Background
Patients and methods
Patients
Infections
MBL2 genotyping
Statistical analysis
Ethics
Results
MBL2 structural variants, promoter polymorphisms and genotypes
AA
Patients (%) n = 53
|
AO/OO
Patients (%) n = 19
|
P-value*
| |
---|---|---|---|
Gender
| |||
Male | 30 (56.6) | 12 (63.2) | 0.62 |
Female | 23 (43.4) | 7 (36.8) | |
Mean age (SD), years
| 51.6 (13.9) | 50.2 (14.8) | 0.70 |
Underlying disease
| 0.78 | ||
MM | 14 (26.4) | 6 (31.6) | |
HD | 8 (15.1) | 5 (26.3) | |
NHL | 22 (41.5) | 7 (36.8) | |
AMN | 7 (13.2) | 1 (5.3) | |
PL | 1 (1.9) | 0 | |
Amyloidosis | 1 (1.9) | 0 | |
Active disease**
| 0.22 | ||
YES | 11 (20.8) | 7 (36.8) | |
NO | 42 (79.2) | 12 (63.2) |
AA
Patients (%) n = 53
|
AO/OO
Patients (%) n = 19
| P-value* | |
---|---|---|---|
0
| 1 (1.9) | 0 | 0.18 |
1
| 14 (26.4) | 5 (26.3) | |
2
| 26 (49.1) | 10 (52.6) | |
3
| 12 (22.6) | 2 (10.5) | |
4
| 0 | 2 (10.5) | |
Mean (SD)
| 1.9 (0.8) | 2.1 (0.9) | 0.55 |
Infections
AA
|
AO/OO
| RR (95% CI) |
P-value*
| |
---|---|---|---|---|
Patients (%)
|
Patients (%)
| |||
n = 53
|
n = 19
| |||
Types of Infection
| ||||
-Pneumonia | 2 (3.8) | 2 (10.5) | 2.8(0.4-18.4) | 0.28 |
-Sepsis | 22 (41.5) | 9 (47.4) | 1.1 (0.6-2.0) | 0.66 |
-VCI | 6 (11.3) | 2 (10.5) | 0.9 (0.2-4.2) | 1.00 |
-UTI | 5 (9.4) | 3 (15.8) | 1.7 (0.4-6.3) | 0.43 |
Major infection
| 6 (11.3) | 5 (26.3) | 2.32 (0.80-6.74) | 0.15 |
Gram-positive infections
| 14 (26.4) | 9 (47.4) | 1.8 (0.9-3.4) |
0.09
|
-S. epidermidis | 9 (17) | 7 (36.8) | 2.2 (0.9-5.0) | 0.11 |
-S. aureus | 1 (1.9) | 0 (0) | -- | 1.00 |
-Other | ||||
Gram-negative infections
| 19 (35.8) | 6 (31.6) | 0.9 (0.4-1.9) | 0.74 |
Viral infections
| 1 (1.9) | 1 (5.3) | 2.8 (0.2-42.4) | 0.46 |
-CMV | 0 (0) | 1 (5.3) | -- | 0.26 |
Fungal infections
| 1 (1.9) | 4 (21.1) | 11.5 (1.3-93.7) |
0.016
|
- Candida | 1(1.9) | 2 (10.5) | 5.6 (0.5-58.1) | 0.17 |
- Aspergillus | 0 (0) | 1 (5.3) | -- | 0.26 |
-Mucor | 0 (0) | 1 (5.3) | -- | 0.26 |
Nº deaths
| 4 (7.5) | 3 (15.8) | 2.1 (0.5-8.5) | 0.37 |
Cause of death
| ||||
-Infection | 0 | 3 | -- | 0.05 |
-Progression | 3 | 0 | -- | |
-Unknown (not infection) | 1 | 0 | -- |
Outcome variable (patients with infection) | OR* (95% CI) (Effect of MBL2 genotypes on risk of infection) |
p-value
|
---|---|---|
Types of infection
| ||
-Pneumonia | 8.1 (0.4-158.2) | 0.17 |
-Sepsis | 0.9 (0.3-3.1) | 0.88 |
-VCI | 0.8 (0.1-5.0) | 0.77 |
-UTI | 2.3 (0.4-12.8) | 0.44 |
Serious infection
| 0.8 (0.1-4.9) | 0.79 |
Gram-positive infections
| 2.5 (0.8-7.5) | 0.11 |
-S. epidermidis | 4.0 (1.0-16.5) | 0.05 |
Gram-negative infections
| 0.7 (0.2-2.4) | 0.59 |
Viral infections
| 1.1 (0.01-60.4) | 0.96 |
Fungal infections
| 12.9 (1.1-153.9) | 0.03 |