Skip to main content
Erschienen in: Current Heart Failure Reports 3/2012

01.09.2012 | Decompensated Heart Failure (MM Givertz, Section editor)

Mechanical Circulatory Support in Children: Bridge to Transplant Versus Recovery

verfasst von: John L. Jefferies, David L. Morales

Erschienen in: Current Heart Failure Reports | Ausgabe 3/2012

Einloggen, um Zugang zu erhalten

Abstract

The number of children and adolescents suffering from heart failure is increasing dramatically. Some of these patients will progress to need advanced therapies in the form of mechanical circulatory support (MCS). Over the past few years, increased attention has been focused on clinical use of existing devices as well the development of pediatric-specific ventricular assist devices (VADs). As in adult populations, these devices offer unique opportunities to successfully support children as a bridge-to-transplant, but increasing data suggest that bridge-to-recovery and bridge-to-destination are also viable options in select pediatric populations. Herein, we will review existing approaches as well describe future potential MCS options.
Literatur
1.
Zurück zum Zitat Rossano JW, Kim JJ, Decker JA, et al. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail. 2012;18:459–70.PubMedCrossRef Rossano JW, Kim JJ, Decker JA, et al. Prevalence, morbidity, and mortality of heart failure-related hospitalizations in children in the United States: a population-based study. J Card Fail. 2012;18:459–70.PubMedCrossRef
2.
Zurück zum Zitat Gibbon Jr JH. Application of a mechanical heart and lung apparatus to cardiac surgery. Minn Med. 1954;37:171–85. passim.PubMed Gibbon Jr JH. Application of a mechanical heart and lung apparatus to cardiac surgery. Minn Med. 1954;37:171–85. passim.PubMed
3.
Zurück zum Zitat Liotta D, Hall CW, Henly WS, Cooley DA, Crawford ES, Debakey ME. Prolonged assisted circulation during and after cardiac or aortic surgery. Prolonged partial left ventricular bypass by means of intracorporeal circulation. Am J Cardiol. 1963;12:399–405.PubMedCrossRef Liotta D, Hall CW, Henly WS, Cooley DA, Crawford ES, Debakey ME. Prolonged assisted circulation during and after cardiac or aortic surgery. Prolonged partial left ventricular bypass by means of intracorporeal circulation. Am J Cardiol. 1963;12:399–405.PubMedCrossRef
4.
Zurück zum Zitat Cooley DA, Liotta D, Hallman GL, Bloodwell RD, Leachman RD, Milam JD. Orthotopic cardiac prosthesis for two-staged cardiac replacement. Am J Cardiol. 1969;24:723–30.PubMedCrossRef Cooley DA, Liotta D, Hallman GL, Bloodwell RD, Leachman RD, Milam JD. Orthotopic cardiac prosthesis for two-staged cardiac replacement. Am J Cardiol. 1969;24:723–30.PubMedCrossRef
5.
Zurück zum Zitat Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345:1435–43.PubMedCrossRef Rose EA, Gelijns AC, Moskowitz AJ, et al. Long-term use of a left ventricular assist device for end-stage heart failure. N Engl J Med. 2001;345:1435–43.PubMedCrossRef
6.
Zurück zum Zitat Kirklin JK, Naftel DC, Kormos RL, et al. Third INTERMACS annual report: the evolution of destination therapy in the United States. J Heart Lung Transplant. 2011;30:115–23.PubMedCrossRef Kirklin JK, Naftel DC, Kormos RL, et al. Third INTERMACS annual report: the evolution of destination therapy in the United States. J Heart Lung Transplant. 2011;30:115–23.PubMedCrossRef
7.
Zurück zum Zitat Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010;6:559-73, x. Jefferies JL, Price JF, Morales DL. Mechanical support in childhood heart failure. Heart Fail Clin. 2010;6:559-73, x.
8.
Zurück zum Zitat • Cabrera AG, Sundareswaran K, Samayoa AX, Farrar DJ, Frazier OH, Morales DL. Outcomes of pediatric patients supported by the Heartmate II LVAD in the USA. J Heart Lung Transplant 2012;31:S121. This analysis documents the increasing use of the HeartMate II device in children but also underscores that the management of pediatric patients may present a different set of challenges. • Cabrera AG, Sundareswaran K, Samayoa AX, Farrar DJ, Frazier OH, Morales DL. Outcomes of pediatric patients supported by the Heartmate II LVAD in the USA. J Heart Lung Transplant 2012;31:S121. This analysis documents the increasing use of the HeartMate II device in children but also underscores that the management of pediatric patients may present a different set of challenges.
