Erschienen in:
01.05.2010 | Original paper
Maternal hormones during early pregnancy: a cross-sectional study
verfasst von:
Tianhui Chen, Eva Lundin, Kjell Grankvist, Anne Zeleniuch-Jacquotte, Marianne Wulff, Yelena Afanasyeva, Helena Schock, Robert Johansson, Per Lenner, Goran Hallmans, Goran Wadell, Paolo Toniolo, Annekatrin Lukanova
Erschienen in:
Cancer Causes & Control
|
Ausgabe 5/2010
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Abstract
Background
Little is known about correlates of first-trimester pregnancy hormones as in most studies maternal hormones have been measured later in gestation. We examined the associations of maternal characteristics and child sex with first-trimester maternal concentrations of four hormones implicated in breast cancer: human chorionic gonadotropin (hCG), α-fetoprotein (AFP), insulin-like growth factor (IGF)-I, and IGF-II.
Methods
About 338 serum samples donated to the Northern Sweden Maternity Cohort (NSMC), 1975–2001, during the first trimester of uncomplicated pregnancies, were analyzed for the hormones of interest as a part of a case–control study. The associations of maternal characteristics and child sex with hormone concentrations were investigated by correlation, general linear regression, and multivariate regression models.
Results
In the first trimester, greater maternal age was inversely correlated with IGF-I and IGF-II. In comparison with women carrying their first child, already parous women had higher IGF-I but lower hCG. Greater maternal weight and smoking were inversely correlated with hCG. No differences in hormone levels by child sex were observed.
Conclusions
Our analyses indicated that potentially modifiable maternal characteristics (maternal weight and smoking) influence first-trimester pregnancy maternal hormone concentrations.