Skip to main content
main-content

01.10.2010 | Breast Oncology | Ausgabe 10/2010

Annals of Surgical Oncology 10/2010

Margin Index: A New Method for Prediction of Residual Disease After Breast-Conserving Surgery

Zeitschrift:
Annals of Surgical Oncology > Ausgabe 10/2010
Autoren:
MD Julie A. Margenthaler, PhD Feng Gao, MD V. Suzanne Klimberg

Abstract

Background

We hypothesized that the optimum margin after breast-conserving therapy (BCT) should depend on the original size of the tumor. We propose that “margin index”—a relationship of the margin obtained to the size of the tumor—is a better predictor of residual disease on reexcision than margin alone.

Methods

We identified 475 consecutive patients with Stage I-II breast cancer, with or without ductal carcinoma in situ, who were treated with BCT from 1998–2008 who also underwent reexcision for close margins. Margin index was calculated as follows: margin index = closest margin (mm)/tumor size (mm) × 100. A receiver operating curve was created using the derived margin index and the presence or absence of residual disease in the reexcision specimen. Sensitivity and specificity were calculated at various margin indices to determine the optimum margin index.

Results

Of the 475 patients, 102 (21%) had residual disease in the reexcision specimen. The optimum margin index was >5; the risk of residual disease for a margin index >5 was only 3.2%. The sensitivity and specificity of a margin index cutoff of 5 was 85 and 73%, respectively. The overall c index for the receiver operating curve was 0.88. The margin index was the only factor predictive of residual disease in multivariate analysis.

Conclusions

Margin index is a reliable method for the prediction of residual disease after attempted BCT with close margins. This simple calculation may be helpful for identifying patients who require reexcision before radiation therapy and those who may be able to forego additional surgical interventions.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Jetzt bestellen und 50 € OTTO-Gutschein sichern!

Weitere Produktempfehlungen anzeigen
Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 10/2010

Annals of Surgical Oncology 10/2010 Zur Ausgabe
  1. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

  2. Das kostenlose Testabonnement läuft nach 14 Tagen automatisch und formlos aus. Dieses Abonnement kann nur einmal getestet werden.

Neu im Fachgebiet Chirurgie


 

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Chirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise