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Erschienen in:

05.01.2021 | Editorial

Mechanical dyssynchrony and super-response to CRT

verfasst von: K. A. Jones, MSc, N. E. R. Goodfield, MBChB, MRCP

Erschienen in: Journal of Nuclear Cardiology | Ausgabe 3/2022

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Excerpt

Cardiac resynchronisation therapy (CRT) is a well-established and important treatment option for patients in heart failure, which improves survival, morbidity, and quality of life.13 However, CRT is not an effective treatment for all patients and despite all the research that the selection criteria is based on,4 approximately 30% of patients who undergo CRT therapy are classified as non-responders.5 CRT is costly and not without risk; therefore, finding ways to predict responders to CRT is of clinical interest. …
Literatur
1.
Zurück zum Zitat Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: The MIRACLE ICD Trial. JAMA 2003;289:2685-94.CrossRef Young JB, Abraham WT, Smith AL, Leon AR, Lieberman R, Wilkoff B, et al. Combined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: The MIRACLE ICD Trial. JAMA 2003;289:2685-94.CrossRef
2.
Zurück zum Zitat Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005;352:1539-49.CrossRef Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. N Engl J Med 2005;352:1539-49.CrossRef
3.
Zurück zum Zitat Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:2140-50.CrossRef Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 2004;350:2140-50.CrossRef
4.
Zurück zum Zitat Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129-200.CrossRef Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J 2016;37:2129-200.CrossRef
5.
Zurück zum Zitat Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, et al. Results of the predictors of response to CRT (PROSPECT) trial. ECHO. 2008;2608:2616. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, et al. Results of the predictors of response to CRT (PROSPECT) trial. ECHO. 2008;2608:2616.
6.
Zurück zum Zitat Thavendiranathan P, Grant AD, Negishi T, Plana JC, Popović ZB, Marwick TH. Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: Application to patients undergoing cancer chemotherapy. J Am Coll Cardiol 2013;61:77-84.CrossRef Thavendiranathan P, Grant AD, Negishi T, Plana JC, Popović ZB, Marwick TH. Reproducibility of echocardiographic techniques for sequential assessment of left ventricular ejection fraction and volumes: Application to patients undergoing cancer chemotherapy. J Am Coll Cardiol 2013;61:77-84.CrossRef
7.
Zurück zum Zitat Hawkins NM, Petrie MC, MacDonald MR, Hogg KJ, McMurray JJ. Selecting patients for cardiac resynchronization therapy: Electrical or mechanical dyssynchrony? Eur Heart J 2006;27:1270-81.CrossRef Hawkins NM, Petrie MC, MacDonald MR, Hogg KJ, McMurray JJ. Selecting patients for cardiac resynchronization therapy: Electrical or mechanical dyssynchrony? Eur Heart J 2006;27:1270-81.CrossRef
8.
Zurück zum Zitat Stankovic I, Prinz C, Ciarka A, Daraban AM, Kotrc M, Aarones M, et al. Relationship of visually assessed apical rocking and septal flash to response and long-term survival following cardiac resynchronization therapy (PREDICT-CRT). Eur Heart J Cardiovasc Imaging 2016;17:262-9.CrossRef Stankovic I, Prinz C, Ciarka A, Daraban AM, Kotrc M, Aarones M, et al. Relationship of visually assessed apical rocking and septal flash to response and long-term survival following cardiac resynchronization therapy (PREDICT-CRT). Eur Heart J Cardiovasc Imaging 2016;17:262-9.CrossRef
9.
Zurück zum Zitat Gorcsan J, Anderson CP, Tayal B, Sugahara M, Walmsley J, Starling RC, et al. Systolic stretch characterizes the electromechanical substrate responsive to cardiac resynchronization therapy. JACC 2019;12:1741-52.PubMed Gorcsan J, Anderson CP, Tayal B, Sugahara M, Walmsley J, Starling RC, et al. Systolic stretch characterizes the electromechanical substrate responsive to cardiac resynchronization therapy. JACC 2019;12:1741-52.PubMed
10.
Zurück zum Zitat Aalen JM, Donal E, Larsen CK, Duchenne J, Lederlin M, Cvijic M, et al. Imaging predictors of response to cardiac resynchronization therapy: Left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance. Eur Heart J 2020;41:3813-23.CrossRef Aalen JM, Donal E, Larsen CK, Duchenne J, Lederlin M, Cvijic M, et al. Imaging predictors of response to cardiac resynchronization therapy: Left ventricular work asymmetry by echocardiography and septal viability by cardiac magnetic resonance. Eur Heart J 2020;41:3813-23.CrossRef
11.
Zurück zum Zitat Menet A, Bernard A, Tribouilloy C, Leclercq C, Gevaert C, Guyomar Y, et al. Clinical significance of septal deformation patterns in heart failure patients receiving cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging 2017;18:1388-97.CrossRef Menet A, Bernard A, Tribouilloy C, Leclercq C, Gevaert C, Guyomar Y, et al. Clinical significance of septal deformation patterns in heart failure patients receiving cardiac resynchronization therapy. Eur Heart J Cardiovasc Imaging 2017;18:1388-97.CrossRef
