nach oben

Arthritis Research & Therapy

Erschienen in:

01.04.2010 | Review

Gout. Mechanisms of inflammation in gout

verfasst von: Nathalie Busso, Alexander So

Erschienen in: Arthritis Research & Therapy | Ausgabe 2/2010

Einloggen, um Zugang zu erhalten

Abstract

An acute attack of gout is a paradigm of acute sterile inflammation, as opposed to pyogenic inflammation. Recent studies suggest that the triggering of IL-1β release from leucocytes lies at the heart of a cascade of processes that involves multiple cytokines and mediators. The NLRP3 inflammasome appears to have a specific role in this regard, but the biochemical events leading to its activation are still not well understood. We review the known mechanisms that underlie the inflammatory process triggered by urate crystals and suggest areas that require further research.

Nur mit Berechtigung zugänglich

McCarty DJ, Hollander JL: Identification of urate crystals in gouty synovial fluid. Ann Intern Med. 1961, 54: 452-460.CrossRefPubMed

Kippen I, Klinenberg JR, Weinberger A, Wilcox WR: Factors affecting urate solubility in vitro. Ann Rheum Dis. 1974, 33: 313-317. 10.1136/ard.33.4.313.PubMedCentralCrossRefPubMed

Katz WA, Schubert M: The interaction of monosodium urate with connective tissue components. J Clin Invest. 1970, 49: 1783-1789. 10.1172/JCI106396.PubMedCentralCrossRefPubMed

Nakamura Y, Kambe N, Saito M, Nishikomori R, Kim YG, Murakami M, Nunez G, Matsue H: Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria. J Exp Med. 2009, 206: 1037-1046. 10.1084/jem.20082179.PubMedCentralCrossRefPubMed

Ginsberg MH, Kozin F: Mechanisms of cellular interaction with monosodium urate crystals. IgG-dependent and IgG-independent platelet stimulation by urate crystals. Arthritis Rheum. 1978, 21: 896-903. 10.1002/art.1780210805.CrossRefPubMed

Ortiz-Bravo E, Sieck MS, Schumacher HR: Changes in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model. Arthritis Rheum. 1993, 36: 1274-1285. 10.1002/art.1780360912.CrossRefPubMed

Landis RC, Yagnik DR, Florey O, Philippidis P, Emons V, Mason JC, Haskard DO: Safe disposal of inflammatory monosodium urate monohydrate crystals by differentiated macrophages. Arthritis Rheum. 2002, 46: 3026-3033. 10.1002/art.10614.CrossRefPubMed

Hoffstein S, Weissmann G: Mechanisms of lysosomal enzyme release from leukocytes. IV. Interaction of monosodium urate crystals with dogfish and human leukocytes. Arthritis Rheum. 1975, 18: 153-165. 10.1002/art.1780180213.CrossRefPubMed

Kozin F, Ginsberg MH, Skosey JL: Polymorphonuclear leukocyte responses to monosodium urate crystals: modification by adsorbed serum proteins. J Rheumatol. 1979, 6: 519-526.PubMed

10.

Nuki G: Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Curr Rheumatol Rep. 2008, 10: 218-227. 10.1007/s11926-008-0036-3.CrossRefPubMed

11.

Torres R, Macdonald L, Croll SD, Reinhardt J, Dore A, Stevens S, Hylton DM, Rudge JS, Liu-Bryan R, Terkeltaub RA, Yancopoulos GD, Murphy AJ: Hyperalgesia, synovitis, and multiple biomarkers of inflammation are suppressed by IL-1 inhibition in a novel animal model of gouty arthritis. Ann Rheum Dis. 2009, 68: 1602-1608. 10.1136/ard.2009.109355.CrossRefPubMed

12.