9.
Zurück zum Zitat • Miera O, Potapov EV, Redlin M, et al. First experiences with the HeartWare ventricular assist system in children. Ann Thorac Surg. 2011;91:1256-60. This report heralds expansion of next-generation devices from exclusive use in adults into the pediatric realm. Application of existing adult technologies adds to the pediatric HF treatment armamentarium but further emphasizes the need for careful patient selection. • Miera O, Potapov EV, Redlin M, et al. First experiences with the HeartWare ventricular assist system in children. Ann Thorac Surg. 2011;91:1256-60. This report heralds expansion of next-generation devices from exclusive use in adults into the pediatric realm. Application of existing adult technologies adds to the pediatric HF treatment armamentarium but further emphasizes the need for careful patient selection.
10.
Zurück zum Zitat Fiser WP, Yetman AT, Gunselman RJ, et al. Pediatric arteriovenous extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation. J Heart Lung Transplant. 2003;22:770–7.PubMedCrossRef Fiser WP, Yetman AT, Gunselman RJ, et al. Pediatric arteriovenous extracorporeal membrane oxygenation (ECMO) as a bridge to cardiac transplantation. J Heart Lung Transplant. 2003;22:770–7.PubMedCrossRef
11.
Zurück zum Zitat Gajarski RJ, Mosca RS, Ohye RG, et al. Use of extracorporeal life support as a bridge to pediatric cardiac transplantation. J Heart Lung Transplant. 2003;22:28–34.PubMedCrossRef Gajarski RJ, Mosca RS, Ohye RG, et al. Use of extracorporeal life support as a bridge to pediatric cardiac transplantation. J Heart Lung Transplant. 2003;22:28–34.PubMedCrossRef
12.
Zurück zum Zitat Stiller B, Hetzer R, Weng Y, et al. Heart transplantation in children after mechanical circulatory support with pulsatile pneumatic assist device. J Heart Lung Transplant. 2003;22:1201–8.PubMedCrossRef Stiller B, Hetzer R, Weng Y, et al. Heart transplantation in children after mechanical circulatory support with pulsatile pneumatic assist device. J Heart Lung Transplant. 2003;22:1201–8.PubMedCrossRef
13.
Zurück zum Zitat Ishino K, Loebe M, Uhlemann F, Weng Y, Hennig E, Hetzer R. Circulatory support with paracorporeal pneumatic ventricular assist device (VAD) in infants and children. European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery. 1997;11:965–72.CrossRef Ishino K, Loebe M, Uhlemann F, Weng Y, Hennig E, Hetzer R. Circulatory support with paracorporeal pneumatic ventricular assist device (VAD) in infants and children. European journal of cardio-thoracic surgery: official journal of the European Association for Cardio-thoracic Surgery. 1997;11:965–72.CrossRef
14.
Zurück zum Zitat del Nido PJ, Dalton HJ, Thompson AE, Siewers RD. Extracorporeal membrane oxygenator rescue in children during cardiac arrest after cardiac surgery. Circulation. 1992;86:II300-4. del Nido PJ, Dalton HJ, Thompson AE, Siewers RD. Extracorporeal membrane oxygenator rescue in children during cardiac arrest after cardiac surgery. Circulation. 1992;86:II300-4.
15.
Zurück zum Zitat Duncan BW, Ibrahim AE, Hraska V, et al. Use of rapid-deployment extracorporeal membrane oxygenation for the resuscitation of pediatric patients with heart disease after cardiac arrest. J Thorac Cardiovasc Surg. 1998;116:305–11.PubMedCrossRef Duncan BW, Ibrahim AE, Hraska V, et al. Use of rapid-deployment extracorporeal membrane oxygenation for the resuscitation of pediatric patients with heart disease after cardiac arrest. J Thorac Cardiovasc Surg. 1998;116:305–11.PubMedCrossRef
16.
