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Erschienen in: Journal of Cancer Survivorship 2/2021

15.08.2020 | Review

Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature

verfasst von: Belinda Thompson, Katrina Gaitatzis, Xanne Janse de Jonge, Robbie Blackwell, Louise A. Koelmeyer

Erschienen in: Journal of Cancer Survivorship | Ausgabe 2/2021

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Abstract

Purpose

Manual lymphatic drainage (MLD) massage is widely accepted as a conservative treatment for lymphedema. This systematic review aims to examine the methodologies used in recent research and evaluate the effectiveness of MLD for those at-risk of or living with lymphedema.

Methods

The electronic databases Embase, PubMed, CINAHL Complete and Cochrane Central Register of Controlled Trials were searched using relevant terms. Studies comparing MLD with another intervention or control in patients at-risk of or with lymphedema were included. Studies were critically appraised with the PEDro scale.

Results

Seventeen studies with a total of 867 female and two male participants were included. Only studies examining breast cancer-related lymphedema were identified. Some studies reported positive effects of MLD on volume reduction, quality of life and symptom-related outcomes compared with other treatments, while other studies reported no additional benefit of MLD as a component of complex decongestive therapy. In patients at-risk, MLD was reported to reduce incidence of lymphedema in some studies, while others reported no such benefits.

Conclusions

The reviewed articles reported conflicting findings and were often limited by methodological issues. This review highlights the need for further experimental studies on the effectiveness of MLD in lymphedema.