Di Giovine FS, Malawista SE, Nuki G, Duff GW: Interleukin 1 (IL 1) as a mediator of crystal arthritis. Stimulation of T cell and synovial fibroblast mitogenesis by urate crystal-induced IL 1. J Immunol. 1987, 138: 3213-3218.PubMed

13.

di Giovine FS, Malawista SE, Thornton E, Duff GW: Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells. Cytokine mRNA and protein kinetics, and cellular distribution. J Clin Invest. 1991, 87: 1375-1381. 10.1172/JCI115142.PubMedCentralCrossRefPubMed

14.

Yagnik DR, Evans BJ, Florey O, Mason JC, Landis RC, Haskard DO: Macrophage release of transforming growth factor beta1 during resolution of monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 2004, 50: 2273-2280. 10.1002/art.20317.CrossRefPubMed

15.

Martin WJ, Walton M, Harper J: Resident macrophages initiating and driving inflammation in a monosodium urate monohydrate crystal-induced murine peritoneal model of acute gout. Arthritis Rheum. 2009, 60: 281-289. 10.1002/art.24185.CrossRefPubMed

16.

Schiltz C, Liote F, Prudhommeaux F, Meunier A, Champy R, Callebert J, Bardin T: Monosodium urate monohydrate crystal-induced inflammation in vivo: quantitative histomorphometric analysis of cellular events. Arthritis Rheum. 2002, 46: 1643-1650. 10.1002/art.10326.CrossRefPubMed

17.

Pessler F, Mayer CT, Jung SM, Behrens EM, Dai L, Menetski JP, Schumacher HR: Identification of novel monosodium urate crystal regulated mRNAs by transcript profiling of dissected murine air pouch membranes. Arthritis Res Ther. 2008, 10: R64-10.1186/ar2435.PubMedCentralCrossRefPubMed

18.

Getting SJ, Flower RJ, Parente L, de Medicis R, Lussier A, Woliztky BA, Martins MA, Perretti M: Molecular determinants of monosodium urate crystal-induced murine peritonitis: a role for endogenous mast cells and a distinct requirement for endothelial-derived selectins. J Pharmacol Exp Ther. 1997, 283: 123-130.PubMed

19.

Chen CJ, Shi Y, Hearn A, Fitzgerald K, Golenbock D, Reed G, Akira S, Rock KL: MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest. 2006, 116: 2262-2271. 10.1172/JCI28075.PubMedCentralCrossRefPubMed

20.

So A, De Smedt T, Revaz S, Tschopp J: A pilot study of IL-1 inhibition by anakinra in acute gout. Arthritis Res Ther. 2007, 9: R28-10.1186/ar2143.PubMedCentralCrossRefPubMed

21.

So A, De Meulemeester M, Pikhlak A, Yücel E, Richard D, Murphy V, Arulmani U, Sallstig P, Schlesinger N: Canakinumab (ACZ885) vs. triamcinolone acetonide for treatment of acute flares and prevention of recurrent flares in gouty arthritis patients refractory to or contraindicated to NSAIDs and/or colchicine [abstract LB4]. ACR Annual Meeting 2009. 2009, Philadelphia: Wiley

22.

Schumacher HR, Sundy J, Terkeltaub R, Knapp HR, Mellis S, Soo Y, King-Davis S, Weinstein S, Radin A: Placebo-controlled study of rilonacept for gout flare prophylaxis during intiation of urate-lowering therapy [abstract 1096]. ACR Annual Meeting 2009. 2009, Philadelphia: Wiley

23.

Dinarello CA: Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol. 2009, 27: 519-550. 10.1146/annurev.immunol.021908.132612.CrossRefPubMed

24.

Martinon F, Mayor A, Tschopp J: The inflammasomes: guardians of the body. Annu Rev Immunol. 2009, 27: 229-265. 10.1146/annurev.immunol.021908.132715.CrossRefPubMed

25.

Guma M, Ronacher L, Liu-Bryan R, Takai S, Karin M, Corr M: Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum. 2009, 60: 3642-3650. 10.1002/art.24959.PubMedCentralCrossRefPubMed

26.

