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Archives of Gynecology and Obstetrics

Erschienen in:

04.11.2017 | Review

Maternal sepsis in the era of genomic medicine

verfasst von: C. Kouskouti, N. Evangelatos, A. Brand, F. Kainer

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 1/2018

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Abstract

Purpose

Maternal sepsis remains one of the leading causes of direct and indirect maternal mortality both in high- and low-income environments. In the last two decades, systems biology approaches, based on ‘-omics’ technologies, have started revolutionizing the diagnosis and management of the septic syndrome. The scope of this narrative review is to present an overview of the basic ‘-omics’ technologies, exemplified by cases relevant to maternal sepsis.

Methods

Narrative review of the new ‘-omics’ technologies based on a detailed review of the literature.

Results

After presenting the main ‘omics’ technologies, we discuss their limitations and the need for integrated approaches that encompass research efforts across multiple ‘-omics’ layers in the ‘-omics’ cascade between the genome and the phenome.

Conclusions

Systems biology approaches are revolutionizing the research landscape in maternal sepsis. There is a need for increased awareness, from the side of health practitioners, as a requirement for the effective implementation of the new technologies in the research and clinical practice in maternal sepsis.

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Titel: Maternal sepsis in the era of genomic medicine
verfasst von: C. Kouskouti
N. Evangelatos
A. Brand
F. Kainer
Publikationsdatum: 04.11.2017
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 1/2018
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-017-4584-5

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Springer Medizin

Maternal sepsis in the era of genomic medicine

Abstract

Purpose

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Conclusions

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ICI-Therapie in der Schwangerschaft wird gut toleriert

Weniger postpartale Depressionen nach Esketamin-Einmalgabe

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Harnwegsinfektprophylaxe: Es geht auch ohne Antibiotika

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Springer Medizin

Abstract

Purpose

Methods

Results

Conclusions

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