Implications for Cancer Survivors

There is some evidence that MLD in early stages following breast cancer surgery may help prevent progression to clinical lymphedema. MLD may also provide additional benefits in volume reduction for mild lymphedema. However, in moderate to severe lymphedema, MLD may not provide additional benefit when combined with complex decongestive therapy.
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Literatur
1.
Zurück zum Zitat Ridner SH. Pathophysiology of lymphedema. Semin Oncol Nurs. 2013;29(1):4–11.CrossRef Ridner SH. Pathophysiology of lymphedema. Semin Oncol Nurs. 2013;29(1):4–11.CrossRef
2.
Zurück zum Zitat Mortimer PS. The pathophysiology of lymphedema. Cancer. 1998;83(12 Suppl American):2798–802.CrossRef Mortimer PS. The pathophysiology of lymphedema. Cancer. 1998;83(12 Suppl American):2798–802.CrossRef
3.
Zurück zum Zitat Fu MR, Ridner SH, Hu SH, Stewart BR, Cormier JN, Armer JM. Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011. Psychooncology. 2013;22(7):1466–84.CrossRef Fu MR, Ridner SH, Hu SH, Stewart BR, Cormier JN, Armer JM. Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011. Psychooncology. 2013;22(7):1466–84.CrossRef
4.
Zurück zum Zitat Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: Globocan sources and methods. Int J Cancer. 2019;144(8):1941–53.CrossRef Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, et al. Estimating the global cancer incidence and mortality in 2018: Globocan sources and methods. Int J Cancer. 2019;144(8):1941–53.CrossRef
5.
Zurück zum Zitat Lawenda BD, Mondry TE, Johnstone PA. Lymphedema: a primer on the identification and management of a chronic condition in oncologic treatment. CA Cancer J Clin. 2009;59(1):8–24.CrossRef Lawenda BD, Mondry TE, Johnstone PA. Lymphedema: a primer on the identification and management of a chronic condition in oncologic treatment. CA Cancer J Clin. 2009;59(1):8–24.CrossRef
6.
Zurück zum Zitat Ko DS, Lerner R, Klose G, Cosimi AB. Effective treatment of lymphedema of the extremities. Arch Surg. 1998;133(4):452–8.CrossRef Ko DS, Lerner R, Klose G, Cosimi AB. Effective treatment of lymphedema of the extremities. Arch Surg. 1998;133(4):452–8.CrossRef
7.
Zurück zum Zitat Huang TW, Tseng SH, Lin CC, Bai CH, Chen CS, Hung CS, et al. Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials. World J Surg Oncol. 2013;11:15.CrossRef Huang TW, Tseng SH, Lin CC, Bai CH, Chen CS, Hung CS, et al. Effects of manual lymphatic drainage on breast cancer-related lymphedema: a systematic review and meta-analysis of randomized controlled trials. World J Surg Oncol. 2013;11:15.CrossRef
8.
Zurück zum Zitat Ezzo J, Manheimer E, Mcneely ML, Howell DM, Weiss R, Johansson KI et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database Syst Rev. 2015(5):Cd003475. Ezzo J, Manheimer E, Mcneely ML, Howell DM, Weiss R, Johansson KI et al. Manual lymphatic drainage for lymphedema following breast cancer treatment. Cochrane Database Syst Rev. 2015(5):Cd003475.
9.
Zurück zum Zitat Williams A. Manual lymphatic drainage: exploring the history and evidence base. Br J Commun Nurs. 2010;15(4):S18–24.CrossRef Williams A. Manual lymphatic drainage: exploring the history and evidence base. Br J Commun Nurs. 2010;15(4):S18–24.CrossRef
10.
Zurück zum Zitat Jenns K, Twycross RG. Todd J. Radcliffe Medical: Lymphoedema; 2000. Jenns K, Twycross RG. Todd J. Radcliffe Medical: Lymphoedema; 2000.
11.
Zurück zum Zitat Stuiver MM, Ten Tusscher MR, Agasi-Idenburg CS, Lucas C, Aaronson NK, Bossuyt PM. Conservative interventions for preventing clinically detectable upper-limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy. Cochrane Database Syst Rev. 2015;2:Cd009765. Stuiver MM, Ten Tusscher MR, Agasi-Idenburg CS, Lucas C, Aaronson NK, Bossuyt PM. Conservative interventions for preventing clinically detectable upper-limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy. Cochrane Database Syst Rev. 2015;2:Cd009765.
12.
