Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar: Aktuelle Leitlinien bei Herz-Kreislauf-Erkrankungen

Konkret geht es um den Diabetes-Patienten mit kardiovaskulären Erkrankungen oder Risiken, die Herzinsuffizienz sowie die kardiovaskuläre Primär- und Sekundärprävention. Sind Sie hier schon auf dem neuesten Stand? Unsere Experten beleuchten, wo und warum das bisherige Procedere geändert werden soll und was in der Praxis sinnvoll ist. Holen Sie sich Ihr Update und 2 CME-Punkte beim MMW-Webinar am 24. April von 17.30 bis 19 Uhr. 
Erweiterte Suche
Anmelden
nach oben
Current Neurology and Neuroscience Reports
Erschienen in: Current Neurology and Neuroscience Reports 7/2016

01.07.2016 | Sleep (M Thorpy and M Billiard Section Editors)

Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases

verfasst von: Lynn Marie Trotti, Elias G. Karroum

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 7/2016

Einloggen, um Zugang zu erhalten

Abstract

In patients with neurodegenerative diseases, sleep disorders are common; they impair the quality of life for patients and caregivers and are associated with poorer clinical outcomes. Melatonin has circadian, hypnotic, and free radical-scavenging effects, and preclinical data suggest benefits of melatonin on neurodegeneration. However, randomized, controlled trials of melatonin in patients with neurodegenerative diseases have not shown strong effects. Trials in Alzheimer’s patients demonstrate a lack of benefit on sleep quantity. Subjective measures of sleep quality are mixed, with possible symptomatic improvements seen only on some measures or at some time points. Benefits on cognition have not been observed across several studies. In Parkinson’s patients, there may be minimal benefit on objective sleep measures, but a suggestion of subjective benefit in few, small studies. Effective treatments for the sleep disorders associated with neurodegenerative diseases are urgently needed, but current data are insufficient to establish melatonin as such a treatment.
Literatur
1.
2.
Raggi A, Ferri R. Sleep disorders in neurodegenerative diseases. Eur J Neurol. 2010;17:1326–38.PubMed
3.
Hauw JJ, Hausser-Hauw C, De Girolami U, et al. Neuropathology of sleep disorders: a review. J Neuropathol Exp Neurol. 2011;70:243–52.CrossRefPubMed
4.
Naismith SL, Lewis SJ, Rogers NL. Sleep-wake changes and cognition in neurodegenerative disease. Prog Brain Res. 2011;190:21–52.CrossRefPubMed
5.
Zhong G, Naismith SL, Rogers NL, et al. Sleep-wake disturbances in common neurodegenerative diseases: a closer look at selected aspects of the neural circuitry. J Neurol Sci. 2011;307:9–14.CrossRefPubMed
6.
Dauvilliers Y. Insomnia in patients with neurodegenerative conditions. Sleep Med. 2007;8 Suppl 4:S27–34.CrossRefPubMed
7.
8.
Bonanni E, Maestri M, Tognoni G, et al. Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res. 2005;14:311–7.CrossRefPubMed
9.
10.
Bachman D, Rabins P. "Sundowning" and other temporally associated agitation states in dementia patients. Annu Rev Med. 2006;57:499–511.CrossRefPubMed
11.
Gaig C, Iranzo A. Sleep-disordered breathing in neurodegenerative diseases. Curr Neurol Neurosci Rep. 2012;12:205–17.CrossRefPubMed
12.
Iranzo A, Comella CL, Santamaria J, et al. Restless legs syndrome in Parkinson’s disease and other neurodegenerative diseases of the central nervous system. Mov Disord. 2007;22 Suppl 18:S424–30.CrossRefPubMed
13.
Bliwise DL, Trotti LM, Yesavage JA, et al. Periodic leg movements in sleep in elderly patients with Parkinsonism and Alzheimer’s disease. Eur J Neurol. 2012;19:918–23.CrossRefPubMedPubMedCentral
14.
Howell MJ, Schenck CH. Rapid eye movement sleep behavior disorder and neurodegenerative disease. JAMA Neurol. 2015;72:707–12.CrossRefPubMed
15.
Claustrat B, Brun J, Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Med Rev. 2005;9:11–24.CrossRefPubMed
16.
Pevet P, Challet E. Melatonin: both master clock output and internal time-giver in the circadian clocks network. J Physiol Paris. 2011;105:170–82.CrossRefPubMed
17.
Manchester LC, Coto-Montes A, Boga JA, et al. Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res. 2015;59:403–19.CrossRefPubMed
18.•
Pandi-Perumal SR, BaHammam AS, Brown GM, et al. Melatonin antioxidative defense: therapeutical implications for aging and neurodegenerative processes. Neurotox Res. 2013;23:267–300. Comprehensive review of melatonin’s anti-oxidant properties and potential utility in neurodegenerative diseases. CrossRefPubMed
