Skip to main content
main-content

28.08.2018 | Bone and Joint Pain (T King and S Amin, Section Editors) | Ausgabe 5/2018 Open Access

Current Osteoporosis Reports 5/2018

Mechanisms of Osteoarthritis (OA) Pain

Zeitschrift:
Current Osteoporosis Reports > Ausgabe 5/2018
Autoren:
Terence W. O’Neill, David T. Felson
Wichtige Hinweise
This article is part of the Topical Collection on Bone and Joint Pain

Abstract

Purpose of Review

Osteoarthritis (OA) is a major cause of pain and disability worldwide. There is, however, a relatively poor correlation between the severity of OA based on plain radiograph changes and symptoms. In this review, we consider the mechanisms of pain in OA.

Recent Findings

It is now widely recognised that OA is a disease of the whole joint. Data from large observational studies which have used magnetic resonance imaging (MRI) suggest that pain in OA is associated with a number of structural factors including the presence of bone marrow lesions (BMLs) and also synovitis. There is evidence also of alterations in nerve processing and that both peripheral and central nerve sensitisation may contribute to pain in OA.

Summary

Identification of the causes of pain in an individual patient may be of benefit in helping to better target with appropriate therapy to help reduce their symptoms and improve function.

Unsere Produktempfehlungen

e.Med Interdisziplinär

Kombi-Abonnement

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Bis zum 22.10. bestellen und 100 € sparen!

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 5/2018

Current Osteoporosis Reports 5/2018 Zur Ausgabe

Regenerative Biology and Medicine in Osteoporosis (T Webster, Section Editor)

Carbon Nanomaterials for Treating Osteoporotic Vertebral Fractures

Cancer-induced Musculoskeletal Diseases (J Sterling and E Keller, Section Editors)

Interactions Between Disseminated Tumor Cells and Bone Marrow Stromal Cells Regulate Tumor Dormancy

Epidemiology and Pathophysiology (F Cosman and D Shoback, Section Editors)

The Influence of Cortical Porosity on the Strength of Bone During Growth and Advancing Age

Epidemiology and Pathophysiology (F Cosman and D Shoback, Section Editors)

The Effects of Homocysteine on the Skeleton

Neu im Fachgebiet Orthopädie und Unfallchirurgie

 

 

 
 

Mail Icon II Newsletter

Bestellen Sie unseren kostenlosen Newsletter Update Orthopädie und Unfallchirurgie und bleiben Sie gut informiert – ganz bequem per eMail.

Bildnachweise