Mapping brain volume change across time in primary-progressive multiple sclerosis
- 13.04.2024
- Advanced Neuroimaging
Erschienen in:
- Verfasst von
- Yehuda Warszawer
- Michael Gurevich
- Ariel Kerpel
- Sapir Dreyer Alster
- Yael Nissan
- Emanuel Shirbint
- Chen Hoffmann
- Anat Achiron
- Erschienen in
- Neuroradiology | Ausgabe 7/2024
Abstract
Purpose
Detection and prediction of the rate of brain volume loss with age is a significant unmet need in patients with primary progressive multiple sclerosis (PPMS). In this study we construct detailed brain volume maps for PPMS patients. These maps compare age-related changes in both cortical and sub-cortical regions with those in healthy individuals.
Methods
We conducted retrospective analyses of brain volume using T1-weighted Magnetic Resonance Imaging (MRI) scans of a large cohort of PPMS patients and healthy subjects. The volume of brain parenchyma (BP), cortex, white matter (WM), deep gray matter, thalamus, and cerebellum were measured using the robust SynthSeg segmentation tool. Age- and gender-related regression curves were constructed based on data from healthy subjects, with the 95% prediction interval adopted as the normality threshold for each brain region.
Results
We analyzed 495 MRI scans from 169 PPMS patients, aged 20–79 years, alongside 563 exams from healthy subjects aged 20–86. Compared to healthy subjects, a higher proportion of PPMS patients showed lower than expected brain volumes in all regions except the cerebellum. The most affected areas were BP, WM, and thalamus. Lower brain volumes correlated with longer disease duration for BP and WM, and higher disability for BP, WM, cortex, and thalamus.
Conclusions
Constructing age- and gender-related brain volume maps enabled identifying PPMS patients at a higher risk of brain volume loss. Monitoring these high-risk patients may lead to better treatment decisions and improve patient outcomes.
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- Titel
- Mapping brain volume change across time in primary-progressive multiple sclerosis
- Verfasst von
-
Yehuda Warszawer
Michael Gurevich
Ariel Kerpel
Sapir Dreyer Alster
Yael Nissan
Emanuel Shirbint
Chen Hoffmann
Anat Achiron
- Publikationsdatum
- 13.04.2024
- Verlag
- Springer Berlin Heidelberg
- Erschienen in
-
Neuroradiology / Ausgabe 7/2024
Print ISSN: 0028-3940
Elektronische ISSN: 1432-1920 - DOI
- https://doi.org/10.1007/s00234-024-03354-7
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