Zurück zum Zitat • Lowry AW, Adachi I, Gregoric ID, Jeewa A, Morales DL. The potential to avoid heart transplantation in children: outpatient bridge to recovery with an intracorporeal continuous-flow left ventricular assist device in a 14-year-old. Congenital heart disease 2012. An important management strategy is defined with this report of recovery in a 14-year-old patient. Pediatric patients must be assessed for evidence of durable myocardial recovery and, with this, possibly avoid need for transplant. • Lowry AW, Adachi I, Gregoric ID, Jeewa A, Morales DL. The potential to avoid heart transplantation in children: outpatient bridge to recovery with an intracorporeal continuous-flow left ventricular assist device in a 14-year-old. Congenital heart disease 2012. An important management strategy is defined with this report of recovery in a 14-year-old patient. Pediatric patients must be assessed for evidence of durable myocardial recovery and, with this, possibly avoid need for transplant.
17.
Zurück zum Zitat Shamszad P, Cabrera AG, Kim JJ, et al. Perioperative atrial tachycardia is associated with increased mortality in infants undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2012. Shamszad P, Cabrera AG, Kim JJ, et al. Perioperative atrial tachycardia is associated with increased mortality in infants undergoing cardiac surgery. J Thorac Cardiovasc Surg. 2012.
18.
Zurück zum Zitat •• Almond CS, Buchholz H, Massicotte P, et al. Berlin Heart EXCOR Pediatric ventricular assist device Investigational Device Exemption study: study design and rationale. Am Heart J. 2011;162:425-35 e6. This landmark study resulted in FDA approval of a pediatric-specific device. This will function as the precedent for future pediatric MCS investigation. •• Almond CS, Buchholz H, Massicotte P, et al. Berlin Heart EXCOR Pediatric ventricular assist device Investigational Device Exemption study: study design and rationale. Am Heart J. 2011;162:425-35 e6. This landmark study resulted in FDA approval of a pediatric-specific device. This will function as the precedent for future pediatric MCS investigation.
19.
Zurück zum Zitat Maskatia SA, Decker JA, Spinner JA, et al. Restrictive physiology is associated with poor outcomes in children with hypertrophic cardiomyopathy. Pediatr Cardiol. 2012;33:141–9.PubMedCrossRef Maskatia SA, Decker JA, Spinner JA, et al. Restrictive physiology is associated with poor outcomes in children with hypertrophic cardiomyopathy. Pediatr Cardiol. 2012;33:141–9.PubMedCrossRef
20.
Zurück zum Zitat Wilson SR, Givertz MM, Stewart GC, Mudge Jr GH. Ventricular assist devices the challenges of outpatient management. J Am Coll Cardiol. 2009;54:1647–59.PubMedCrossRef Wilson SR, Givertz MM, Stewart GC, Mudge Jr GH. Ventricular assist devices the challenges of outpatient management. J Am Coll Cardiol. 2009;54:1647–59.PubMedCrossRef
21.
Zurück zum Zitat Miller LW, Pagani FD, Russell SD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885–96.PubMedCrossRef Miller LW, Pagani FD, Russell SD, et al. Use of a continuous-flow device in patients awaiting heart transplantation. N Engl J Med. 2007;357:885–96.PubMedCrossRef
22.
Zurück zum Zitat Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241–51.PubMedCrossRef Slaughter MS, Rogers JG, Milano CA, et al. Advanced heart failure treated with continuous-flow left ventricular assist device. N Engl J Med. 2009;361:2241–51.PubMedCrossRef
23.
Zurück zum Zitat Bellinger DC, Wypij D, Kuban KC, et al. Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation. 1999;100:526–32.PubMedCrossRef Bellinger DC, Wypij D, Kuban KC, et al. Developmental and neurological status of children at 4 years of age after heart surgery with hypothermic circulatory arrest or low-flow cardiopulmonary bypass. Circulation. 1999;100:526–32.PubMedCrossRef
24.
Zurück zum Zitat Hovels-Gurich HH, Bauer SB, Schnitker R, et al. Long-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy. European journal of paediatric neurology: EJPN: official journal of the European Paediatric Neurology Society. 2008;12:378–86. Hovels-Gurich HH, Bauer SB, Schnitker R, et al. Long-term outcome of speech and language in children after corrective surgery for cyanotic or acyanotic cardiac defects in infancy. European journal of paediatric neurology: EJPN: official journal of the European Paediatric Neurology Society. 2008;12:378–86.