19.
Jenwitheesuk A, Nopparat C, Mukda S, et al. Melatonin regulates aging and neurodegeneration through energy metabolism, epigenetics, autophagy and circadian rhythm pathways. Int J Mol Sci. 2014;15:16848–84.CrossRefPubMedPubMedCentral
20.
Kuriyama A, Honda M, Hayashino Y. Ramelteon for the treatment of insomnia in adults: a systematic review and meta-analysis. Sleep Med. 2014;15:385–92.CrossRefPubMed
21.
Lockley SW, Dressman MA, Licamele L, et al. Tasimelteon for non-24-hour sleep-wake disorder in totally blind people (set and reset): two multicentre, randomised, double-masked, placebo-controlled phase 3 trials. Lancet. 2015;386:1754–64.CrossRefPubMed
22.
Alberti S, Chiesa A, Andrisano C, et al. Insomnia and somnolence associated with second-generation antidepressants during the treatment of major depression: a meta-analysis. J Clin Psychopharmacol. 2015;35:296–303.CrossRefPubMed
23.
Corruble E, de Bodinat C, Belaidi C, et al. Efficacy of agomelatine and escitalopram on depression, subjective sleep and emotional experiences in patients with major depressive disorder: a 24-wk randomized, controlled, double-blind trial. Int J Neuropsychopharmacol. 2013;16:2219–34.CrossRefPubMed
24.
Review manager (revman). 5.3 ed. Copenhagen: The Nordic Cochrane Centre: The Cochrane Collaboration; 2014.
25.
Benca RM, Obermeyer WH, Thisted RA, et al. Sleep and psychiatric-disorders—a meta-analysis. Arch Gen Psychiatry. 1992;49:651–68.CrossRefPubMed
26.
Moran M, Lynch CA, Walsh C, et al. Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med. 2005;6:347–52.CrossRefPubMed
27.
Guarnieri B, Adorni F, Musicco M, et al. Prevalence of sleep disturbances in mild cognitive impairment and dementing disorders: a multicenter Italian clinical cross-sectional study on 431 patients. Dement Geriatr Cogn Disord. 2012;33:50–8.CrossRefPubMedPubMedCentral
28.
Zhao QF, Tan L, Wang HF, et al. The prevalence of neuropsychiatric symptoms in Alzheimer’s disease: systematic review and meta-analysis. J Affect Disord. 2016;190:264–71.CrossRefPubMed
29.
Hatfield CF, Herbert J, van Someren EJW, et al. Disrupted daily activity/rest cycles in relation to daily cortisol rhythms of home-dwelling patients with early Alzheimer’s dementia. Brain. 2004;127:1061–74.CrossRefPubMed
30.
International classification of sleep disorders. 3rd ed. Darien, IL: American Academy of Sleep Medicine; 2014.
31.
Cardinali DP, Furio AM, Brusco LI. The use of chronobiotics in the resynchronization of the sleep/wake cycle. Therapeutical application in the early phases of Alzheimer’s disease. Recent Patents Endocr Metab Immune Drug Discov. 2011;5:80–90.CrossRef
32.•
Peter-Derex L, Yammine P, Bastuji H, et al. Sleep and Alzheimer’s disease. Sleep Med Rev. 2015;19:29–38. A well-written review of the bidirectional relationships between sleep and AD. CrossRefPubMed
33.
Yin Y, Liu Y, Zhuang J, et al. Low-dose atypical antipsychotic risperidone improves the 5-year outcome in Alzheimer’s disease patients with sleep disturbances. Pharmacology. 2015;96:155–62.CrossRefPubMed
34.
Bianchetti A, Scuratti A, Zanetti O, et al. Predictors of mortality and institutionalization in Alzheimer disease patients 1 year after-discharge from an Alzheimer dementia unit. Dementia. 1995;6:108–12.PubMed
35.
You SC, Walsh CM, Chiodo LA, et al. Neuropsychiatric symptoms predict functional status in Alzheimer’s disease. J Alzheimers Dis. 2015;48:863–9.CrossRefPubMedPubMedCentral
36.
Shin HY, Han HJ, Shin DJ, et al. Sleep problems associated with behavioral and psychological symptoms as well as cognitive functions in Alzheimer’s disease. J Clin Neurol. 2014;10:203–9.CrossRefPubMedPubMedCentral
37.
Spalletta G, Long JD, Robinson RG, et al. Longitudinal neuropsychiatric predictors of death in Alzheimer’s disease. J Alzheimers Dis. 2015;48:627–36.CrossRefPubMed
38.
Liu RY, Zhou JN, van Heerikhuize J, et al. Decreased melatonin levels in postmortem cerebrospinal fluid in relation to aging, Alzheimer's disease, and apolipoprotein e-epsilon4/4 genotype. J Clin Endocrinol Metab. 1999;84:323–7.PubMed
39.
Duffy JF, Zitting KM, Chinoy ED. Aging and circadian rhythms. Sleep Med Clin. 2015;10:423–34.CrossRefPubMed
40.
