Handbook. Edited by: Eber E, Midulla F. 2013, 577-580.
- Management of plastic bronchitis with nebulized tissue plasminogen activator: another brick in the wall
Fernando Maria de Benedictis
- BioMed Central
Neu im Fachgebiet Pädiatrie
Meistgelesene Bücher aus dem Fachgebiet
Mail Icon II