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Inflammation
Erschienen in: Inflammation 5/2018

28.06.2018 | REVIEW

Mechanisms of Hemolysis During Sepsis

verfasst von: Katharina Effenberger-Neidnicht, Matthias Hartmann

Erschienen in: Inflammation | Ausgabe 5/2018

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Abstract

Cell-free hemoglobin is increasingly playing a more central role in the pathogenesis of sepsis being proved to be a potent predictor of patient’s outcome. It is crucial, hence, to further investigate the mechanisms of sepsis-induced hemolysis with the aim of deriving possible therapeutic principles. Herein, we collected the most important previously known triggers of hemolysis during sepsis, which are (1) transfusion reactions and complement activation, (2) disseminated intravascular coagulation, (3) capillary stopped-flow, (4) restriction of glucose to red blood cells, (5) changes in red blood cell membrane properties, (6) hemolytic pathogens, and (7) red blood cell apoptosis.
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Metadaten
Titel
Mechanisms of Hemolysis During Sepsis
verfasst von
Katharina Effenberger-Neidnicht
Matthias Hartmann
Publikationsdatum
28.06.2018
Verlag
Springer US
Erschienen in
Inflammation / Ausgabe 5/2018
Print ISSN: 0360-3997
Elektronische ISSN: 1573-2576
DOI
https://doi.org/10.1007/s10753-018-0810-y

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