Mishima K, Tozawa T, Satoh K, et al. Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer's type with disturbed sleep-waking. Biol Psychiatry. 1999;45:417–21.CrossRefPubMed
41.
Zhou JN, Liu RY, Kamphorst W, et al. Early neuropathological Alzheimer's changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res. 2003;35:125–30.CrossRefPubMed
42.
Musiek ES, Xiong DD, Holtzman DM. Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease. Exp Mol Med. 2015;47.
43.
Mahlberg R, Walther S, Kalus P, et al. Pineal calcification in Alzheimer's disease: an in vivo study using computed tomography. Neurobiol Aging. 2008;29:203–9.CrossRefPubMed
44.
Wu YH, Swaab DF. Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer's disease. Sleep Med. 2007;8:623–36.CrossRefPubMed
45.•
Scullin MK, Bliwise DL. Sleep, cognition, and normal aging: integrating a half century of multidisciplinary research. Perspect Psychol Sci. 2015;10:97–137. Extensive synthesis of relationship between sleep and cognition in young and older adults. CrossRefPubMedPubMedCentral
46.
Villa C, Ferini-Strambi L, Combi R. The synergistic relationship between Alzheimer's disease and sleep disorders: An update. J Alzheimers Dis. 2015;46:571–80.CrossRefPubMed
47.
Bedrosian TA, Herring KL, Weil ZM, et al. Altered temporal patterns of anxiety in aged and amyloid precursor protein (app) transgenic mice. Proc Natl Acad Sci U S A. 2011;108:11686–91.CrossRefPubMedPubMedCentral
48.
Pappolla MA, Sos M, Omar RA, et al. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J Neurosci. 1997;17:1683–90.PubMed
49.
Bozner P, Grishko V, LeDoux SP, et al. The amyloid beta protein induces oxidative damage of mitochondrial DNA. J Neuropathol Exp Neurol. 1997;56:1356–62.CrossRefPubMed
50.
Pappolla M, Bozner P, Soto C, et al. Inhibition of Alzheimer beta-fibrillogenesis by melatonin. J Biol Chem. 1998;273:7185–8.CrossRefPubMed
51.
Poeggeler B, Miravalle L, Zagorski MG, et al. Melatonin reverses the profibrillogenic activity of apolipoprotein e4 on the Alzheimer amyloid Abeta peptide. Biochemistry. 2001;40:14995–5001.CrossRefPubMed
52.
Matsubara E, Bryant-Thomas T, Pacheco Quinto J, et al. Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease. J Neurochem. 2003;85:1101–8.CrossRefPubMed
53.
Feng Z, Qin C, Chang Y, et al. Early melatonin supplementation alleviates oxidative stress in a transgenic mouse model of Alzheimer's disease. Free Radic Biol Med. 2006;40:101–9.CrossRefPubMed
54.
Olcese JM, Cao C, Mori T, et al. Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res. 2009;47:82–96.CrossRefPubMed
55.
Dragicevic N, Copes N, O'Neal-Moffitt G, et al. Melatonin treatment restores mitochondrial function in Alzheimer's mice: a mitochondrial protective role of melatonin membrane receptor signaling. J Pineal Res. 2011;51:75–86.CrossRefPubMed
56.
Garcia-Mesa Y, Gimenez-Llort L, Lopez LC, et al. Melatonin plus physical exercise are highly neuroprotective in the 3xtg-ad mouse. Neurobiol Aging. 2012;33(1124):e13–29.PubMed
57.
Rudnitskaya EA, Muraleva NA, Maksimova KY, et al. Melatonin attenuates memory impairment, amyloid-beta accumulation, and neurodegeneration in a rat model of sporadic Alzheimer's disease. J Alzheimers Dis. 2015;47:103–16.CrossRefPubMed
58.
O'Neal-Moffitt G, Delic V, Bradshaw PC, et al. Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in abetapp(swe)/ps1 mice. Mol Neurodegener. 2015;10:27.CrossRefPubMedPubMedCentral
59.
Rosales-Corral S, Tan DX, Reiter RJ, et al. Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E. J Pineal Res. 2003;35:80–4.CrossRefPubMed
60.
Yang X, Yang Y, Fu Z, et al. Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A. J Psychopharmacol. 2011;25:1118–25.CrossRefPubMed
61.••
Singer C, Tractenberg RE, Kaye J, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003;26:893–901. A randomized controlled trial of melatonin in neurodegenerative disease. PubMedPubMedCentral
62.••
Dowling GA, Burr RL, Van Someren EJ, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc. 2008;56:239–46. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRefPubMed
63.••
Gehrman PR, Connor DJ, Martin JL, et al. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatr Off J Am Assoc Geriatr Psychiatr. 2009;17:166–9. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRef
64.••
