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Erschienen in: Wiener klinisches Magazin 3/2016

31.05.2016 | Schwerpunkt ERA-EDTA

Mediators of necroinflammation in kidney disease

verfasst von: M.D. Hans-Joachim Anders

Erschienen in: Wiener klinisches Magazin | Ausgabe 3/2016

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Excerpt

Known since ancient times: tissue injury and inflammation often go together but what are the underlying molecular mechanisms? Inflammation triggers cell death via complement activation or cytotoxic T cells. Dying cells release molecules that trigger inflammation by activating pattern recognition receptors (PRR) of the innate immune system. This bidirectional relationship between inflammation and cell necrosis fuelling an autoamplification loop is referred to as necroinflammation (Fig. 1; [5]). Necroinflammation is accelerated by immunity-related cell necrosis and cell necrosis-related immune activation. Necroinflammation can be initiated by a few necrotic cells that activate the innate immune system, which subsequently leads to necrosis of more cells triggering more inflammation, a process that can eventually lead to organ failure (Fig. 1).
Literatur
1.
Zurück zum Zitat Mulay SR, Linkermann A, Anders HJ (2016) Necroinflammation in kidney disease. J Am Soc Nephrol 27(1):27–39CrossRefPubMed Mulay SR, Linkermann A, Anders HJ (2016) Necroinflammation in kidney disease. J Am Soc Nephrol 27(1):27–39CrossRefPubMed
2.
Zurück zum Zitat Mulay SR, Desai J, Kumar S, Eberhardt JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ (2016) Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Nat Commun 7:10274CrossRefPubMedPubMedCentral Mulay SR, Desai J, Kumar S, Eberhardt JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ (2016) Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis. Nat Commun 7:10274CrossRefPubMedPubMedCentral
3.
Zurück zum Zitat Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, Vilaysane A, Muruve D, Shi Y, Munro F, Liapis H, Anders HJ. (2013) Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion. J Clin Invest. 2013 Jan;123(1):236–46. Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, Vilaysane A, Muruve D, Shi Y, Munro F, Liapis H, Anders HJ. (2013) Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion. J Clin Invest. 2013 Jan;123(1):236–46.
4.
Zurück zum Zitat Kumar SV, Kulkarni OP, Mulay SR, Darisipudi MN, Romoli S, Thomasova D, Scherbaum CR, Hohenstein B, Hugo C, Müller S, Liapis H, Anders HJ (2015) Neutrophil extracellular trap-related extracellular histones cause vascular necrosis in severe GN. J Am Soc Nephrol 26:2399–2413CrossRefPubMed Kumar SV, Kulkarni OP, Mulay SR, Darisipudi MN, Romoli S, Thomasova D, Scherbaum CR, Hohenstein B, Hugo C, Müller S, Liapis H, Anders HJ (2015) Neutrophil extracellular trap-related extracellular histones cause vascular necrosis in severe GN. J Am Soc Nephrol 26:2399–2413CrossRefPubMed
5.
Zurück zum Zitat Linkermann A, Stockwell BR, Krautwald S, Anders HJ (2014) Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nat Rev Immunol 14(11):759–767CrossRefPubMed Linkermann A, Stockwell BR, Krautwald S, Anders HJ (2014) Regulated cell death and inflammation: an auto-amplification loop causes organ failure. Nat Rev Immunol 14(11):759–767CrossRefPubMed
Metadaten
Titel
Mediators of necroinflammation in kidney disease
verfasst von
M.D. Hans-Joachim Anders
Publikationsdatum
31.05.2016
Verlag
Springer Vienna
Erschienen in
Wiener klinisches Magazin / Ausgabe 3/2016
Print ISSN: 1869-1757
Elektronische ISSN: 1613-7817
DOI
https://doi.org/10.1007/s00740-016-0114-5

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