Zurück zum Zitat Muller M, Klingberg K, Wertli MM, Carreira H. Manual lymphatic drainage and quality of life in patients with lymphoedema and mixed oedema: a systematic review of randomised controlled trials. Qual Life Res. 2018;27(6):1403–14.CrossRef Muller M, Klingberg K, Wertli MM, Carreira H. Manual lymphatic drainage and quality of life in patients with lymphoedema and mixed oedema: a systematic review of randomised controlled trials. Qual Life Res. 2018;27(6):1403–14.CrossRef
13.
Zurück zum Zitat Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015 statement. Syst Rev. 2015;4(1):1.CrossRef Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, et al. Preferred reporting items for systematic review and meta-analysis protocols (prisma-p) 2015 statement. Syst Rev. 2015;4(1):1.CrossRef
14.
Zurück zum Zitat Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713–21.CrossRef Maher CG, Sherrington C, Herbert RD, Moseley AM, Elkins M. Reliability of the PEDro scale for rating quality of randomized controlled trials. Phys Ther. 2003;83(8):713–21.CrossRef
15.
Zurück zum Zitat Moseley AM, Herbert RD, Sherrington C, Maher CG. Evidence for physiotherapy practice: a survey of the physiotherapy evidence database (PEDro). Aust J Physiother. 2002;48(1):43–9.CrossRef Moseley AM, Herbert RD, Sherrington C, Maher CG. Evidence for physiotherapy practice: a survey of the physiotherapy evidence database (PEDro). Aust J Physiother. 2002;48(1):43–9.CrossRef
16.
Zurück zum Zitat Review Manager (RevMan) [Computer program]. Version 5.4, The Cochrane Collaboration. 2020. Review Manager (RevMan) [Computer program]. Version 5.4, The Cochrane Collaboration. 2020.
17.
Zurück zum Zitat Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Erlbaum Associates: Hillsdale; 1988. Cohen J. Statistical power analysis for the behavioral sciences. 2nd ed. Erlbaum Associates: Hillsdale; 1988.
18.
Zurück zum Zitat Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane. 2019. Available from www.training.cochrane.org/handbook. Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors). Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane. 2019. Available from www.​training.​cochrane.​org/​handbook.
19.
Zurück zum Zitat Andersen L, Hojris I, Erlandsen M, Andersen J. Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized study. Acta Oncol. 2000;39(3):399–405.CrossRef Andersen L, Hojris I, Erlandsen M, Andersen J. Treatment of breast-cancer-related lymphedema with or without manual lymphatic drainage--a randomized study. Acta Oncol. 2000;39(3):399–405.CrossRef
20.
Zurück zum Zitat Belmonte R, Tejero M, Ferrer M, Muniesa JM, Duarte E, Cunillera O, et al. Efficacy of low-frequency low-intensity electrotherapy in the treatment of breast cancer-related lymphoedema: a cross-over randomized trial. Clin Rehabil. 2012;26(7):607–18.CrossRef Belmonte R, Tejero M, Ferrer M, Muniesa JM, Duarte E, Cunillera O, et al. Efficacy of low-frequency low-intensity electrotherapy in the treatment of breast cancer-related lymphoedema: a cross-over randomized trial. Clin Rehabil. 2012;26(7):607–18.CrossRef
21.
Zurück zum Zitat Bergmann A, Da Costa Leite Ferreira MG, De Aguiar SS, De Almeida Dias R, De Souza Abrahao K, Paltrinieri EM, et al. Physiotherapy in upper limb lymphedema after breast cancer treatment: a randomized study. Lymphology. 2014;47(2):82–91.PubMed Bergmann A, Da Costa Leite Ferreira MG, De Aguiar SS, De Almeida Dias R, De Souza Abrahao K, Paltrinieri EM, et al. Physiotherapy in upper limb lymphedema after breast cancer treatment: a randomized study. Lymphology. 2014;47(2):82–91.PubMed
22.
Zurück zum Zitat Gradalski T, Ochalek K, Kurpiewska J. Complex decongestive lymphatic therapy with or without vodder ii manual lymph drainage in more severe chronic postmastectomy upper limb lymphedema: a randomized noninferiority prospective study. J Pain Symptom Manag. 2015;50(6):750–7.CrossRef Gradalski T, Ochalek K, Kurpiewska J. Complex decongestive lymphatic therapy with or without vodder ii manual lymph drainage in more severe chronic postmastectomy upper limb lymphedema: a randomized noninferiority prospective study. J Pain Symptom Manag. 2015;50(6):750–7.CrossRef
24.