Asayama K, Yamadera H, Ito T, et al. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch = Nippon Ika Daigaku zasshi. 2003;70:334–41. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRefPubMed
65.••
Wade AG, Farmer M, Harari G, et al. Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer's disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging. 2014;9:947–61. A randomized controlled trial of melatonin in neurodegenerative disease. PubMedPubMedCentral
66.••
Serfaty M, Kennell-Webb S, Warner J, et al. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatr. 2002;17:1120–7. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRef
67.••
Haffmans PM, Sival RC, Lucius SA, et al. Bright light therapy and melatonin in motor restless behaviour in dementia: a placebo-controlled study. Int J Geriatr Psychiatr. 2001;16:106–10. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRef
68.••
Riemersma-van der Lek RF, Swaab DF, Twisk J, et al. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008;299:2642–55. A randomized controlled trial of melatonin in neurodegenerative disease.
69.
Auger RR, Burgess HJ, Emens JS, et al. Clinical practice guideline for the treatment of intrinsic circadian rhythm sleep-wake disorders: advanced sleep-wake phase disorder (aswpd), delayed sleep-wake phase disorder (dswpd), non-24-hour sleep-wake rhythm disorder (n24swd), and irregular sleep-wake rhythm disorder (iswrd). An update for 2015: an american academy of sleep medicine clinical practice guideline. J Clin Sleep Med. 2015;11:1199–236.CrossRefPubMedPubMedCentral
70.
Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosurg Psychiatry. 2008;79:368–76.CrossRefPubMed
71.
Barone P, Antonini A, Colosimo C, et al. The priamo study: A multicenter assessment of nonmotor symptoms and their impact on quality of life in Parkinson’s disease. Mov Disord. 2009;24:1641–9.CrossRefPubMed
72.
Suzuki K, Miyamoto M, Miyamoto T, et al. Parkinson’s disease and sleep/wake disturbances. Curr Neurol Neurosci Rep. 2015;15:8.CrossRefPubMed
73.
Bliwise DL, Trotti LM, Rye DB. Movement disorders specific to sleep and the nocturnal manifestations of waking movement disorders. In: Watts RL, Standaert DG, Obeso J, editors. Movement disorders. 3rd ed: McGraw-Hill; 2011. p. 935-74.
74.
75.
Ratti PL, Negre-Pages L, Perez-Lloret S, et al. Subjective sleep dysfunction and insomnia symptoms in Parkinson’s disease: insights from a cross-sectional evaluation of the French copark cohort. Parkinsonism Relat Disord. 2015;21:1323–9.CrossRefPubMed
76.
Wang P, Wing YK, Xing J, et al. Rapid eye movement sleep behavior disorder in patients with probable alzheimer's disease. Aging Clin Exp Res. 2015.
77.
Boeve BF. REM sleep behavior disorder: updated review of the core features, the REM sleep behavior disorder-neurodegenerative disease association, evolving concepts, controversies, and future directions. Ann N Y Acad Sci. 2010;1184:15–54.CrossRefPubMedPubMedCentral
78.
Karlsen KH, Larsen JP, Tandberg E, et al. Influence of clinical and demographic variables on quality of life in patients with Parkinson’s disease. J Neurol Neurosurg Psychiatry. 1999;66:431–5.CrossRefPubMedPubMedCentral
79.
Forsaa EB, Larsen JP, Wentzel-Larsen T, et al. Predictors and course of health-related quality of life in Parkinson’s disease. Mov Disord. 2008;23:1420–7.CrossRefPubMed
80.
Bolitho SJ, Naismith SL, Rajaratnam SM, et al. Disturbances in melatonin secretion and circadian sleep-wake regulation in Parkinson disease. Sleep Med. 2014;15:342–7.CrossRefPubMed
81.
Fertl E, Auff E, Doppelbauer A, et al. Circadian secretion pattern of melatonin in de novo parkinsonian patients: evidence for phase-shifting properties of l-dopa. J Neural Transm Parkinsons Dis Dement Sect. 1993;5:227–34.CrossRef
82.
Videnovic A, Breen DP, Barker RA, et al. The central clock in patients with parkinson disease—reply. JAMA Neurol. 2014;71:1456–7.CrossRefPubMed
83.
Videnovic A, Noble C, Reid KJ, et al. Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol. 2014;71:463–9.CrossRefPubMedPubMedCentral
84.
Mayo JC, Sainz RM, Tan DX, et al. Melatonin and Parkinson’s disease. Endocrine. 2005;27:169–78.CrossRefPubMed
85.
Belaid H, Adrien J, Karachi C, et al. Effect of melatonin on sleep disorders in a monkey model of Parkinson’s disease. Sleep Med. 2015;16:1245–51.CrossRefPubMed
86.
