Background
Objective
Methods
Criteria for considering studies for review:
Type of studies
Participants
Index models (prediction models for clinical outcomes being evaluated in this review) [13]
Target conditions for predicting mortality
Reference standards to confirm mortality
Data sources and search strategy
Data collection
Selection of studies
Data extraction
Assessment of methodological quality
Search for measurement properties of identified comorbidity indices
Results
Description of included study and indices
Study | Year | Design | n | Comorbidity Index | Outcome | C-statistic (95% CI) |
---|---|---|---|---|---|---|
Bateman et al. [27] | 2013 | Retrospective Cohort | 854,823 | The maternal comorbidity index | Organ injury or death | 0.657 (0.647–0.666) |
The Charlson comorbidity index | Organ injury or death | 0.578 (0.570–0.585) | ||||
The Elixhauser comorbidity Index | Organ injury or death | 0.586 (0.575–0.597) | ||||
Metcalfe et al. [28] | 2015 | Retrospective Cohort | 5995 | The maternal comorbidity index | Organ injury | 0.67 (0.58–0.76) |
Methodological quality
Studies for measurement properties
Discussion
Maternal Comorbidity Index | Charlson Comorbidity Index | Elixhauser Comorbidity Index | |
---|---|---|---|
Development
| |||
Item generation | Based on clinical relevance and literature, but no consensus method applied | No input from previous index, and no consensus method applied | Based on review of published studies, but no consensus method applied |
Item reduction | Odds ratio and p-value from statistical model applied | Adjusted relative risk from statistical model applied, but no clinical relevance for pregnant population | A series of univariable and multivariable regression models |
Item weighting | Weights of coefficients from statistical model used | Weights of coefficients from statistical model used | No weighting |
Sensibility
| |||
Purpose | Predict end-organ injury or death during the delivery hospitalization to 30 days | Predict 1-year mortality | In-hospital mortality |
Population | Women who delivered in hospital | General medical patients | Adult, non-maternal inpatients |
Setting | Hospitals in U.S. | Medical ward in a hospital | Hospitals in California |
Face validity | Exists | Exists | Exists |
Content validity | Reasonable | Challenging | Reasonable |
Feasibility | No study | Marked training required | No study |
Reliability
| Not studied | Excellent in general No maternal studies | Not studied |
Criterion validity
| |||
Concurrent validity | Not studied | No maternal studies | No maternal studies |