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Erschienen in: Pathology & Oncology Research 4/2017

19.01.2017 | Original Article

Marked Differences of Haplotype Tagging SNP Distribution, Linkage, and Haplotype Profile of APOA5 Gene in Roma Population Samples

verfasst von: Katalin Sumegi, Balazs Duga, Bela I. Melegh, Zsolt Banfai, Erzsebet Kovesdi, Anita Maasz, Bela Melegh

Erschienen in: Pathology & Oncology Research | Ausgabe 4/2017

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Abstract

Roma people are underprivileged, neglected population worldwide, with severe healthcare problems. They have significantly increased prevalence of cardiovascular morbidity, presumably related to their poor social status, alcohol consumption and smoking habits. Assuming that genetic background also plays a role in their susceptibility for cardiovascular diseases, we hypothesized that APOA5 gene polymorphisms, an important role-player in lipid metabolism and in the development of metabolic syndrome and cardio/cerebrovascular events, may also be involved. We examined four APOA5 polymorphisms in 363 Roma and 404 Hungarian DNA samples. For rs662799, rs2266788, rs207560 and rs3135506 we found elevated plasma triglyceride levels in the risk allele carriers compared to non-carriers in both populations. At least a two-fold significant increase was detected in minor allele frequencies in Roma when compared to Hungarians, except the rs2266788 variant. Haplotype analysis revealed significant increase of APOA5*2, APOA5*4 in Roma, as opposed to the higher levels of APOA5*5 found in Hungarians. Different linkage disequilibrium was found between rs207560 and rs3135506 variants in Roma compared to Hungarians. The profound differences observed in almost all APOA5 polymorphisms in Roma require special attention, since these variants are known to associate with cardio/cerebrovascular susceptibility.
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Metadaten
Titel
Marked Differences of Haplotype Tagging SNP Distribution, Linkage, and Haplotype Profile of APOA5 Gene in Roma Population Samples
verfasst von
Katalin Sumegi
Balazs Duga
Bela I. Melegh
Zsolt Banfai
Erzsebet Kovesdi
Anita Maasz
Bela Melegh
Publikationsdatum
19.01.2017
Verlag
Springer Netherlands
Erschienen in
Pathology & Oncology Research / Ausgabe 4/2017
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI
https://doi.org/10.1007/s12253-017-0197-3

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