Zurück zum Zitat Johansson K, Lie E, Ekdahl C, Lindfeldt J. A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphedema. Lymphology. 1998;31(2):56–64.PubMed Johansson K, Lie E, Ekdahl C, Lindfeldt J. A randomized study comparing manual lymph drainage with sequential pneumatic compression for treatment of postoperative arm lymphedema. Lymphology. 1998;31(2):56–64.PubMed
25.
Zurück zum Zitat McNeely ML, Magee DJ, Lees AW, Bagnall KM, Haykowsky M, Hanson J. The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. 2004;86(2):95–106.CrossRef McNeely ML, Magee DJ, Lees AW, Bagnall KM, Haykowsky M, Hanson J. The addition of manual lymph drainage to compression therapy for breast cancer related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. 2004;86(2):95–106.CrossRef
26.
Zurück zum Zitat Odebiyi DO, Aborowa AT, Sokunbi OG, Aweto HA, Ajekigbe AT. Effects of exercise and oedema massage on fatigue level and quality of life of female breast cancer patients. Eur J Phys. 2014;16(4):238–45. Odebiyi DO, Aborowa AT, Sokunbi OG, Aweto HA, Ajekigbe AT. Effects of exercise and oedema massage on fatigue level and quality of life of female breast cancer patients. Eur J Phys. 2014;16(4):238–45.
27.
Zurück zum Zitat Ridner SH, Poage-Hooper E, Kanar C, Doersam JK, Bond SM, Dietrich MS. A pilot randomized trial evaluating low-level laser therapy as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema. Oncol Nurs Forum. 2013;40(4):383–93.CrossRef Ridner SH, Poage-Hooper E, Kanar C, Doersam JK, Bond SM, Dietrich MS. A pilot randomized trial evaluating low-level laser therapy as an alternative treatment to manual lymphatic drainage for breast cancer-related lymphedema. Oncol Nurs Forum. 2013;40(4):383–93.CrossRef
28.
Zurück zum Zitat Sanal-Toprak C, Ozsoy-Unubolo T, Bahar-Ozdemir Y, Akyuz G. The efficacy of intermittent pneumatic compression as a substitute for manual lymphatic drainage in complete decongestive therapy in the treatment of breast cancer related lymphedema. Lymphology. 2019;52(2):82–91.PubMed Sanal-Toprak C, Ozsoy-Unubolo T, Bahar-Ozdemir Y, Akyuz G. The efficacy of intermittent pneumatic compression as a substitute for manual lymphatic drainage in complete decongestive therapy in the treatment of breast cancer related lymphedema. Lymphology. 2019;52(2):82–91.PubMed
29.
Zurück zum Zitat Sitzia J, Sobrido L, Harlow W. Manual lymphatic drainage compared with simple lymphatic drainage in the treatment of post-mastectomy lymphoedema: a pilot randomised trial. Physiotherapy. 2002;88(2):99–107.CrossRef Sitzia J, Sobrido L, Harlow W. Manual lymphatic drainage compared with simple lymphatic drainage in the treatment of post-mastectomy lymphoedema: a pilot randomised trial. Physiotherapy. 2002;88(2):99–107.CrossRef
31.
Zurück zum Zitat Williams AF, Vadgama A, Franks PJ, Mortimer PS. A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. Eur J Cancer Care (Engl). 2002;11(4):254–61.CrossRef Williams AF, Vadgama A, Franks PJ, Mortimer PS. A randomized controlled crossover study of manual lymphatic drainage therapy in women with breast cancer-related lymphoedema. Eur J Cancer Care (Engl). 2002;11(4):254–61.CrossRef
32.
Zurück zum Zitat Cho Y, Do J, Jung S, Kwon O, Jeon J, Jeon JY. Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection. Support Care Cancer. 2016;24(5):2047–57.CrossRef Cho Y, Do J, Jung S, Kwon O, Jeon J, Jeon JY. Effects of a physical therapy program combined with manual lymphatic drainage on shoulder function, quality of life, lymphedema incidence, and pain in breast cancer patients with axillary web syndrome following axillary dissection. Support Care Cancer. 2016;24(5):2047–57.CrossRef
34.
Zurück zum Zitat Devoogdt N, Geraerts I, Van Kampen M, De Vrieze T, Vos L, Neven P, et al. Manual lymph drainage may not have a preventive effect on the development of breast cancer-related lymphoedema in the long term: a randomised trial. J Physiother. 2018;64(4):245–54.CrossRef Devoogdt N, Geraerts I, Van Kampen M, De Vrieze T, Vos L, Neven P, et al. Manual lymph drainage may not have a preventive effect on the development of breast cancer-related lymphoedema in the long term: a randomised trial. J Physiother. 2018;64(4):245–54.CrossRef
35.
Zurück zum Zitat Zimmermann A, Wozniewski M, Szklarska A, Lipowicz A, Szuba A. Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. Lymphology. 2012;45(3):103–12.PubMed Zimmermann A, Wozniewski M, Szklarska A, Lipowicz A, Szuba A. Efficacy of manual lymphatic drainage in preventing secondary lymphedema after breast cancer surgery. Lymphology. 2012;45(3):103–12.PubMed
36.
Zurück zum Zitat Abe R. A study on the pathogenesis of postmastectomy lymphedema. Tohoku J Exp Med. 1976;118(2):163–71.CrossRef Abe R. A study on the pathogenesis of postmastectomy lymphedema. Tohoku J Exp Med. 1976;118(2):163–71.CrossRef
38.
Zurück zum Zitat Földi M, Földi E, Strössenreuther RHK, Kubik S. Földi's textbook of lymphology : for physicians and lymphedema therapists. 2012. Földi M, Földi E, Strössenreuther RHK, Kubik S. Földi's textbook of lymphology : for physicians and lymphedema therapists. 2012.
39.
Zurück zum Zitat Yamamoto T, Todo Y, Kaneuchi M, Handa Y, Watanabe K, Yamamoto R. Study of edema reduction patterns during the treatment phase of complex decongestive physiotherapy for extremity lymphedema. Lymphology. 2008;41(2):80–6.PubMed Yamamoto T, Todo Y, Kaneuchi M, Handa Y, Watanabe K, Yamamoto R. Study of edema reduction patterns during the treatment phase of complex decongestive physiotherapy for extremity lymphedema. Lymphology. 2008;41(2):80–6.PubMed
40.
Zurück zum Zitat Mcduff SGR, Mina AI, Brunelle CL, Salama L, Warren LEG, Abouegylah M, et al. Timing of lymphedema after treatment for breast cancer: when are patients most at risk? Int J Radiat Oncol Biol Phys. 2019;103(1):62–70.CrossRef Mcduff SGR, Mina AI, Brunelle CL, Salama L, Warren LEG, Abouegylah M, et al. Timing of lymphedema after treatment for breast cancer: when are patients most at risk? Int J Radiat Oncol Biol Phys. 2019;103(1):62–70.CrossRef
41.
Zurück zum Zitat Karges JR, Mark BE, Stikeleather SJ, Worrell TW. Concurrent validity of upper-extremity volume estimates: comparison of calculated volume derived from girth measurements and water displacement volume. Phys Ther. 2003;83(2):134–45.CrossRef Karges JR, Mark BE, Stikeleather SJ, Worrell TW. Concurrent validity of upper-extremity volume estimates: comparison of calculated volume derived from girth measurements and water displacement volume. Phys Ther. 2003;83(2):134–45.CrossRef
42.
Zurück zum Zitat Sander AP, Hajer NM, Hemenway K, Miller AC. Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volume. Phys Ther. 2002;82(12):1201–12.CrossRef Sander AP, Hajer NM, Hemenway K, Miller AC. Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volume. Phys Ther. 2002;82(12):1201–12.CrossRef
43.
Zurück zum Zitat Stanton AW, Badger C, Sitzia J. Non-invasive assessment of the lymphedematous limb. Lymphology. 2000;33(3):122–35.PubMed Stanton AW, Badger C, Sitzia J. Non-invasive assessment of the lymphedematous limb. Lymphology. 2000;33(3):122–35.PubMed
44.
Zurück zum Zitat Sitzia J. Volume measurement in lymphoedema treatment: examination of formulae. Eur J Cancer Care (Engl). 1995;4(1):11–6.CrossRef Sitzia J. Volume measurement in lymphoedema treatment: examination of formulae. Eur J Cancer Care (Engl). 1995;4(1):11–6.CrossRef
45.
Zurück zum Zitat Deltombe T, Jamart J, Recloux S, Legrand C, Vandenbroeck N, Theys S, et al. Reliability and limits of agreement of circumferential, water displacement, and optoelectronic volumetry in the measurement of upper limb lymphedema. Lymphology. 2007;40(1):26–34.PubMed Deltombe T, Jamart J, Recloux S, Legrand C, Vandenbroeck N, Theys S, et al. Reliability and limits of agreement of circumferential, water displacement, and optoelectronic volumetry in the measurement of upper limb lymphedema. Lymphology. 2007;40(1):26–34.PubMed
Metadaten
Titel
Manual lymphatic drainage treatment for lymphedema: a systematic review of the literature
verfasst von
Belinda Thompson
Katrina Gaitatzis
Xanne Janse de Jonge
Robbie Blackwell
Louise A. Koelmeyer
Publikationsdatum
15.08.2020
Verlag
Springer US
Erschienen in
Journal of Cancer Survivorship / Ausgabe 2/2021
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI
https://doi.org/10.1007/s11764-020-00928-1

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