Joosten LA, Netea MG, Fantuzzi G, Koenders MI, Helsen MM, Sparrer H, Pham CT, Meer van der JW, Dinarello CA, Berg van den WB: Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1β. Arthritis Rheum. 2009, 60: 3651-3662. 10.1002/art.25006.PubMedCentralCrossRefPubMed

27.

Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J: Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006, 440: 237-241. 10.1038/nature04516.CrossRefPubMed

28.

Dostert C, Petrilli V, Van Bruggen R, Steele C, Mossman BT, Tschopp J: Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 2008, 320: 674-677. 10.1126/science.1156995.PubMedCentralCrossRefPubMed

29.

Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS, Flavell RA: Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature. 2008, 453: 1122-1126. 10.1038/nature06939.CrossRefPubMed

30.

Dostert C, Guarda G, Romero JF, Menu P, Gross O, Tardivel A, Suva ML, Stehle JC, Kopf M, Stamenkovic I, Corradin G, Tschopp J: Malarial hemozoin is a Nalp3 inflammasome activating danger signal. PLoS ONE. 2009, 4: e6510-10.1371/journal.pone.0006510.PubMedCentralCrossRefPubMed

31.

Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross PJ, Parks RJ, Tschopp J: The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature. 2008, 452: 103-107. 10.1038/nature06664.CrossRefPubMed

32.

Santos Moreno P, Latore C: Treatment of severe gouty arthritis with etanercept [abstract]. Ann Rheum Dis. 2009, 68 (Suppl 3): 680-

33.

Tausche AK, Richter K, Grassler A, Hansel S, Roch B, Schroder HE: Severe gouty arthritis refractory to anti-inflammatory drugs: treatment with anti-tumour necrosis factor alpha as a new therapeutic option. Ann Rheum Dis. 2004, 63: 1351-1352. 10.1136/ard.2003.015743.PubMedCentralCrossRefPubMed

34.

Fiehn C, Zeier M: Successful treatment of chronic tophaceous gout with infliximab (Remicade). Rheumatol Int. 2006, 26: 274-276. 10.1007/s00296-005-0617-7.CrossRefPubMed

35.

Terkeltaub R, Baird S, Sears P, Santiago R, Boisvert W: The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis. Arthritis Rheum. 1998, 41: 900-909. 10.1002/1529-0131(199805)41:5<900::AID-ART18>3.0.CO;2-K.CrossRefPubMed

36.

Nishimura A, Akahoshi T, Takahashi M, Takagishi K, Itoman M, Kondo H, Takahashi Y, Yokoi K, Mukaida N, Matsushima K: Attenuation of monosodium urate crystal-induced arthritis in rabbits by a neutralizing antibody against interleukin-8. J Leukoc Biol. 1997, 62: 444-449.PubMed

37.

Hachicha M, Naccache PH, McColl SR: Inflammatory microcrystals differentially regulate the secretion of macrophage inflammatory protein 1 and interleukin 8 by human neutrophils: a possible mechanism of neutrophil recruitment to sites of inflammation in synovitis. J Exp Med. 1995, 182: 2019-2025. 10.1084/jem.182.6.2019.CrossRefPubMed

38.

Akira S, Takeda K: Toll-like receptor signalling. Nat Rev Immunol. 2004, 4: 499-511. 10.1038/nri1391.CrossRefPubMed

39.

Beutler B: Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases. Immunol Rev. 2009, 227: 248-263. 10.1111/j.1600-065X.2008.00733.x.PubMedCentralCrossRefPubMed

40.

Liu-Bryan R, Scott P, Sydlaske A, Rose DM, Terkeltaub R: Innate immunity conferred by Toll-like receptors 2 and 4 and myeloid differentiation factor 88 expression is pivotal to monosodium urate monohydrate crystal-induced inflammation. Arthritis Rheum. 2005, 52: 2936-2946. 10.1002/art.21238.CrossRefPubMed

41.

Scott P, Ma H, Viriyakosol S, Terkeltaub R, Liu-Bryan R: Engagement of CD14 mediates the inflammatory potential of monosodium urate crystals. J Immunol. 2006, 177: 6370-6378.CrossRefPubMed

42.