Gutierrez-Valdez AL, Anaya-Martinez V, Ordonez-Librado JL, et al. Effect of chronic l-dopa or melatonin treatments after dopamine deafferentation in rats: dyskinesia, motor performance, and cytological analysis. ISRN Neurol. 2012;2012:360379.CrossRefPubMedPubMedCentral
87.
Zaitone SA, Hammad LN, Farag NE. Antioxidant potential of melatonin enhances the response to l-dopa in 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine-parkinsonian mice. Pharmacol Rep. 2013;65:1213–26.CrossRefPubMed
88.
Naskar A, Manivasagam T, Chakraborty J, et al. Melatonin synergizes with low doses of l-dopa to improve dendritic spine density in the mouse striatum in experimental Parkinsonism. J Pineal Res. 2013;55:304–12.CrossRefPubMed
89.
Patki G, Lau YS. Melatonin protects against neurobehavioral and mitochondrial deficits in a chronic mouse model of Parkinson’s disease. Pharmacol Biochem Behav. 2011;99:704–11.CrossRefPubMedPubMedCentral
90.
Yildirim FB, Ozsoy O, Tanriover G, et al. Mechanism of the beneficial effect of melatonin in experimental Parkinson’s disease. Neurochem Int. 2014;79:1–11.CrossRefPubMed
91.
Bassani TB, Gradowski RW, Zaminelli T, et al. Neuroprotective and antidepressant-like effects of melatonin in a rotenone-induced Parkinson’s disease model in rats. Brain Res. 2014;1593:95–105.CrossRefPubMed
92.
Carriere CH, Kang NH, Niles LP. Chronic low-dose melatonin treatment maintains nigrostriatal integrity in an intrastriatal rotenone model of Parkinson’s disease. Brain Res 2015.
93.
Willis GL, Armstrong SM. A therapeutic role for melatonin antagonism in experimental models of parkinson’s disease. Physiol Behav. 1999;66:785–95.CrossRefPubMed
94.
Tapias V, Cannon JR, Greenamyre JT. Melatonin treatment potentiates neurodegeneration in a rat rotenone parkinson’s disease model. J Neurosci Res. 2010;88:420–7.CrossRefPubMed
95.••
Dowling GA, Mastick J, Colling E, et al. Melatonin for sleep disturbances in Parkinson’s disease. Sleep Med. 2005;6:459–66. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRefPubMed
96.••
Medeiros CA, de Carvalhedo Bruin PF, Lopes LA, et al. Effect of exogenous melatonin on sleep and motor dysfunction in parkinson's disease. A randomized, double blind, placebo-controlled study. J Neurol. 2007;254:459–64. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRefPubMed
97.
Seppi K, Weintraub D, Coelho M, et al. The movement disorder society evidence-based medicine review update: treatments for the non-motor symptoms of Parkinson’s disease. Mov Disord. 2011;26 Suppl 3:S42–80.CrossRefPubMedPubMedCentral
98.••
Kunz D, Mahlberg R. A two-part, double-blind, placebo-controlled trial of exogenous melatonin in REM sleep behaviour disorder. J Sleep Res. 2010;19:591–6. A randomized controlled trial of melatonin in neurodegenerative disease. CrossRefPubMed
99.
Boeve BF, Silber MH, Ferman TJ. Melatonin for treatment of REM sleep behavior disorder in neurologic disorders: results in 14 patients. Sleep Med. 2003;4:281–4.CrossRefPubMed
100.
Lauterbach EC, Victoroff J, Coburn KL, et al. Psychopharmacological neuroprotection in neurodegenerative disease: assessing the preclinical data. J Neuropsychiatr Clin Neurosci. 2010;22:8–18.CrossRef
101.
Schutte-Rodin S, Broch L, Buysse D, et al. Clinical guideline for the evaluation and management of chronic insomnia in adults. J Clin Sleep Med. 2008;4:487–504.PubMedPubMedCentral
102.
Wu YH, Zhou JN, Van Heerikhuize J, et al. Decreased mt1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer’s disease. Neurobiol Aging. 2007;28:1239–47.CrossRefPubMed
103.
Obayashi K, Saeki K, Iwamoto J, et al. Physiological levels of melatonin relate to cognitive function and depressive symptoms: The heijo-kyo cohort. J Clin Endocrinol Metab. 2015;100:3090–6.CrossRefPubMed
104.
Avila A, Cardona X, Martin-Baranera M, et al. Agomelatine for depression in Parkinson disease: additional effect on sleep and motor dysfunction. J Clin Psychopharmacol. 2015;35:719–23.CrossRefPubMed
105.
Hatta K, Kishi Y, Wada K, et al. Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial. JAMA Psychiatr. 2014;71:397–403.CrossRef
Metadaten
Titel
Melatonin for Sleep Disorders in Patients with Neurodegenerative Diseases
verfasst von
Lynn Marie Trotti
Elias G. Karroum
Publikationsdatum
01.07.2016
Verlag
Springer US
Erschienen in
Current Neurology and Neuroscience Reports / Ausgabe 7/2016
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI
https://doi.org/10.1007/s11910-016-0664-3