25.
Zurück zum Zitat Goldstein DJ, Oz MC, Rose EA. Implantable left ventricular assist devices. N Engl J Med. 1998;339:1522–33.PubMedCrossRef Goldstein DJ, Oz MC, Rose EA. Implantable left ventricular assist devices. N Engl J Med. 1998;339:1522–33.PubMedCrossRef
26.
Zurück zum Zitat Petrucci RJ, Wright S, Naka Y, et al. Neurocognitive assessments in advanced heart failure patients receiving continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2009;28:542–9.PubMedCrossRef Petrucci RJ, Wright S, Naka Y, et al. Neurocognitive assessments in advanced heart failure patients receiving continuous-flow left ventricular assist devices. J Heart Lung Transplant. 2009;28:542–9.PubMedCrossRef
27.
Zurück zum Zitat • Stein ML, Bruno JL, Konopacki KL, Kesler S, Reinhartz O, Rosenthal DN. Cognitive outcomes in pediatric VAD and transplant recipients: A pilot study. J Heart Lung Transplant. 2012;31:S119. Different diagnostic and management strategies will be required to manage pediatric neurodevelopmental issues associated with MCS. • Stein ML, Bruno JL, Konopacki KL, Kesler S, Reinhartz O, Rosenthal DN. Cognitive outcomes in pediatric VAD and transplant recipients: A pilot study. J Heart Lung Transplant. 2012;31:S119. Different diagnostic and management strategies will be required to manage pediatric neurodevelopmental issues associated with MCS.
28.
Zurück zum Zitat • Samayoa AX, Moffett BS, Khan MS, Mery CM, Heinle JS, Morales DL. Hospital costs for supporting children with ventricular assist device in the United States. J Heart Lung Transplant. 2012;31:S119. With increasing focus on cost in pediatric populations, an attempt at defining the current costs in care is critical to process improvement. • Samayoa AX, Moffett BS, Khan MS, Mery CM, Heinle JS, Morales DL. Hospital costs for supporting children with ventricular assist device in the United States. J Heart Lung Transplant. 2012;31:S119. With increasing focus on cost in pediatric populations, an attempt at defining the current costs in care is critical to process improvement.
29.
Zurück zum Zitat • Morales DL, Adachi I, Heinle JS, Fraser CD, Jr. A new era: use of an intracorporeal systemic ventricular assist device to support a patient with a failing Fontan circulation. J Thorac Cardiovasc Surg. 2011;142:e138-40. The traditional approach to MCS in children has been directed at biventricular circulations. The ability to successfully support single ventricle patients will address a growing area of need. • Morales DL, Adachi I, Heinle JS, Fraser CD, Jr. A new era: use of an intracorporeal systemic ventricular assist device to support a patient with a failing Fontan circulation. J Thorac Cardiovasc Surg. 2011;142:e138-40. The traditional approach to MCS in children has been directed at biventricular circulations. The ability to successfully support single ventricle patients will address a growing area of need.
Metadaten
Titel
Mechanical Circulatory Support in Children: Bridge to Transplant Versus Recovery
verfasst von
John L. Jefferies
David L. Morales
Publikationsdatum
01.09.2012
Verlag
Current Science Inc.
Erschienen in
Current Heart Failure Reports / Ausgabe 3/2012
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-012-0103-y

Weitere Artikel der Ausgabe 3/2012

Current Heart Failure Reports 3/2012 Zur Ausgabe

Decompensated Heart Failure (MM Givertz, Section editor)

Diuretic Dosing in Acute Decompensated Heart Failure: Lessons from DOSE

Decompensated Heart Failure (MM Givertz, Section editor)

Management of Acute Right Ventricular Failure in the Intensive Care Unit

Investigative Therapies (J.-L. Balligand, Section editor)

16-kDa Prolactin and Bromocriptine in Postpartum Cardiomyopathy

Update Kardiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.