Ford JW, McVicar DW: TREM and TREM-like receptors in inflammation and disease. Curr Opin Immunol. 2009, 21: 38-46. 10.1016/j.coi.2009.01.009.PubMedCentralCrossRefPubMed

43.

Murakami Y, Akahoshi T, Hayashi I, Endo H, Kawai S, Inoue M, Kondo H, Kitasato H: Induction of triggering receptor expressed on myeloid cells 1 in murine resident peritoneal macrophages by monosodium urate monohydrate crystals. Arthritis Rheum. 2006, 54: 455-462. 10.1002/art.21633.CrossRefPubMed

44.

Giclas PC, Ginsberg MH, Cooper NR: Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals. J Clin Invest. 1979, 63: 759-764. 10.1172/JCI109360.PubMedCentralCrossRefPubMed

45.

Russell IJ, Papaioannou C, McDuffie FC, MacIntyre S, Kushner I: Effect of IgG and C-reactive protein on complement depletion by monosodium urate crystals. J Rheumatol. 1983, 10: 425-433.PubMed

46.

Fields TR, Abramson SB, Weissmann G, Kaplan AP, Ghebrehiwet B: Activation of the alternative pathway of complement by monosodium urate crystals. Clin Immunol Immunopathol. 1983, 26: 249-257. 10.1016/0090-1229(83)90143-5.CrossRefPubMed

47.

Russell IJ, Mansen C, Kolb LM, Kolb WP: Activation of the fifth component of human complement (C5) induced by monosodium urate crystals: C5 convertase assembly on the crystal surface. Clin Immunol Immunopathol. 1982, 24: 239-250. 10.1016/0090-1229(82)90235-5.CrossRefPubMed

48.

Serhan CN, Lundberg U, Weissmann G, Samuelsson B: Formation of leukotrienes and hydroxy acids by human neutrophils and platelets exposed to monosodium urate. Prostaglandins. 1984, 27: 563-581. 10.1016/0090-6980(84)90092-3.CrossRefPubMed

49.

Rae SA, Davidson EM, Smith MJ: Leukotriene B4, an inflammatory mediator in gout. Lancet. 1982, 2: 1122-1124. 10.1016/S0140-6736(82)92785-4.CrossRefPubMed

50.

Forrest MJ, Zammit V, Brooks PM: Inhibition of leucotriene B4 synthesis by BW 755c does not reduce polymorphonuclear leucocyte (PMNL) accumulation induced by monosodium urate crystals. Ann Rheum Dis. 1988, 47: 241-246. 10.1136/ard.47.3.241.PubMedCentralCrossRefPubMed

Titel: Gout. Mechanisms of inflammation in gout
verfasst von: Nathalie Busso
Alexander So
Publikationsdatum: 01.04.2010
Verlag: BioMed Central
Erschienen in: Arthritis Research & Therapy / Ausgabe 2/2010
Elektronische ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2952

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

24.04.2024 | DGIM 2024 | Kongressbericht | Nachrichten

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Gout. Mechanisms of inflammation in gout

Abstract

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2010

Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor

The loss of health status in rheumatoid arthritis and the effect of biologic therapy: a longitudinal observational study

Development of proteoglycan-induced arthritis depends on T cell-supported autoantibody production, but does not involve significant influx of T cells into the joints

Automated evaluation of autoantibodies on human epithelial-2 cells as an approach to standardize cell-based immunofluorescence tests

Interferon-γ inhibits interleukin-1β-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis

Myofiber stress-response in myositis: parallel investigations on patients and experimental animal models of muscle regeneration and systemic inflammation

Leitlinien kompakt für die Innere Medizin

Neu im Fachgebiet Innere Medizin

Metformin rückt in den Hintergrund

Myokarditis nach Infekt – richtig schwierig wird es bei Profisportlern

Thrombophiliescreening – Wenn, dann richtig und nur bei therapeutischer Konsequenz

Bei Senioren mit Prostatakarzinom auf Anämie achten!

Update Innere Medizin