Weitere Artikel der Ausgabe 7/2016

Current Neurology and Neuroscience Reports 7/2016 Zur Ausgabe

Demyelinating Disorders (DN Bourdette and M Cameron, Section Editors)

Paediatric Multiple Sclerosis: Update on Diagnostic Criteria, Imaging, Histopathology and Treatment Choices

Nerve and Muscle (LH Weimer, Section Editor)

Facioscapulohumeral Dystrophy

Neurology of Systemic Diseases (J Biller, Section Editor)

Neurological Complications of Pregnancy

Epilepsy (CW Bazil, Section Editor)

New Techniques and Progress in Epilepsy Surgery

Neuroimaging (DJ Brooks, Section Editor)

Migraine: What Imaging Reveals

Infection (J Halperin, Section Editor)

Neurologic Complications in Treated HIV-1 Infection

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Kostenlos registrieren

Neu im Fachgebiet Neurologie

18.04.2024 | Arterielle Hypertonie | Nachrichten

Antihypertensiva schützen auch alte Menschen noch vor Demenz

18.04.2024 | Spinale Muskelatrophien | Nachrichten

Spinale Muskelatrophie: Neugeborenen-Screening lohnt sich

16.04.2024 | Maligne primäre ZNS-Tumoren | Nachrichten

Manche Gestagene können das Risiko für Meningeome erhöhen

15.04.2024 | Parkinson-Krankheit | Nachrichten

Parkinson: Größere Studie bestätigt Genauigkeit von Hauttest
weitere anzeigen

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen
Bildnachweise