12.
Zurück zum Zitat Mukherjee A, Patel CD, Naik N, Sharma G, Roy A. Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with non-ischaemic dilated cardiomyopathy using equilibrium radionuclide angiography. Europace 2016;18:851-7.CrossRef Mukherjee A, Patel CD, Naik N, Sharma G, Roy A. Quantitative assessment of cardiac mechanical dyssynchrony and prediction of response to cardiac resynchronization therapy in patients with non-ischaemic dilated cardiomyopathy using equilibrium radionuclide angiography. Europace 2016;18:851-7.CrossRef
13.
Zurück zum Zitat Badhwar N, James J, Hoffmayer KS, O’Connell JW, Green D, De Marco T, et al. Utility of equilibrium radionuclide angiogram–derived measures of dyssynchrony to predict outcomes in heart failure patients undergoing cardiac resynchronization therapy. J Nucl Med 2016;57:1880-6.CrossRef Badhwar N, James J, Hoffmayer KS, O’Connell JW, Green D, De Marco T, et al. Utility of equilibrium radionuclide angiogram–derived measures of dyssynchrony to predict outcomes in heart failure patients undergoing cardiac resynchronization therapy. J Nucl Med 2016;57:1880-6.CrossRef
14.
Zurück zum Zitat Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL, et al. Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 2005;12:687-95.CrossRef Chen J, Garcia EV, Folks RD, Cooke CD, Faber TL, Tauxe EL, et al. Onset of left ventricular mechanical contraction as determined by phase analysis of ECG-gated myocardial perfusion SPECT imaging: Development of a diagnostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 2005;12:687-95.CrossRef
15.
Zurück zum Zitat Peix A, Karthikeyan G, Massardo T, Kalaivani M, Patel C, Pabon LM, et al. Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT). J Nucl Cardiol 2019;24:1-10. Peix A, Karthikeyan G, Massardo T, Kalaivani M, Patel C, Pabon LM, et al. Value of intraventricular dyssynchrony assessment by gated-SPECT myocardial perfusion imaging in the management of heart failure patients undergoing cardiac resynchronization therapy (VISION-CRT). J Nucl Cardiol 2019;24:1-10.
16.
Zurück zum Zitat Blanc JJ, Fatemi M, Bertault V, Baraket F, Etienne Y. Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure: A new concept of left ventricular dyssynchrony-induced cardiomyopathy. EP Eur. 2005;7:604-10.CrossRef Blanc JJ, Fatemi M, Bertault V, Baraket F, Etienne Y. Evaluation of left bundle branch block as a reversible cause of non-ischaemic dilated cardiomyopathy with severe heart failure: A new concept of left ventricular dyssynchrony-induced cardiomyopathy. EP Eur. 2005;7:604-10.CrossRef
17.
Zurück zum Zitat Hsu JC, Solomon SD, Bourgoun M, McNitt S, Goldenberg I, Klein H, et al. MADIT-CRT Executive Committee. Predictors of super-response to cardiac resynchronization therapy and associated improvement in clinical outcome: The MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy) study. J Am Coll Cardiol 2012;59:2366-73.CrossRef Hsu JC, Solomon SD, Bourgoun M, McNitt S, Goldenberg I, Klein H, et al. MADIT-CRT Executive Committee. Predictors of super-response to cardiac resynchronization therapy and associated improvement in clinical outcome: The MADIT-CRT (multicenter automatic defibrillator implantation trial with cardiac resynchronization therapy) study. J Am Coll Cardiol 2012;59:2366-73.CrossRef
19.
Zurück zum Zitat Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, et al. Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med 2007;48:1104-11.CrossRef Henneman MM, Chen J, Dibbets-Schneider P, Stokkel MP, Bleeker GB, Ypenburg C, et al. Can LV dyssynchrony as assessed with phase analysis on gated myocardial perfusion SPECT predict response to CRT? J Nucl Med 2007;48:1104-11.CrossRef
20.
Zurück zum Zitat Reant P, Zaroui A, Donal E, Mignot A, Bordachar P, Deplagne A, Solnon A, Ritter P, Daubert JC, Clementy J, Leclercq C. Identification and characterization of super-responders after cardiac resynchronization therapy. J Am Coll Cardiol 2010;105:1327-35.CrossRef Reant P, Zaroui A, Donal E, Mignot A, Bordachar P, Deplagne A, Solnon A, Ritter P, Daubert JC, Clementy J, Leclercq C. Identification and characterization of super-responders after cardiac resynchronization therapy. J Am Coll Cardiol 2010;105:1327-35.CrossRef
Metadaten
Titel
Mechanical dyssynchrony and super-response to CRT
verfasst von
K. A. Jones, MSc
N. E. R. Goodfield, MBChB, MRCP
Publikationsdatum
05.01.2021
Verlag
Springer International Publishing
Erschienen in
Journal of Nuclear Cardiology / Ausgabe 3/2022
Print ISSN: 1071-3581
Elektronische ISSN: 1532-6551
DOI
https://doi.org/10.1007/s12350-020-02453-1

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