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06.06.2019 | Spleen

Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise

verfasst von: Cheng William Hong, Gavin Hamilton, Catherine Hooker, Charlie C. Park, Calvin Andrew Tran, Walter C. Henderson, Jonathan C. Hooker, Soudabeh Fazeli Dehkordy, Jeffrey B. Schwimmer, Scott B. Reeder, Claude B. Sirlin

Erschienen in: Abdominal Radiology | Ausgabe 10/2019

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Abstract

Purpose

This study compares splenic proton density fat fraction (PDFF) measured using confounder-corrected chemical shift-encoded (CSE)-MRI to magnetic resonance spectroscopy (MRS) in human patients at 3T.

Methods

This was a prospectively designed ancillary study to various previously described single-center studies performed in adults and children with known or suspected nonalcoholic fatty liver disease. Patients underwent magnitude-based MRI (MRI-M), complex-based MRI (MRI-C), high signal-to-noise variants (Hi-SNR MRI-M and Hi-SNR MRI-C), and MRS at 3T for spleen PDFF estimation. PDFF from CSE-MRI methods were compared to MRS-PDFF using Wilcoxon signed-rank tests. Demographics were summarized descriptively. Spearman’s rank correlations were computed pairwise between CSE-MRI methods. Individual patient measurements were plotted for qualitative assessment. A significance level of 0.05 was used.

Results

Forty-seven patients (20 female, 27 male) including 12 adults (median 55 years old) and 35 children (median 12 years old). Median PDFF estimated by MRS, MRI-M, Hi-SNR MRI-M, MRI-C, and Hi-SNR MRI-C was 1.0, 2.3, 1.9, 2.2, and 2.0%. The four CSE-MRI methods estimated statistically significant higher spleen PDFF values compared to MRS (p < 0.0001 for all). Pairwise associations in spleen PDFF values measured by different CSE-MRI methods were weak, with the highest Spearman’s rank correlations being 0.295 between MRI-M and Hi-SNR MRI-M; none were significant after correction for multiple comparisons. No qualitative relationship was observed between PDFF measurements among the various methods.

Conclusion

Overestimation of PDFF by CSE-MRI compared to MRS and poor agreement between related CSE-MRI methods suggest that non-zero PDFF values in human spleen are artifactual.

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Titel: Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise
verfasst von: Cheng William Hong
Gavin Hamilton
Catherine Hooker
Charlie C. Park
Calvin Andrew Tran
Walter C. Henderson
Jonathan C. Hooker
Soudabeh Fazeli Dehkordy
Jeffrey B. Schwimmer
Scott B. Reeder
Claude B. Sirlin
Publikationsdatum: 06.06.2019
Verlag: Springer US
Erschienen in: Abdominal Radiology / Ausgabe 10/2019
Print ISSN: 2366-004X
Elektronische ISSN: 2366-0058
DOI: https://doi.org/10.1007/s00261-019-02079-z

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Measurement of spleen fat on MRI-proton density fat fraction arises from reconstruction of noise

Abstract

Purpose

Methods

Results

Conclusion

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Abstract

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