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01.01.2021 | Basic and Applied Science (I Lewkowich, Section Editor) | Ausgabe 1/2021

Current Allergy and Asthma Reports 1/2021

Mast Cell-Specific MRGPRX2: a Key Modulator of Neuro-Immune Interaction in Allergic Diseases

Zeitschrift:
Current Allergy and Asthma Reports > Ausgabe 1/2021
Autoren:
Monica Thapaliya, Chalatip Chompunud Na Ayudhya, Aetas Amponnawarat, Saptarshi Roy, Hydar Ali
Wichtige Hinweise
This article is part of the Topical Collection on Basic and Applied Science

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Abstract

Purpose of Review

Atopic dermatitis (AD) and allergic asthma are complex disorders with significant public health burden. This review provides an overview of the recent developments on Mas-related G protein-coupled receptor-X2 (MRGPRX2; mouse counterpart MrgprB2) as a potential candidate to target neuro-immune interaction in AD and allergic asthma.

Recent Findings

Domestic allergens directly activate sensory neurons to release substance P (SP), which induces mast cell degranulation via MrgprB2 and drives type 2 skin inflammation in AD. MRGPRX2 expression is upregulated in human lung mast cells and serum of asthmatic patients. Both SP and hemokinin-1 (HK-1 generated from macrophages, bronchial cells, and mast cells) cause degranulation of human mast cells via MRGPRX2.

Summary

MrgprB2 contributes to mast cell-nerve interaction in the pathogenesis of AD. Furthermore, asthma severity is associated with increased MRGPRX2 expression in mast cells. Thus, MRGPRX2 could serve as a novel target for modulating AD and asthma.

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Literatur
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