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19.12.2018 | Symposium-in-Writing Paper

MDSCs in infectious diseases: regulation, roles, and readjustment

verfasst von: Anca Dorhoi, Estibaliz Glaría, Thalia Garcia-Tellez, Natalie E. Nieuwenhuizen, Gennadiy Zelinskyy, Benoit Favier, Anurag Singh, Jan Ehrchen, Cornelia Gujer, Christian Münz, Margarida Saraiva, Yahya Sohrabi, Ana E. Sousa, Peter Delputte, Michaela Müller-Trutwin, Annabel F. Valledor

Erschienen in: Cancer Immunology, Immunotherapy | Ausgabe 4/2019

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Abstract

Many pathogens, ranging from viruses to multicellular parasites, promote expansion of MDSCs, which are myeloid cells that exhibit immunosuppressive features. The roles of MDSCs in infection depend on the class and virulence mechanisms of the pathogen, the stage of the disease, and the pathology associated with the infection. This work compiles evidence supported by functional assays on the roles of different subsets of MDSCs in acute and chronic infections, including pathogen-associated malignancies, and discusses strategies to modulate MDSC dynamics to benefit the host.

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Titel: MDSCs in infectious diseases: regulation, roles, and readjustment
verfasst von: Anca Dorhoi
Estibaliz Glaría
Thalia Garcia-Tellez
Natalie E. Nieuwenhuizen
Gennadiy Zelinskyy
Benoit Favier
Anurag Singh
Jan Ehrchen
Cornelia Gujer
Christian Münz
Margarida Saraiva
Yahya Sohrabi
Ana E. Sousa
Peter Delputte
Michaela Müller-Trutwin
Annabel F. Valledor
Publikationsdatum: 19.12.2018
Verlag: Springer Berlin Heidelberg
Erschienen in: Cancer Immunology, Immunotherapy / Ausgabe 4/2019
Print ISSN: 0340-7004
Elektronische ISSN: 1432-0851
DOI: https://doi.org/10.1007/s00262-018-2277-y

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23.04.2024 | Medikamente in Schwangerschaft und Stillzeit | Nachrichten

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

MDSCs in infectious diseases: regulation, roles, and readjustment

Abstract

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Springer Medizin

Abstract

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Weitere Artikel der Ausgabe 4/2019

Role of myeloid regulatory cells (MRCs) in maintaining tissue homeostasis and promoting tolerance in autoimmunity, inflammatory disease and transplantation

Strong antigen-specific T-cell immunity induced by a recombinant human TERT measles virus vaccine and amplified by a DNA/viral vector prime boost in IFNAR/CD46 mice

Acknowledgements

A potential role for peripheral natural killer cell activity induced by preoperative chemotherapy in breast cancer patients

A pilot study of interferon-alpha-2b dose reduction in the adjuvant therapy of high-risk melanoma

Deciphering myeloid-derived suppressor cells: isolation and markers in humans, mice and non-human primates

Neu im Fachgebiet Onkologie

ICI-Therapie in der Schwangerschaft wird gut toleriert

Krebspatienten impfen: Was? Wen? Und wann nicht?

Müde im Alter? Auch an die Nebenniere denken

Stufenschema weist Prostatakarzinom zuverlässig nach

Update Onkologie